Selenium- Essential Antioxidant Element. The example of autoimune thyroiditis

Preda, Cristina; Vasiliu, Ioana; Mihalache, Laura; Armasu, Ioana; Serban, Ionela Lacramioara; Serban, Dragomir Nicolae; Stoica, Bogdan; Ciobanu, Delia Gabriela; Bredetean, Ovidiu; Strungaru, Stefan Adrian; Nicoara, Mircea; Plavan, Gabriel; Vulpoi, Carmen

Cristina Preda, Ioana Vasiliu, Laura Mihalache, Ioana Armasu, Ionela Lacramioara Serban, Dragomir Nicolae Serban, Bogdan Stoica, Delia Gabriela Ciobanu, Ovidiu Bredetean, Stefan Adrian Strungaru, Mircea Nicoara, Gabriel Plavan, Carmen Vulpoi

Selenium- Essential Antioxidant Element. The example of autoimune thyroiditis

Abstract:

To evaluate the effect of Selenium (Se) supplementation on: thyroid stimulating hormone (TSH), antiperoxidase antibodies (TPOAb) and glutathione peroxidise 1 (GPx1) in euthyroid subjects with autoimmune thyroiditis. 100 euthyroid women with autoimmune thyroiditis, from the same region, were randomized to receive daily 100 mg selenomethionine (n=50) or placebo (n=50) for 3 months. Serum concentrations of Se, TPOAb and TSH were performed in all patients at baseline and after 3 months. GPx1 activity was measured only in the interventional group before and after Se supplementation. At 3 months TSH presented a significant increase both in treated (2.49 vs. 2.09 UI/mL; p=0.001) and untreated groups (2.38 vs. 1.91 UI/mL; p=0.008). TPOAb decreased by 15.2% in patients treated with Se (p=0.002) and were not modified in untreated patients. At the end of the study Se and TPOAb were in direct insignificant correlation (r=+0.267, p=0.105). GPx1 did not show significant changes after Se supplementation. After 3 months of Se supplementation results showed a mild decrease of TPOAb and a weak negative correlation of these antibodies with Se levels. This suggests that Se treatment may improve the course of thyroid autoimmunity.

Keywords:
Selenium; glutathione peroxidase; autoimmune thyroiditis; oxidative stress

Issue: 2017, Volume 68, Issue 7

Pages: 1617-1621

Publication date: 2017/8/15

https://doi.org/10.37358/RC.17.7.5729

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This article is published under the Creative Commons Attribution 4.0 International License

Citation Styles

Cite this article as:
PREDA, C., VASILIU, I., MIHALACHE, L., ARMASU, I., SERBAN, I.L., SERBAN, D.N., STOICA, B., CIOBANU, D.G., BREDETEAN, O., STRUNGARU, S.A., NICOARA, M., PLAVAN, G., VULPOI, C., Selenium- Essential Antioxidant Element. The example of autoimune thyroiditis, Rev. Chim., 68(7), 2017, 1617-1621.

Vancouver
Preda C, Vasiliu I, Mihalache L, Armasu I, Serban IL, Serban DN, Stoica B, Ciobanu DG, Bredetean O, Strungaru SA, Nicoara M, Plavan G, Vulpoi C. Selenium- Essential Antioxidant Element. The example of autoimune thyroiditis. Rev. Chim.[internet]. 2017 Jul;68(7):1617-1621. Available from: https://doi.org/10.37358/RC.17.7.5729

APA 6th edition
Preda, C., Vasiliu, I., Mihalache, L., Armasu, I., Serban, I.L., Serban, D.N.,... Vulpoi, C. (2017). Selenium- Essential Antioxidant Element. The example of autoimune thyroiditis. Revista de Chimie, 68(7), 1617-1621. https://doi.org/10.37358/RC.17.7.5729

Harvard
Preda, C., Vasiliu, I., Mihalache, L., Armasu, I., Serban, I.L., Serban, D.N., Stoica, B., Ciobanu, D.G., Bredetean, O., Strungaru, S.A., Nicoara, M., Plavan, G., Vulpoi, C. (2017). 'Selenium- Essential Antioxidant Element. The example of autoimune thyroiditis', Revista de Chimie, 68(7), pp. 1617-1621. https://doi.org/10.37358/RC.17.7.5729

IEEE
C. Preda, I. Vasiliu, L. Mihalache, I. Armasu, I.L. Serban, D.N. Serban, B. Stoica, D.G. Ciobanu, O. Bredetean, S.A. Strungaru, M. Nicoara, G. Plavan, C. Vulpoi, "Selenium- Essential Antioxidant Element. The example of autoimune thyroiditis". Revista de Chimie, vol. 68, no. 7, pp. 1617-1621, 2017. [online]. https://doi.org/10.37358/RC.17.7.5729

Text
Cristina Preda, Ioana Vasiliu, Laura Mihalache, Ioana Armasu, Ionela Lacramioara Serban, Dragomir Nicolae Serban, Bogdan Stoica, Delia Gabriela Ciobanu, Ovidiu Bredetean, Stefan Adrian Strungaru, Mircea Nicoara, Gabriel Plavan, Carmen Vulpoi,
Selenium- Essential Antioxidant Element. The example of autoimune thyroiditis,
Revista de Chimie,
Volume 68, Issue 7,
2017,
Pages 1617-1621,
ISSN 2668-8212,
https://doi.org/10.37358/RC.17.7.5729.
(https://revistadechimie.ro/Articles.asp?ID=5729)
Keywords: Selenium; glutathione peroxidase; autoimmune thyroiditis; oxidative stress

RIS
TY - JOUR
T1 - Selenium- Essential Antioxidant Element. The example of autoimune thyroiditis
A1 - Preda, Cristina
A2 - Vasiliu, Ioana
A3 - Mihalache, Laura
A4 - Armasu, Ioana
A5 - Serban, Ionela Lacramioara
A6 - Serban, Dragomir Nicolae
A7 - Stoica, Bogdan
A8 - Ciobanu, Delia Gabriela
A9 - Bredetean, Ovidiu
A10 - Strungaru, Stefan Adrian
A11 - Nicoara, Mircea
A12 - Plavan, Gabriel
A13 - Vulpoi, Carmen
JF - Revista de Chimie
JO - Rev. Chim.
PB - Revista de Chimie SRL
SN - 2668-8212
Y1 - 2017
VL - 68
IS - 7
SP - 1617
EP - 1621
UR - https://doi.org/10.37358/RC.17.7.5729
KW - Selenium
KW - glutathione peroxidase
KW - autoimmune thyroiditis
KW - oxidative stress
ER -

BibTex
@article{RevCh2017P1617,
author = {Preda Cristina and Vasiliu Ioana and Mihalache Laura and Armasu Ioana and Serban Ionela Lacramioara and Serban Dragomir Nicolae and Stoica Bogdan and Ciobanu Delia Gabriela and Bredetean Ovidiu and Strungaru Stefan Adrian and Nicoara Mircea and Plavan Gabriel and Vulpoi Carmen},
title = {Selenium- Essential Antioxidant Element. The example of autoimune thyroiditis},
journal = {Revista de Chimie},
volume = {68},
number = {7},
pages = {1617-1621},
year = {2017},
issn = {2668-8212},
doi = {https://doi.org/10.37358/RC.17.7.5729},
url = {https://revistadechimie.ro/Articles.asp?ID=5729}
}

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