ADRIANA SARAH NICA, ROXANA NARTEA, DACIANA ANDRADA COSTINA STEFAN, ROXANA MICLAUS LINK BETWEEN BIOCHEMICAL, BIOLOGICAL AND CLINICAL ASSESSMENT FOCUSED ON POLYCYTHEMIA VERA AND STROKE This case presentation is of a 58 years old female patient who develops a stroke in 2011 with significant biochemical and biological changes. These manifestations prove to be the result of a hematology disorder, more precise a myeloproliferative neoplasm, Polycythemia Vera. The disease was unidentified and with non-specific symptomology until the occurrence of stroke. The particularity of this case is the presence of severe cardiovascular disease (stage III hypertension. Obstructive hypertrophic cardiomyopathy, chronic ischemic silent disease), with cerebral manifestations (stroke) and associated with mixt hepatitis (alcoholic and deficiency), hypercholesterolemia and hyperuricemia. This biological context represent a real challenge both etiologically and therapeutically (pharmacology and non-pharmacology).