ANDRADA IFTODE, TEODORA DANIELA MARTI, MIRELA VOICU, SEBASTIAN SIMU, ALINA HEGHES, FLORIN BORCAN, ANDREI MOTOC EVALUATION OF A SKIN CARCINOMA XENOGRAFT MICE MODEL SUPPLEMENTED BY CHEMICAL IMMUNOSUPPRESSION As we know today, cancer is a disease caused by the uncontrolled growth of a single cell. This development is triggered by mutations, changes in DNA that affect genes in such a way that they increase cancer cells. In the present study, an experimental model based on skin carcinoma xenograft mice was developed and tested. There were studied: the mice weight, the tumor volume, and the evolution of different skin parameters such as transepidermal water loss (TWL), erythema and the hydration level of stratum corneum; mice were divided in four groups: a control group, a group of mice injected with physiological saline solution, another one with immunosuppression, and a group of mice with immunosuppression and xenograft of A375 cells. The results indicate that administration of cyclophosphamide significantly reduced the number of neutrophils and lymphocytes and last two mice groups revealed more pronounced modifications of skin parameters compared to first two groups.