LAURA ANCA POPESCU, BOGDANA VIRGOLICI, DACIANA COSTINA ANDRADA STEFAN, DANIELA LIXANDRU, OLIVIA TIMNEA, HORIA VIRGOLICI, DUMITRU ORASEANU, CRINA SINESCU, MARIA MOHORA VASCULAR REACTIVITY AND PROINFLAMMATORY CYTOKINES IN THE OBESE CHILDREN The aim of this study was to evaluate the relation between inflammatory markers and the preatherosclerotic marker - flow mediated dilation (FMD). Thirty obese children (10-16 years old) and twenty controls were involved. The plasma inflammatory markers: CRP, fibrinogen, leptin, TNF-a, IL-6 were measured. Ultrasounds were used for FMD measurement, chemiluminescence for monocyte respiratory burst (RB), ELISA for C peptide and spectrophotometry for usual parameters. In the obese children versus the lean ones, the FMD was lower (p<0.001), the plasma values for TNF-a were similar (1.68 pg/mL vs 1.54 pg/mL), while plasma IL-6 was increased (4.01 pg/mL vs. 2.02 pg/mL, p<0.05). These cytokines were negatively correlated with FMD (r=-0.42, p<0.05) and positively with RB (r=50, p<0.05). The FMD was negatively correlated (p<0.05) with the values for diastolic blood pressure (r = -0.47), waist circumference (r = -0.55), uric acid (r = -0.47) and atherosclerotic index (r = -0.37). In conclusion, in the obese children, inflammation, dyslipidaemia, blood pressure and oxidative stress act in a cluster reducing the elasticity of the vessel walls.