ALINA DIANA PANAINTE, MADALINA VIERIU, GLADIOLA TANTARU, MIHAI APOSTU, NELA BIBIRE FAST HPLC METHOD FOR THE DETERMINATION OF PIROXICAM AND ITS APPLICATION TO STABILITY STUDY A fast and robust RP-HPLC isocratic method was developed for determination of piroxicam in bulk materials and pharmaceutical formulations. Optimum separation of piroxicam and stress induced degradation a product was achieved using a SB-C18 Eclipse column (150x4.6; 5µm). The mobile phase was a mixture of water: acetonitrile (50:50) with a flow rate of 0.5mL/min. The UV detection was performed at 360nm. The method was validated in accordance with the current ICH guidelines in terms of linearity, limit of detection, limit of quantification, precision, accuracy, recovery and system suitability. The retention time for piroxicam was 2.55 min. The calibration graph was linear in the concentration range 5-90µg/mL. The assay proved to be sensitive, specific and reproducible. The method was applied for the determination of piroxicam in tablets.