GEORGE MIHAI NITULESCU, GEORGE IANCU, GEORGIANA NITULESCU, RALUCA CLAUDIA IANCU, CAMELIA BOGDANICI, DANUT VASILE BRAVE NEW HOPE FOR BREAST CANCER AMINOPYRAZOLE DERIVATES BETWEEN RATIONAL DESIGN AND CLINICAL EFFICACY Breast cancer research is a priority nowadays because of the high burden the disease represents for health systems worldwide. New agents are intensively researched to overcome breast cancer biology. Our aminopyrazole derivatives showed promising results when tested in vitro on breast cancer cell lines, by inhibiting protein kinase pathways. Anti-proliferative effect of pyrazole compounds on different breast cancer cell lines was heterogeneous. Further research is necessary to design the optimal structure in terms of high antitumor efficacy and good safety profile. Ophthalmologist control is very important for patients with breast cancer because treatment with some drugs reported side ocular effects: cataract, maculopathy (crystals or drusen or yellowish spots), retinal hemorrhages or dry.
Keywords: aminopyrazole derivatives, Prediction of Activity Spectra for Substances (PASS), triple-negative breast cancer, protein kinases inhibitors