The Contribution of Histochemical and Immunohistochemical Techniques in Assessing the Proliferative Capacity and Prognosis for Renal Cell Carcinoma

Puscasiu, Daniela Anca; Tanasie, Gabriela; Georgescu, Marius; Tatu, Romulus Fabian; Tatu, Carmen Sofica

Daniela Anca Puscasiu, Gabriela Tanasie, Marius Georgescu, Romulus Fabian Tatu, Carmen Sofica Tatu

The Contribution of Histochemical and Immunohistochemical Techniques in Assessing the Proliferative Capacity and Prognosis for Renal Cell Carcinoma

Abstract:

The drive to prolong life and to improve life quality in patients suffering from cancer forms of any kind means that, aside from the necessary treatment, prognostic evaluations are needed. In our present study we included 63 patients with renal cell carcinoma. The histological samples obtained in surgery were studied through the classical histopathology methods, histochemical and immunohistochemical techniques. The histological degree of tumor differentiation was assessed for all cases, falling within all 4 classification grades. The immunohistochemical reaction for PCNA (proliferating cell nuclear antigen) was performed, utilizing the PC 10-LSAB antibody through visualization with the LSAB-DAB kit. This was the method used for assessing the process of tumor proliferation. Subsequently, the histological degree of differentiation was correlated with the PCNA score. We anticipate a reserved prognosis for patients with a positive expression on most tumor cells, which represents a high PCNA score.

Keywords:
renal cell carcinoma; histochemical techniques; immunohistochemical staining; histopathological differentiation grade; PCNA score

Issue: 2017, Volume 68, Issue 8

Pages: 1804-1806

Publication date: 2017/9/15

https://doi.org/10.37358/RC.17.8.5769

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This article is published under the Creative Commons Attribution 4.0 International License

Citation Styles

Cite this article as:
PUSCASIU, D.A., TANASIE, G., GEORGESCU, M., TATU, R.F., TATU, C.S., The Contribution of Histochemical and Immunohistochemical Techniques in Assessing the Proliferative Capacity and Prognosis for Renal Cell Carcinoma, Rev. Chim., 68(8), 2017, 1804-1806.

Vancouver
Puscasiu DA, Tanasie G, Georgescu M, Tatu RF, Tatu CS. The Contribution of Histochemical and Immunohistochemical Techniques in Assessing the Proliferative Capacity and Prognosis for Renal Cell Carcinoma. Rev. Chim.[internet]. 2017 Aug;68(8):1804-1806. Available from: https://doi.org/10.37358/RC.17.8.5769

APA 6th edition
Puscasiu, D.A., Tanasie, G., Georgescu, M., Tatu, R.F. & Tatu, C.S. (2017). The Contribution of Histochemical and Immunohistochemical Techniques in Assessing the Proliferative Capacity and Prognosis for Renal Cell Carcinoma. Revista de Chimie, 68(8), 1804-1806. https://doi.org/10.37358/RC.17.8.5769

Harvard
Puscasiu, D.A., Tanasie, G., Georgescu, M., Tatu, R.F., Tatu, C.S. (2017). 'The Contribution of Histochemical and Immunohistochemical Techniques in Assessing the Proliferative Capacity and Prognosis for Renal Cell Carcinoma', Revista de Chimie, 68(8), pp. 1804-1806. https://doi.org/10.37358/RC.17.8.5769

IEEE
D.A. Puscasiu, G. Tanasie, M. Georgescu, R.F. Tatu, C.S. Tatu, "The Contribution of Histochemical and Immunohistochemical Techniques in Assessing the Proliferative Capacity and Prognosis for Renal Cell Carcinoma". Revista de Chimie, vol. 68, no. 8, pp. 1804-1806, 2017. [online]. https://doi.org/10.37358/RC.17.8.5769

Text
Daniela Anca Puscasiu, Gabriela Tanasie, Marius Georgescu, Romulus Fabian Tatu, Carmen Sofica Tatu,
The Contribution of Histochemical and Immunohistochemical Techniques in Assessing the Proliferative Capacity and Prognosis for Renal Cell Carcinoma,
Revista de Chimie,
Volume 68, Issue 8,
2017,
Pages 1804-1806,
ISSN 2668-8212,
https://doi.org/10.37358/RC.17.8.5769.
(https://revistadechimie.ro/Articles.asp?ID=5769)
Keywords: renal cell carcinoma; histochemical techniques; immunohistochemical staining; histopathological differentiation grade; PCNA score

RIS
TY - JOUR
T1 - The Contribution of Histochemical and Immunohistochemical Techniques in Assessing the Proliferative Capacity and Prognosis for Renal Cell Carcinoma
A1 - Puscasiu, Daniela Anca
A2 - Tanasie, Gabriela
A3 - Georgescu, Marius
A4 - Tatu, Romulus Fabian
A5 - Tatu, Carmen Sofica
JF - Revista de Chimie
JO - Rev. Chim.
PB - Revista de Chimie SRL
SN - 2668-8212
Y1 - 2017
VL - 68
IS - 8
SP - 1804
EP - 1806
UR - https://doi.org/10.37358/RC.17.8.5769
KW - renal cell carcinoma
KW - histochemical techniques
KW - immunohistochemical staining
KW - histopathological differentiation grade
KW - PCNA score
ER -

BibTex
@article{RevCh2017P1804,
author = {Puscasiu Daniela Anca and Tanasie Gabriela and Georgescu Marius and Tatu Romulus Fabian and Tatu Carmen Sofica},
title = {The Contribution of Histochemical and Immunohistochemical Techniques in Assessing the Proliferative Capacity and Prognosis for Renal Cell Carcinoma},
journal = {Revista de Chimie},
volume = {68},
number = {8},
pages = {1804-1806},
year = {2017},
issn = {2668-8212},
doi = {https://doi.org/10.37358/RC.17.8.5769},
url = {https://revistadechimie.ro/Articles.asp?ID=5769}
}

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