Multivariate Statistical Analysis Regarding the Formulation of Oxicam-Based Pharmaceutical Hydrogels

Suta, Lenuta Maria; Tudor, Anca; Sandulovici, Colette Roxana; Stelea, Lavinia; Hadaruga, Daniel; Mircioiu, Constantin; Balint, Germaine Savoiu

Lenuta Maria Suta, Anca Tudor, Colette Roxana Sandulovici, Lavinia Stelea, Daniel Hadaruga, Constantin Mircioiu, Germaine Savoiu Balint

Multivariate Statistical Analysis Regarding the Formulation of Oxicam-Based Pharmaceutical Hydrogels

Abstract:

In this paper, it was analysed the influence of formulation factors over obtaining oxicam hydrogels, using the statistical analysis. Data analysis and predictive modeling by multivariate regression offers a large number of possible explanatory/predictive variables. Therefore, variable selection and dimension reduction is a major task for multivariate statistical analysis, especially for multivariate regressions. The statistical analysis and computational data processing of responses obtained from different pharmaceutical formulations, via different experimental protocols, lead to the optimization of the formulation process. It was found that the most suitable pharmaceutical formulations based on oxicams with the possibility of rapid release contained cyclodextrin, in particular 2-hydroxypropyl-b-cyclodextrin.

Keywords:
oxicam; pharmaceutical formulation; hydrogel; cyclodextrin; multivariate statistical analysis

Issue: 2017, Volume 68, Issue 4

Pages: 726-731

Publication date: 2017/5/15

https://doi.org/10.37358/RC.17.4.5539

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This article is published under the Creative Commons Attribution 4.0 International License

Citation Styles

Cite this article as:
SUTA, L.M., TUDOR, A., SANDULOVICI, C.R., STELEA, L., HADARUGA, D., MIRCIOIU, C., BALINT, G.S., Multivariate Statistical Analysis Regarding the Formulation of Oxicam-Based Pharmaceutical Hydrogels, Rev. Chim., 68(4), 2017, 726-731.

Vancouver
Suta LM, Tudor A, Sandulovici CR, Stelea L, Hadaruga D, Mircioiu C, Balint GS. Multivariate Statistical Analysis Regarding the Formulation of Oxicam-Based Pharmaceutical Hydrogels. Rev. Chim.[internet]. 2017 Apr;68(4):726-731. Available from: https://doi.org/10.37358/RC.17.4.5539

APA 6th edition
Suta, L.M., Tudor, A., Sandulovici, C.R., Stelea, L., Hadaruga, D., Mircioiu, C. & Balint, G.S. (2017). Multivariate Statistical Analysis Regarding the Formulation of Oxicam-Based Pharmaceutical Hydrogels. Revista de Chimie, 68(4), 726-731. https://doi.org/10.37358/RC.17.4.5539

Harvard
Suta, L.M., Tudor, A., Sandulovici, C.R., Stelea, L., Hadaruga, D., Mircioiu, C., Balint, G.S. (2017). 'Multivariate Statistical Analysis Regarding the Formulation of Oxicam-Based Pharmaceutical Hydrogels', Revista de Chimie, 68(4), pp. 726-731. https://doi.org/10.37358/RC.17.4.5539

IEEE
L.M. Suta, A. Tudor, C.R. Sandulovici, L. Stelea, D. Hadaruga, C. Mircioiu, G.S. Balint, "Multivariate Statistical Analysis Regarding the Formulation of Oxicam-Based Pharmaceutical Hydrogels". Revista de Chimie, vol. 68, no. 4, pp. 726-731, 2017. [online]. https://doi.org/10.37358/RC.17.4.5539

Text
Lenuta Maria Suta, Anca Tudor, Colette Roxana Sandulovici, Lavinia Stelea, Daniel Hadaruga, Constantin Mircioiu, Germaine Savoiu Balint,
Multivariate Statistical Analysis Regarding the Formulation of Oxicam-Based Pharmaceutical Hydrogels,
Revista de Chimie,
Volume 68, Issue 4,
2017,
Pages 726-731,
ISSN 2668-8212,
https://doi.org/10.37358/RC.17.4.5539.
(https://revistadechimie.ro/Articles.asp?ID=5539)
Keywords: oxicam; pharmaceutical formulation; hydrogel; cyclodextrin; multivariate statistical analysis

RIS
TY - JOUR
T1 - Multivariate Statistical Analysis Regarding the Formulation of Oxicam-Based Pharmaceutical Hydrogels
A1 - Suta, Lenuta Maria
A2 - Tudor, Anca
A3 - Sandulovici, Colette Roxana
A4 - Stelea, Lavinia
A5 - Hadaruga, Daniel
A6 - Mircioiu, Constantin
A7 - Balint, Germaine Savoiu
JF - Revista de Chimie
JO - Rev. Chim.
PB - Revista de Chimie SRL
SN - 2668-8212
Y1 - 2017
VL - 68
IS - 4
SP - 726
EP - 731
UR - https://doi.org/10.37358/RC.17.4.5539
KW - oxicam
KW - pharmaceutical formulation
KW - hydrogel
KW - cyclodextrin
KW - multivariate statistical analysis
ER -

BibTex
@article{RevCh2017P726,
author = {Suta Lenuta Maria and Tudor Anca and Sandulovici Colette Roxana and Stelea Lavinia and Hadaruga Daniel and Mircioiu Constantin and Balint Germaine Savoiu},
title = {Multivariate Statistical Analysis Regarding the Formulation of Oxicam-Based Pharmaceutical Hydrogels},
journal = {Revista de Chimie},
volume = {68},
number = {4},
pages = {726-731},
year = {2017},
issn = {2668-8212},
doi = {https://doi.org/10.37358/RC.17.4.5539},
url = {https://revistadechimie.ro/Articles.asp?ID=5539}
}

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