The Efficiency of Recombinant Alpha Eptacog in Haemostatis Management of Haemophilic Patients with Elective Arthroplasty

Badulescu, Oana Viola; Tudor, Razvan; Blaj, Mihaela; Ciuntu, Bogdan Mihnea; Sirbu, Paul Dan

Oana Viola Badulescu, Razvan Tudor, Mihaela Blaj, Bogdan Mihnea Ciuntu, Paul Dan Sirbu

The Efficiency of Recombinant Alpha Eptacog in Haemostatis Management of Haemophilic Patients with Elective Arthroplasty

Abstract:

Haemophilia is considered to be the most severe coagulopathy, characterized by a deficiency either of factor VIII (hemophilia A) or coagulation factor IX (hemophilia B), presenting various degrees of severity depending on the residual factor level. Haemarthrosis is the most common clinical expression of a haemophiliac patient. Its repetitive character will cause irreversible lesions in the joints, which mark the beginning of a chronic condition - haemophiliac arthropathy, which slowly develops throughout the patient’s life, leading eventually to ankylosis. Over time, these joints will require total prosthesis, in order to improve locomotor activity. Achieving effective hemostasis is an essential element for the possibility of performing this type of surgery, due to the increased risk of bleeding, of a vital nature, at this category of patients. A series of clinical trials have been carried out to research the role of the Eptacog Alpha Recombinant treatment in the reduction of bleeding in haemophiliac patients with present inhibitors, to whom total arthroplasty is carried out at the level of various joints. In this regard, this paper aims to highlight the effectiveness of Eptacog Alpha Recombinant in the management of haemostasis in haemophiliac patients, with indication of total endoprosthesis.

Keywords:
Haemophilia; Eptacog Alpha Recombinant; anti-factor VIII antibodies; total arthroplasty

Issue: 2017, Volume 68, Issue 8

Pages: 1931-1934

Publication date: 2017/9/15

https://doi.org/10.37358/RC.17.8.5794

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This article is published under the Creative Commons Attribution 4.0 International License

Citation Styles

Cite this article as:
BADULESCU, O.V., TUDOR, R., BLAJ, M., CIUNTU, B.M., SIRBU, P.D., The Efficiency of Recombinant Alpha Eptacog in Haemostatis Management of Haemophilic Patients with Elective Arthroplasty, Rev. Chim., 68(8), 2017, 1931-1934.

Vancouver
Badulescu OV, Tudor R, Blaj M, Ciuntu BM, Sirbu PD. The Efficiency of Recombinant Alpha Eptacog in Haemostatis Management of Haemophilic Patients with Elective Arthroplasty. Rev. Chim.[internet]. 2017 Aug;68(8):1931-1934. Available from: https://doi.org/10.37358/RC.17.8.5794

APA 6th edition
Badulescu, O.V., Tudor, R., Blaj, M., Ciuntu, B.M. & Sirbu, P.D. (2017). The Efficiency of Recombinant Alpha Eptacog in Haemostatis Management of Haemophilic Patients with Elective Arthroplasty. Revista de Chimie, 68(8), 1931-1934. https://doi.org/10.37358/RC.17.8.5794

Harvard
Badulescu, O.V., Tudor, R., Blaj, M., Ciuntu, B.M., Sirbu, P.D. (2017). 'The Efficiency of Recombinant Alpha Eptacog in Haemostatis Management of Haemophilic Patients with Elective Arthroplasty', Revista de Chimie, 68(8), pp. 1931-1934. https://doi.org/10.37358/RC.17.8.5794

IEEE
O.V. Badulescu, R. Tudor, M. Blaj, B.M. Ciuntu, P.D. Sirbu, "The Efficiency of Recombinant Alpha Eptacog in Haemostatis Management of Haemophilic Patients with Elective Arthroplasty". Revista de Chimie, vol. 68, no. 8, pp. 1931-1934, 2017. [online]. https://doi.org/10.37358/RC.17.8.5794

Text
Oana Viola Badulescu, Razvan Tudor, Mihaela Blaj, Bogdan Mihnea Ciuntu, Paul Dan Sirbu,
The Efficiency of Recombinant Alpha Eptacog in Haemostatis Management of Haemophilic Patients with Elective Arthroplasty,
Revista de Chimie,
Volume 68, Issue 8,
2017,
Pages 1931-1934,
ISSN 2668-8212,
https://doi.org/10.37358/RC.17.8.5794.
(https://revistadechimie.ro/Articles.asp?ID=5794)
Keywords: Haemophilia; Eptacog Alpha Recombinant; anti-factor VIII antibodies; total arthroplasty

RIS
TY - JOUR
T1 - The Efficiency of Recombinant Alpha Eptacog in Haemostatis Management of Haemophilic Patients with Elective Arthroplasty
A1 - Badulescu, Oana Viola
A2 - Tudor, Razvan
A3 - Blaj, Mihaela
A4 - Ciuntu, Bogdan Mihnea
A5 - Sirbu, Paul Dan
JF - Revista de Chimie
JO - Rev. Chim.
PB - Revista de Chimie SRL
SN - 2668-8212
Y1 - 2017
VL - 68
IS - 8
SP - 1931
EP - 1934
UR - https://doi.org/10.37358/RC.17.8.5794
KW - Haemophilia
KW - Eptacog Alpha Recombinant
KW - anti-factor VIII antibodies
KW - total arthroplasty
ER -

BibTex
@article{RevCh2017P1931,
author = {Badulescu Oana Viola and Tudor Razvan and Blaj Mihaela and Ciuntu Bogdan Mihnea and Sirbu Paul Dan},
title = {The Efficiency of Recombinant Alpha Eptacog in Haemostatis Management of Haemophilic Patients with Elective Arthroplasty},
journal = {Revista de Chimie},
volume = {68},
number = {8},
pages = {1931-1934},
year = {2017},
issn = {2668-8212},
doi = {https://doi.org/10.37358/RC.17.8.5794},
url = {https://revistadechimie.ro/Articles.asp?ID=5794}
}

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