RAZVAN HAINAROSIE, VIOREL ZAINEA, MURA HAINAROSIE, CATALINA PIETROSANU, IRINA IONITA DISEASE FREE MARGINS ASSESSMENT USING ENHANCED METHYLENE BLUE VIDEO CONTACT ENDOSCOPY WITH SPIES FILTERS IN VOCAL FOLD MALIGNANCIES Vocal fold carcinomas represent a pathology that has an important incidence. Recent studies showed that 70% of the dysplastic lesions can skip the phases of mild and severe dysplasia directly to carcinoma. For that reason early detection of a malignancy of the vocal fold is mandatory. If the lesion is discovered in an early stage it must be aggressively treated using CO2 LASER surgery and disease free margins must be obtained. Because frozen sections are not always available in all medical centers we are proposing a new protocol to assess disease free margins during CO2 LASER assisted laryngoscopy. Methylene blue contact endoscopy is not a new method, as it was introduced in laryngology by professors Oscar Diaz and Mario Andreea in 1994. We are proposing a protocol designed to assess disease free margins using an enhanced video contact endoscopy with SPIES software filters. The SPIES filters technology is a relatively new technology proposed by Karl Storz in 2013. A critical analysis of the method will be done comparing the results with paraffin histopathology exam.