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https://doi.org/10.37358/Rev.Chim.1949

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Revista de Chimie (Rev. Chim.), Year 2017, Volume 68, Issue 7, 1591-1594

https://doi.org/10.37358/RC.17.7.5723

Cristina Furnica, Anton Knieling, Simona Irina Damian, Madalina Diac, Sofia David, Diana Bulgaru Iliescu, Ion Sandu, Catalin Jan Iov

Fatal Ethylene Glycol Intoxication Secondary to Accidental Ingestion

Abstract:

Ethylene glycol intoxication is potentially fatal and associated with typical clinical, laboratory and histopathological findings. The authors present the case of a 57-year-old male with a history of chronic alcoholism and who accidentally ingested approximately 1 litter of antifreeze solution. The patient was discovered comatose in his house and addressed to the emergency department with a Glasgow coma score of 3, severe metabolic acidosis, acute renal failure, atrial fibrillation and liver dysfunction. Despite reanimation manoeuvres and haemodialysis for 2 h the patient deceased 5 h after hospital admission. Necropsy examination revealed a stomach with oedematous walls, mucosa erosions and signs of bleeding together with a disorganised, granular single kidney with unidentifiable corticomedullary border. Histopathological examination displayed typical findings in the kidney such as autolytic changes of the epithelium and abundant calcium oxalate crystals in the lumen of the proximal tubules. Ethylene glycol intoxication is frequent in our country and its metabolites glycoaldehyde, glycolic acid, glyoxylic acid and oxalic acid are responsible for the severe metabolic acidosis and formation of calcium oxalate crystals in various organs and leading to severe multiple organ dysfunction and death. Forensic pathologists should be aware of clinical and biological manifestations as well as of typical histopathological findings as ethylene glycol is commonly ingested accidentally or used in homicidal/autolytical attempts.
Keywords:
ethylene glycol; intoxication; metabolic acidosis; calcium oxalate crystals; toxic metabolites

Issue: 2017, Volume 68, Issue 7
Pages: 1591-1594
Publication date: 2017/8/15
https://doi.org/10.37358/RC.17.7.5723
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Creative Commons License
This article is published under the Creative Commons Attribution 4.0 International License
Citation Styles
Cite this article as:
FURNICA, C., KNIELING, A., DAMIAN, S.I., DIAC, M., DAVID, S., ILIESCU, D.B., SANDU, I., IOV, C.J., Fatal Ethylene Glycol Intoxication Secondary to Accidental Ingestion, Rev. Chim., 68(7), 2017, 1591-1594.

Vancouver
Furnica C, Knieling A, Damian SI, Diac M, David S, Iliescu DB, Sandu I, Iov CJ. Fatal Ethylene Glycol Intoxication Secondary to Accidental Ingestion. Rev. Chim.[internet]. 2017 Jul;68(7):1591-1594. Available from: https://doi.org/10.37358/RC.17.7.5723


APA 6th edition
Furnica, C., Knieling, A., Damian, S.I., Diac, M., David, S., Iliescu, D.B., Sandu, I. & Iov, C.J. (2017). Fatal Ethylene Glycol Intoxication Secondary to Accidental Ingestion. Revista de Chimie, 68(7), 1591-1594. https://doi.org/10.37358/RC.17.7.5723


Harvard
Furnica, C., Knieling, A., Damian, S.I., Diac, M., David, S., Iliescu, D.B., Sandu, I., Iov, C.J. (2017). 'Fatal Ethylene Glycol Intoxication Secondary to Accidental Ingestion', Revista de Chimie, 68(7), pp. 1591-1594. https://doi.org/10.37358/RC.17.7.5723


IEEE
C. Furnica, A. Knieling, S.I. Damian, M. Diac, S. David, D.B. Iliescu, I. Sandu, C.J. Iov, "Fatal Ethylene Glycol Intoxication Secondary to Accidental Ingestion". Revista de Chimie, vol. 68, no. 7, pp. 1591-1594, 2017. [online]. https://doi.org/10.37358/RC.17.7.5723


Text
Cristina Furnica, Anton Knieling, Simona Irina Damian, Madalina Diac, Sofia David, Diana Bulgaru Iliescu, Ion Sandu, Catalin Jan Iov,
Fatal Ethylene Glycol Intoxication Secondary to Accidental Ingestion,
Revista de Chimie,
Volume 68, Issue 7,
2017,
Pages 1591-1594,
ISSN 2668-8212,
https://doi.org/10.37358/RC.17.7.5723.
(https://revistadechimie.ro/Articles.asp?ID=5723)
Keywords: ethylene glycol; intoxication; metabolic acidosis; calcium oxalate crystals; toxic metabolites


RIS
TY - JOUR
T1 - Fatal Ethylene Glycol Intoxication Secondary to Accidental Ingestion
A1 - Furnica, Cristina
A2 - Knieling, Anton
A3 - Damian, Simona Irina
A4 - Diac, Madalina
A5 - David, Sofia
A6 - Iliescu, Diana Bulgaru
A7 - Sandu, Ion
A8 - Iov, Catalin Jan
JF - Revista de Chimie
JO - Rev. Chim.
PB - Revista de Chimie SRL
SN - 2668-8212
Y1 - 2017
VL - 68
IS - 7
SP - 1591
EP - 1594
UR - https://doi.org/10.37358/RC.17.7.5723
KW - ethylene glycol
KW - intoxication
KW - metabolic acidosis
KW - calcium oxalate crystals
KW - toxic metabolites
ER -


BibTex
@article{RevCh2017P1591,
author = {Furnica Cristina and Knieling Anton and Damian Simona Irina and Diac Madalina and David Sofia and Iliescu Diana Bulgaru and Sandu Ion and Iov Catalin Jan},
title = {Fatal Ethylene Glycol Intoxication Secondary to Accidental Ingestion},
journal = {Revista de Chimie},
volume = {68},
number = {7},
pages = {1591-1594},
year = {2017},
issn = {2668-8212},
doi = {https://doi.org/10.37358/RC.17.7.5723},
url = {https://revistadechimie.ro/Articles.asp?ID=5723}
}
 
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