The Involvement of Epicardial Adiposity and Inflammation in Postoperatory Atrial Fibrilation - Immunohistochemical Qualitative and Quantitative Assessment

Butcovan, Doina; Oboroceanu, Teodor; Cimpeanu, Ciprian; Mironescu, Aurel; Haliga, Raluca Ecaterina; Pinzariu, Alin Constantin; Lupusoru, Raoul Vasile; Popescu, Eugenia; Mocanu, Veronica

Doina Butcovan, Teodor Oboroceanu, Ciprian Cimpeanu, Aurel Mironescu, Raluca Ecaterina Haliga, Alin Constantin Pinzariu, Raoul Vasile Lupusoru, Eugenia Popescu, Veronica Mocanu

The Involvement of Epicardial Adiposity and Inflammation in Postoperatory Atrial Fibrilation - Immunohistochemical Qualitative and Quantitative Assessment

Abstract:

Postoperatory atrial fibrillation (AF) is a common complication after cardiac surgery. Among others cardiac structural changes, epicardial adiposity (EA) and inflammation could be associated with increased cardiovascular risk, including AF. Because there are not enough studies on the association between epicardial fat and inflammation in AF, this paper assesses the association between structural changes in human right atrial appendages (RAA) in patients with and without AF with focus on EA and inflammation. RAA specimens from 20 coronary patients (ages 60 ± 10 years) were divided in 2 groups including patients with and without postoperatory AF. Histological, immunohistochemical (IMH) and morphometrical methods were used for assessing EA, myocardial fatty infiltration, epicardial inflammatory foci, cardiomyocytes size and vacuolation and extent of interstitial fibrosis. Atrial changes were found in most patients from both groups, having higher proportions in postoperatory AF patients. EA extent and myocardial fatty infiltration were twofold to threefold higher in patients with postoperatory AF and associated epicardial mononuclear inflammation. RAA structural changes can indicate the susceptibility to develop postoperatory AF. Currently, EA and inflammation have recently emerged as new independent AF risk factors. So, we proposed to study RAA structural changes, including EA, epicardial inflammatory foci in relation with postoperatory AF frequency.

Keywords:
epicardial inflammation; epicardial adiposity; atrial fibrillation; atrial fibrosis; cardiac surgery

Issue: 2017, Volume 68, Issue 4

Pages: 886-889

Publication date: 2017/5/15

https://doi.org/10.37358/RC.17.4.5571

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This article is published under the Creative Commons Attribution 4.0 International License

Citation Styles

Cite this article as:
BUTCOVAN, D., OBOROCEANU, T., CIMPEANU, C., MIRONESCU, A., HALIGA, R.E., PINZARIU, A.C., LUPUSORU, R.V., POPESCU, E., MOCANU, V., The Involvement of Epicardial Adiposity and Inflammation in Postoperatory Atrial Fibrilation - Immunohistochemical Qualitative and Quantitative Assessment, Rev. Chim., 68(4), 2017, 886-889.

Vancouver
Butcovan D, Oboroceanu T, Cimpeanu C, Mironescu A, Haliga RE, Pinzariu AC, Lupusoru RV, Popescu E, Mocanu V. The Involvement of Epicardial Adiposity and Inflammation in Postoperatory Atrial Fibrilation - Immunohistochemical Qualitative and Quantitative Assessment. Rev. Chim.[internet]. 2017 Apr;68(4):886-889. Available from: https://doi.org/10.37358/RC.17.4.5571

APA 6th edition
Butcovan, D., Oboroceanu, T., Cimpeanu, C., Mironescu, A., Haliga, R.E., Pinzariu, A.C.,... Mocanu, V. (2017). The Involvement of Epicardial Adiposity and Inflammation in Postoperatory Atrial Fibrilation - Immunohistochemical Qualitative and Quantitative Assessment. Revista de Chimie, 68(4), 886-889. https://doi.org/10.37358/RC.17.4.5571

Harvard
Butcovan, D., Oboroceanu, T., Cimpeanu, C., Mironescu, A., Haliga, R.E., Pinzariu, A.C., Lupusoru, R.V., Popescu, E., Mocanu, V. (2017). 'The Involvement of Epicardial Adiposity and Inflammation in Postoperatory Atrial Fibrilation - Immunohistochemical Qualitative and Quantitative Assessment', Revista de Chimie, 68(4), pp. 886-889. https://doi.org/10.37358/RC.17.4.5571

IEEE
D. Butcovan, T. Oboroceanu, C. Cimpeanu, A. Mironescu, R.E. Haliga, A.C. Pinzariu, R.V. Lupusoru, E. Popescu, V. Mocanu, "The Involvement of Epicardial Adiposity and Inflammation in Postoperatory Atrial Fibrilation - Immunohistochemical Qualitative and Quantitative Assessment". Revista de Chimie, vol. 68, no. 4, pp. 886-889, 2017. [online]. https://doi.org/10.37358/RC.17.4.5571

Text
Doina Butcovan, Teodor Oboroceanu, Ciprian Cimpeanu, Aurel Mironescu, Raluca Ecaterina Haliga, Alin Constantin Pinzariu, Raoul Vasile Lupusoru, Eugenia Popescu, Veronica Mocanu,
The Involvement of Epicardial Adiposity and Inflammation in Postoperatory Atrial Fibrilation - Immunohistochemical Qualitative and Quantitative Assessment,
Revista de Chimie,
Volume 68, Issue 4,
2017,
Pages 886-889,
ISSN 2668-8212,
https://doi.org/10.37358/RC.17.4.5571.
(https://revistadechimie.ro/Articles.asp?ID=5571)
Keywords: epicardial inflammation; epicardial adiposity; atrial fibrillation; atrial fibrosis; cardiac surgery

RIS
TY - JOUR
T1 - The Involvement of Epicardial Adiposity and Inflammation in Postoperatory Atrial Fibrilation - Immunohistochemical Qualitative and Quantitative Assessment
A1 - Butcovan, Doina
A2 - Oboroceanu, Teodor
A3 - Cimpeanu, Ciprian
A4 - Mironescu, Aurel
A5 - Haliga, Raluca Ecaterina
A6 - Pinzariu, Alin Constantin
A7 - Lupusoru, Raoul Vasile
A8 - Popescu, Eugenia
A9 - Mocanu, Veronica
JF - Revista de Chimie
JO - Rev. Chim.
PB - Revista de Chimie SRL
SN - 2668-8212
Y1 - 2017
VL - 68
IS - 4
SP - 886
EP - 889
UR - https://doi.org/10.37358/RC.17.4.5571
KW - epicardial inflammation
KW - epicardial adiposity
KW - atrial fibrillation
KW - atrial fibrosis
KW - cardiac surgery
ER -

BibTex
@article{RevCh2017P886,
author = {Butcovan Doina and Oboroceanu Teodor and Cimpeanu Ciprian and Mironescu Aurel and Haliga Raluca Ecaterina and Pinzariu Alin Constantin and Lupusoru Raoul Vasile and Popescu Eugenia and Mocanu Veronica},
title = {The Involvement of Epicardial Adiposity and Inflammation in Postoperatory Atrial Fibrilation - Immunohistochemical Qualitative and Quantitative Assessment},
journal = {Revista de Chimie},
volume = {68},
number = {4},
pages = {886-889},
year = {2017},
issn = {2668-8212},
doi = {https://doi.org/10.37358/RC.17.4.5571},
url = {https://revistadechimie.ro/Articles.asp?ID=5571}
}

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