Implications of Creatinine and ALP in the Induction of Osteoporosis by Ovariectomy in Female Wistar Rats

Lazar, Adela Cristina; Lacatus, Radu; Purdoiu, Robert; Bel, Lucia; Sarpataki, Orsolya; Papuc, Ionel; Pacurar, Mariana; Campian, Radu Septimiu

Adela Cristina Lazar, Radu Lacatus, Robert Purdoiu, Lucia Bel, Orsolya Sarpataki, Ionel Papuc, Mariana Pacurar, Radu Septimiu Campian

Implications of Creatinine and ALP in the Induction of Osteoporosis by Ovariectomy in Female Wistar Rats

Abstract:

Histological and biochemical assessment of maxillary bone necrosis induced by therapy with two bisphosphonate types used to treat osteoporosis induced in female Wistar rats, evaluation of effects on creatinine and ALP values at different time intervals. Female Wistar rats were ovariectomized to induce osteoporosis. Blood tests for ALP and creatinine were conducted. They received two types of bisphosphonates. Dental extraction was performed in each rat separately; finally, the rats were euthanized. Microscopic evaluation of the tissue fragments collected from the groups of rats was performed for the following parameters: degree of osteonecrosis, bone resorption, inflammatory infiltrate with neutrophils and mononuclear cells, number of osteoclasts, degree of proliferation of fibrous connective tissue, and local neovascularization. The biochemical and subsequently histological investigations for osteonecrosis of the jaw associated with bisphosphonate therapy in rats with induced osteoporosis provide accurate information about the extent of osteonecrosis, bone resorption, inflammatory infiltrate with mononuclear cells and neutrophils, number of osteoclasts, degree of proliferation of fibrous connective tissue, and local neovascularization. This is necessary for positive and differential diagnosis and for the treatment plan.

Keywords:
alkaline phosphatase; creatinine; osteoporosis; rats; bone necrosis

Issue: 2017, Volume 68, Issue 8

Pages: 1799-1803

Publication date: 2017/9/15

https://doi.org/10.37358/RC.17.8.5768

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This article is published under the Creative Commons Attribution 4.0 International License

Citation Styles

Cite this article as:
LAZAR, A.C., LACATUS, R., PURDOIU, R., BEL, L., SARPATAKI, O., PAPUC, I., PACURAR, M., CAMPIAN, R.S., Implications of Creatinine and ALP in the Induction of Osteoporosis by Ovariectomy in Female Wistar Rats, Rev. Chim., 68(8), 2017, 1799-1803.

Vancouver
Lazar AC, Lacatus R, Purdoiu R, Bel L, Sarpataki O, Papuc I, Pacurar M, Campian RS. Implications of Creatinine and ALP in the Induction of Osteoporosis by Ovariectomy in Female Wistar Rats. Rev. Chim.[internet]. 2017 Aug;68(8):1799-1803. Available from: https://doi.org/10.37358/RC.17.8.5768

APA 6th edition
Lazar, A.C., Lacatus, R., Purdoiu, R., Bel, L., Sarpataki, O., Papuc, I., Pacurar, M. & Campian, R.S. (2017). Implications of Creatinine and ALP in the Induction of Osteoporosis by Ovariectomy in Female Wistar Rats. Revista de Chimie, 68(8), 1799-1803. https://doi.org/10.37358/RC.17.8.5768

Harvard
Lazar, A.C., Lacatus, R., Purdoiu, R., Bel, L., Sarpataki, O., Papuc, I., Pacurar, M., Campian, R.S. (2017). 'Implications of Creatinine and ALP in the Induction of Osteoporosis by Ovariectomy in Female Wistar Rats', Revista de Chimie, 68(8), pp. 1799-1803. https://doi.org/10.37358/RC.17.8.5768

IEEE
A.C. Lazar, R. Lacatus, R. Purdoiu, L. Bel, O. Sarpataki, I. Papuc, M. Pacurar, R.S. Campian, "Implications of Creatinine and ALP in the Induction of Osteoporosis by Ovariectomy in Female Wistar Rats". Revista de Chimie, vol. 68, no. 8, pp. 1799-1803, 2017. [online]. https://doi.org/10.37358/RC.17.8.5768

Text
Adela Cristina Lazar, Radu Lacatus, Robert Purdoiu, Lucia Bel, Orsolya Sarpataki, Ionel Papuc, Mariana Pacurar, Radu Septimiu Campian,
Implications of Creatinine and ALP in the Induction of Osteoporosis by Ovariectomy in Female Wistar Rats,
Revista de Chimie,
Volume 68, Issue 8,
2017,
Pages 1799-1803,
ISSN 2668-8212,
https://doi.org/10.37358/RC.17.8.5768.
(https://revistadechimie.ro/Articles.asp?ID=5768)
Keywords: alkaline phosphatase; creatinine; osteoporosis; rats; bone necrosis

RIS
TY - JOUR
T1 - Implications of Creatinine and ALP in the Induction of Osteoporosis by Ovariectomy in Female Wistar Rats
A1 - Lazar, Adela Cristina
A2 - Lacatus, Radu
A3 - Purdoiu, Robert
A4 - Bel, Lucia
A5 - Sarpataki, Orsolya
A6 - Papuc, Ionel
A7 - Pacurar, Mariana
A8 - Campian, Radu Septimiu
JF - Revista de Chimie
JO - Rev. Chim.
PB - Revista de Chimie SRL
SN - 2668-8212
Y1 - 2017
VL - 68
IS - 8
SP - 1799
EP - 1803
UR - https://doi.org/10.37358/RC.17.8.5768
KW - alkaline phosphatase
KW - creatinine
KW - osteoporosis
KW - rats
KW - bone necrosis
ER -

BibTex
@article{RevCh2017P1799,
author = {Lazar Adela Cristina and Lacatus Radu and Purdoiu Robert and Bel Lucia and Sarpataki Orsolya and Papuc Ionel and Pacurar Mariana and Campian Radu Septimiu},
title = {Implications of Creatinine and ALP in the Induction of Osteoporosis by Ovariectomy in Female Wistar Rats},
journal = {Revista de Chimie},
volume = {68},
number = {8},
pages = {1799-1803},
year = {2017},
issn = {2668-8212},
doi = {https://doi.org/10.37358/RC.17.8.5768},
url = {https://revistadechimie.ro/Articles.asp?ID=5768}
}

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