Fast HPLC Method for the Determination of Piroxicam and its Application to Stability Study

Panainte, Alina Diana; Vieriu, Madalina; Tantaru, Gladiola; Apostu, Mihai; Bibire, Nela

Alina Diana Panainte, Madalina Vieriu, Gladiola Tantaru, Mihai Apostu, Nela Bibire

Fast HPLC Method for the Determination of Piroxicam and its Application to Stability Study

Abstract:

A fast and robust RP-HPLC isocratic method was developed for determination of piroxicam in bulk materials and pharmaceutical formulations. Optimum separation of piroxicam and stress induced degradation a product was achieved using a SB-C18 Eclipse column (150x4.6; 5µm). The mobile phase was a mixture of water: acetonitrile (50:50) with a flow rate of 0.5mL/min. The UV detection was performed at 360nm. The method was validated in accordance with the current ICH guidelines in terms of linearity, limit of detection, limit of quantification, precision, accuracy, recovery and system suitability. The retention time for piroxicam was 2.55 min. The calibration graph was linear in the concentration range 5-90µg/mL. The assay proved to be sensitive, specific and reproducible. The method was applied for the determination of piroxicam in tablets.

Keywords:
piroxicam; pharmaceutical formulations; HPLC; UV

Issue: 2017, Volume 68, Issue 4

Pages: 701-706

Publication date: 2017/5/15

https://doi.org/10.37358/RC.17.4.5534

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This article is published under the Creative Commons Attribution 4.0 International License

Citation Styles

Cite this article as:
PANAINTE, A.D., VIERIU, M., TANTARU, G., APOSTU, M., BIBIRE, N., Fast HPLC Method for the Determination of Piroxicam and its Application to Stability Study, Rev. Chim., 68(4), 2017, 701-706.

Vancouver
Panainte AD, Vieriu M, Tantaru G, Apostu M, Bibire N. Fast HPLC Method for the Determination of Piroxicam and its Application to Stability Study. Rev. Chim.[internet]. 2017 Apr;68(4):701-706. Available from: https://doi.org/10.37358/RC.17.4.5534

APA 6th edition
Panainte, A.D., Vieriu, M., Tantaru, G., Apostu, M. & Bibire, N. (2017). Fast HPLC Method for the Determination of Piroxicam and its Application to Stability Study. Revista de Chimie, 68(4), 701-706. https://doi.org/10.37358/RC.17.4.5534

Harvard
Panainte, A.D., Vieriu, M., Tantaru, G., Apostu, M., Bibire, N. (2017). 'Fast HPLC Method for the Determination of Piroxicam and its Application to Stability Study', Revista de Chimie, 68(4), pp. 701-706. https://doi.org/10.37358/RC.17.4.5534

IEEE
A.D. Panainte, M. Vieriu, G. Tantaru, M. Apostu, N. Bibire, "Fast HPLC Method for the Determination of Piroxicam and its Application to Stability Study". Revista de Chimie, vol. 68, no. 4, pp. 701-706, 2017. [online]. https://doi.org/10.37358/RC.17.4.5534

Text
Alina Diana Panainte, Madalina Vieriu, Gladiola Tantaru, Mihai Apostu, Nela Bibire,
Fast HPLC Method for the Determination of Piroxicam and its Application to Stability Study,
Revista de Chimie,
Volume 68, Issue 4,
2017,
Pages 701-706,
ISSN 2668-8212,
https://doi.org/10.37358/RC.17.4.5534.
(https://revistadechimie.ro/Articles.asp?ID=5534)
Keywords: piroxicam; pharmaceutical formulations; HPLC; UV

RIS
TY - JOUR
T1 - Fast HPLC Method for the Determination of Piroxicam and its Application to Stability Study
A1 - Panainte, Alina Diana
A2 - Vieriu, Madalina
A3 - Tantaru, Gladiola
A4 - Apostu, Mihai
A5 - Bibire, Nela
JF - Revista de Chimie
JO - Rev. Chim.
PB - Revista de Chimie SRL
SN - 2668-8212
Y1 - 2017
VL - 68
IS - 4
SP - 701
EP - 706
UR - https://doi.org/10.37358/RC.17.4.5534
KW - piroxicam
KW - pharmaceutical formulations
KW - HPLC
KW - UV
ER -

BibTex
@article{RevCh2017P701,
author = {Panainte Alina Diana and Vieriu Madalina and Tantaru Gladiola and Apostu Mihai and Bibire Nela},
title = {Fast HPLC Method for the Determination of Piroxicam and its Application to Stability Study},
journal = {Revista de Chimie},
volume = {68},
number = {4},
pages = {701-706},
year = {2017},
issn = {2668-8212},
doi = {https://doi.org/10.37358/RC.17.4.5534},
url = {https://revistadechimie.ro/Articles.asp?ID=5534}
}

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