Optimization of Gold Nanoparticles Synthesis using Design of Experiments Technique

Stiolica, Adina Turcu; Popescu, Mariana; Bubulica, Maria Viorica; Oancea, Carmen Nicoleta; Nicolicescu, Claudiu; Manda, Costel Valentin; Neamtu, Johny; Croitoru, Octavian

Adina Turcu Stiolica, Mariana Popescu, Maria Viorica Bubulica, Carmen Nicoleta Oancea, Claudiu Nicolicescu, Costel Valentin Manda, Johny Neamtu, Octavian Croitoru

Optimization of Gold Nanoparticles Synthesis using Design of Experiments Technique

Abstract:

Gold nanoparticles are considered the newest drug carriers for different diseases. Therefore it is appropriate continuous optimization of their preparation. In this study, gold colloids with an average size of 1 - 26 nm were obtained by the reduction of tetrachloroauric acid with trisodium citrate. The nanomaterials were characterized by UV-Vis spectroscopy and dynamic light scattering technique. In addition, zeta potential was measured for samples synthesized in order to determine the stability of the colloids. A Two-level Full Factorial design was chosen to determine the optimum set of process parameters (chloroauric acid concentration and sodium citrate concentration) and their effect on various gold nanoparticles characteristics (size and zeta potential). These effects were quantified using Design of Experiments (DoE) with 5 runs and 1 centerpoint. The selected objective and process model in this investigation are screening and interaction. Findings from this research show that to obtain particles larger than 35 nm, it is recommended to increase sodium citrate concentration, at low chloroauric acid values. These conditions will help to achieve smaller zeta potential, too.

Keywords:
gold nanoparticles; full factorial design; ultraviolet-visible spectroscopy; dynamic light scattering; zeta potential

Issue: 2017, Volume 68, Issue 7

Pages: 1518-1423

Publication date: 2017/8/15

https://doi.org/10.37358/RC.17.7.5707

Download Pdf Article

This article is published under the Creative Commons Attribution 4.0 International License

Citation Styles

Cite this article as:
STIOLICA, A.T., POPESCU, M., BUBULICA, M.V., OANCEA, C.N., NICOLICESCU, C., MANDA, C.V., NEAMTU, J., CROITORU, O., Optimization of Gold Nanoparticles Synthesis using Design of Experiments Technique, Rev. Chim., 68(7), 2017, 1518-1423.

Vancouver
Stiolica AT, Popescu M, Bubulica MV, Oancea CN, Nicolicescu C, Manda CV, Neamtu J, Croitoru O. Optimization of Gold Nanoparticles Synthesis using Design of Experiments Technique. Rev. Chim.[internet]. 2017 Jul;68(7):1518-1423. Available from: https://doi.org/10.37358/RC.17.7.5707

APA 6th edition
Stiolica, A.T., Popescu, M., Bubulica, M.V., Oancea, C.N., Nicolicescu, C., Manda, C.V., Neamtu, J. & Croitoru, O. (2017). Optimization of Gold Nanoparticles Synthesis using Design of Experiments Technique. Revista de Chimie, 68(7), 1518-1423. https://doi.org/10.37358/RC.17.7.5707

Harvard
Stiolica, A.T., Popescu, M., Bubulica, M.V., Oancea, C.N., Nicolicescu, C., Manda, C.V., Neamtu, J., Croitoru, O. (2017). 'Optimization of Gold Nanoparticles Synthesis using Design of Experiments Technique', Revista de Chimie, 68(7), pp. 1518-1423. https://doi.org/10.37358/RC.17.7.5707

IEEE
A.T. Stiolica, M. Popescu, M.V. Bubulica, C.N. Oancea, C. Nicolicescu, C.V. Manda, J. Neamtu, O. Croitoru, "Optimization of Gold Nanoparticles Synthesis using Design of Experiments Technique". Revista de Chimie, vol. 68, no. 7, pp. 1518-1423, 2017. [online]. https://doi.org/10.37358/RC.17.7.5707

Text
Adina Turcu Stiolica, Mariana Popescu, Maria Viorica Bubulica, Carmen Nicoleta Oancea, Claudiu Nicolicescu, Costel Valentin Manda, Johny Neamtu, Octavian Croitoru,
Optimization of Gold Nanoparticles Synthesis using Design of Experiments Technique,
Revista de Chimie,
Volume 68, Issue 7,
2017,
Pages 1518-1423,
ISSN 2668-8212,
https://doi.org/10.37358/RC.17.7.5707.
(https://revistadechimie.ro/Articles.asp?ID=5707)
Keywords: gold nanoparticles; full factorial design; ultraviolet-visible spectroscopy; dynamic light scattering; zeta potential

RIS
TY - JOUR
T1 - Optimization of Gold Nanoparticles Synthesis using Design of Experiments Technique
A1 - Stiolica, Adina Turcu
A2 - Popescu, Mariana
A3 - Bubulica, Maria Viorica
A4 - Oancea, Carmen Nicoleta
A5 - Nicolicescu, Claudiu
A6 - Manda, Costel Valentin
A7 - Neamtu, Johny
A8 - Croitoru, Octavian
JF - Revista de Chimie
JO - Rev. Chim.
PB - Revista de Chimie SRL
SN - 2668-8212
Y1 - 2017
VL - 68
IS - 7
SP - 1518
EP - 1423
UR - https://doi.org/10.37358/RC.17.7.5707
KW - gold nanoparticles
KW - full factorial design
KW - ultraviolet-visible spectroscopy
KW - dynamic light scattering
KW - zeta potential
ER -

BibTex
@article{RevCh2017P1518,
author = {Stiolica Adina Turcu and Popescu Mariana and Bubulica Maria Viorica and Oancea Carmen Nicoleta and Nicolicescu Claudiu and Manda Costel Valentin and Neamtu Johny and Croitoru Octavian},
title = {Optimization of Gold Nanoparticles Synthesis using Design of Experiments Technique},
journal = {Revista de Chimie},
volume = {68},
number = {7},
pages = {1518-1423},
year = {2017},
issn = {2668-8212},
doi = {https://doi.org/10.37358/RC.17.7.5707},
url = {https://revistadechimie.ro/Articles.asp?ID=5707}
}

<<<< back

PUBLISHING SECTION

Author Guidelines

* Paper Drafting

* Paper Template

* Ethical Statement

* Paper Submission

Ghidul Autorului (ro)

Open Access & Archiving Policy

Search Authors

LATEST NEWS
	NUMAR OMAGIAL PETRU PONI.. detalii
	Revista de Chimie - 70 de ani de aparitie neintrerupta.. detalii
	English-Romanian Dictionary for Mechanical Engineering (download pdf)