The Importance of Fluconazole in Treatment of Endogenous Endophtalmitis in Patients Prior Treated Using Negative Pressure Therapy for Wound Closure Contaminated with Meticillin-resistant Staphylococcus aureus

Alexa, Anisia Iuliana; Ciuntu, Roxana; Cantemir, Alina; Anton, Nicoleta; Danielescu, Ciprian; Negru, Robert; Bogdanici, Camelia Margareta; Vasiluta, Ciprian; Georgescu, Stefan Octavian; Sirbu, Paul Dan; Ciuntu, Bogdan Mihnea

Anisia Iuliana Alexa, Roxana Ciuntu, Alina Cantemir, Nicoleta Anton, Ciprian Danielescu, Robert Negru, Camelia Margareta Bogdanici, Ciprian Vasiluta, Stefan Octavian Georgescu, Paul Dan Sirbu, Bogdan Mihnea Ciuntu

The Importance of Fluconazole in Treatment of Endogenous Endophtalmitis in Patients Prior Treated Using Negative Pressure Therapy for Wound Closure Contaminated with Meticillin-resistant Staphylococcus aureus

Abstract:

Severe infections with C. albicans should be treated promptly with antifungal agents, any delay in treatment increases the risk of endophthalmitis. The systemic Amphotericin B therapy is the gold standard in the treatment of endophthalmitis, but in the case of fungal infections it has not yet been determined. Numerous studies have shown that the use of Fluconazole is effective in the treatment of fungal endophthalmitis. In this paper, we report two cases (3 eyes) that have been presented for the same accusations of significant decrease of AV (visual acuity), ocular pain and blepharospasm suddenly installed, both of which required urgent antibiotic and intravenous antifungal treatment. Both are diagnosed with endogenous endophthalmitis and vitreous biopsy + VPP (pars plana vitrectomy) are performed, with a negative result of the vitreous culture. In both situations the treatment was with antibiotic and systemic antifungals. Postoperatively, evolution was favorable in the first case and less favorable in the second one. The prognosis depends on the virulence of the microorganisms and the time elapsed until initiation of the treatment. Also, the presence of risk factors such as diabetes, sepsis, recent abdominal surgery (C. Albicans is part of the comesary flora of the digestive tract) have influenced the prognosis decisively. Severe infections with C. albicans should be promptly treated with antifungal agents, any delay in treatment increases the risk of endophthalmitis. Even when prolonged treatment of candidemia is instituted, 3% of patients can develop endogenous endophthalmitis, so ocular evaluation is particularly important for patients immobilized in anesthesia and intensive care units.

Keywords:
fluconazole; endogenous endophthalmitis; candida albicans; negative pressure therapy

Issue: 2017, Volume 68, Issue 7

Pages: 1598-1601

Publication date: 2017/8/15

https://doi.org/10.37358/RC.17.7.5725

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This article is published under the Creative Commons Attribution 4.0 International License

Citation Styles

Cite this article as:
ALEXA, A.I., CIUNTU, R., CANTEMIR, A., ANTON, N., DANIELESCU, C., NEGRU, R., BOGDANICI, C.M., VASILUTA, C., GEORGESCU, S.O., SIRBU, P.D., CIUNTU, B.M., The Importance of Fluconazole in Treatment of Endogenous Endophtalmitis in Patients Prior Treated Using Negative Pressure Therapy for Wound Closure Contaminated with Meticillin-resistant Staphylococcus aureus, Rev. Chim., 68(7), 2017, 1598-1601.

Vancouver
Alexa AI, Ciuntu R, Cantemir A, Anton N, Danielescu C, Negru R, Bogdanici CM, Vasiluta C, Georgescu SO, Sirbu PD, Ciuntu BM. The Importance of Fluconazole in Treatment of Endogenous Endophtalmitis in Patients Prior Treated Using Negative Pressure Therapy for Wound Closure Contaminated with Meticillin-resistant Staphylococcus aureus. Rev. Chim.[internet]. 2017 Jul;68(7):1598-1601. Available from: https://doi.org/10.37358/RC.17.7.5725

APA 6th edition
Alexa, A.I., Ciuntu, R., Cantemir, A., Anton, N., Danielescu, C., Negru, R.,... Ciuntu, B.M. (2017). The Importance of Fluconazole in Treatment of Endogenous Endophtalmitis in Patients Prior Treated Using Negative Pressure Therapy for Wound Closure Contaminated with Meticillin-resistant Staphylococcus aureus. Revista de Chimie, 68(7), 1598-1601. https://doi.org/10.37358/RC.17.7.5725

Harvard
Alexa, A.I., Ciuntu, R., Cantemir, A., Anton, N., Danielescu, C., Negru, R., Bogdanici, C.M., Vasiluta, C., Georgescu, S.O., Sirbu, P.D., Ciuntu, B.M. (2017). 'The Importance of Fluconazole in Treatment of Endogenous Endophtalmitis in Patients Prior Treated Using Negative Pressure Therapy for Wound Closure Contaminated with Meticillin-resistant Staphylococcus aureus', Revista de Chimie, 68(7), pp. 1598-1601. https://doi.org/10.37358/RC.17.7.5725

IEEE
A.I. Alexa, R. Ciuntu, A. Cantemir, N. Anton, C. Danielescu, R. Negru, C.M. Bogdanici, C. Vasiluta, S.O. Georgescu, P.D. Sirbu, B.M. Ciuntu, "The Importance of Fluconazole in Treatment of Endogenous Endophtalmitis in Patients Prior Treated Using Negative Pressure Therapy for Wound Closure Contaminated with Meticillin-resistant Staphylococcus aureus". Revista de Chimie, vol. 68, no. 7, pp. 1598-1601, 2017. [online]. https://doi.org/10.37358/RC.17.7.5725

Text
Anisia Iuliana Alexa, Roxana Ciuntu, Alina Cantemir, Nicoleta Anton, Ciprian Danielescu, Robert Negru, Camelia Margareta Bogdanici, Ciprian Vasiluta, Stefan Octavian Georgescu, Paul Dan Sirbu, Bogdan Mihnea Ciuntu,
The Importance of Fluconazole in Treatment of Endogenous Endophtalmitis in Patients Prior Treated Using Negative Pressure Therapy for Wound Closure Contaminated with Meticillin-resistant Staphylococcus aureus,
Revista de Chimie,
Volume 68, Issue 7,
2017,
Pages 1598-1601,
ISSN 2668-8212,
https://doi.org/10.37358/RC.17.7.5725.
(https://revistadechimie.ro/Articles.asp?ID=5725)
Keywords: fluconazole; endogenous endophthalmitis; candida albicans; negative pressure therapy

RIS
TY - JOUR
T1 - The Importance of Fluconazole in Treatment of Endogenous Endophtalmitis in Patients Prior Treated Using Negative Pressure Therapy for Wound Closure Contaminated with Meticillin-resistant Staphylococcus aureus
A1 - Alexa, Anisia Iuliana
A2 - Ciuntu, Roxana
A3 - Cantemir, Alina
A4 - Anton, Nicoleta
A5 - Danielescu, Ciprian
A6 - Negru, Robert
A7 - Bogdanici, Camelia Margareta
A8 - Vasiluta, Ciprian
A9 - Georgescu, Stefan Octavian
A10 - Sirbu, Paul Dan
A11 - Ciuntu, Bogdan Mihnea
JF - Revista de Chimie
JO - Rev. Chim.
PB - Revista de Chimie SRL
SN - 2668-8212
Y1 - 2017
VL - 68
IS - 7
SP - 1598
EP - 1601
UR - https://doi.org/10.37358/RC.17.7.5725
KW - fluconazole
KW - endogenous endophthalmitis
KW - candida albicans
KW - negative pressure therapy
ER -

BibTex
@article{RevCh2017P1598,
author = {Alexa Anisia Iuliana and Ciuntu Roxana and Cantemir Alina and Anton Nicoleta and Danielescu Ciprian and Negru Robert and Bogdanici Camelia Margareta and Vasiluta Ciprian and Georgescu Stefan Octavian and Sirbu Paul Dan and Ciuntu Bogdan Mihnea},
title = {The Importance of Fluconazole in Treatment of Endogenous Endophtalmitis in Patients Prior Treated Using Negative Pressure Therapy for Wound Closure Contaminated with Meticillin-resistant Staphylococcus aureus},
journal = {Revista de Chimie},
volume = {68},
number = {7},
pages = {1598-1601},
year = {2017},
issn = {2668-8212},
doi = {https://doi.org/10.37358/RC.17.7.5725},
url = {https://revistadechimie.ro/Articles.asp?ID=5725}
}

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