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https://doi.org/10.37358/Rev.Chim.1949

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Revista de Chimie (Rev. Chim.), Year 2017, Volume 68, Issue 10, 2284-2288

https://doi.org/10.37358/RC.17.10.5871

Amelia Tero Vescan, Bianca Eugenia Osz, Anca Maier, Silvia Imre, Alina Ormenisan, Violeta Hancu, Camil Eugen Vari

Concomitant Quantification of Caffeine, Cotinine and N-methyl Uric Acid in Urine. Applications for athlete monitoring and pharmacological screening

Abstract:

Simultaneous determination of caffeine, cotinine, and 1N-methyluric acid in urine has numerous applications in determining patterns of use by athletes, according to the World Anti-Doping Agency (WADA) which includes these substances on the Monitoring List. The method can provide information on the enzyme-inducing activity on CYP1A2 of polycyclic aromatic hydrocarbons from cigarette smoke. Urine samples from 30 people (15 smokers and 15 non-smokers) were sampled 6 hours after having consumed a beverage with a total caffeine content of 200 mg. A HPLC with UV detection method was used which allowed concomitant determination of the three analytes. The results obtained show different values of caffeine urine concentrations (6.47 ± 3.63 mM / L in smokers vs 10.09 ± 5.68 in non-smokers, p [0.05) and a higher elimination of N1-methyluric acid by over 50% in smokers (identifiable due to the presence of cotinine, the main metabolite of nicotine).
Keywords:
caffeine; cotinine; smoking; CYP1A2-mediated metabolism; sport monitoring

Issue: 2017, Volume 68, Issue 10
Pages: 2284-2288
Publication date: 2017/11/15
https://doi.org/10.37358/RC.17.10.5871
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Creative Commons License
This article is published under the Creative Commons Attribution 4.0 International License
Citation Styles
Cite this article as:
VESCAN, A.T., OSZ, B.E., MAIER, A., IMRE, S., ORMENISAN, A., HANCU, V., VARI, C.E., Concomitant Quantification of Caffeine, Cotinine and N-methyl Uric Acid in Urine. Applications for athlete monitoring and pharmacological screening, Rev. Chim., 68(10), 2017, 2284-2288.

Vancouver
Vescan AT, Osz BE, Maier A, Imre S, Ormenisan A, Hancu V, Vari CE. Concomitant Quantification of Caffeine, Cotinine and N-methyl Uric Acid in Urine. Applications for athlete monitoring and pharmacological screening. Rev. Chim.[internet]. 2017 Oct;68(10):2284-2288. Available from: https://doi.org/10.37358/RC.17.10.5871


APA 6th edition
Vescan, A.T., Osz, B.E., Maier, A., Imre, S., Ormenisan, A., Hancu, V. & Vari, C.E. (2017). Concomitant Quantification of Caffeine, Cotinine and N-methyl Uric Acid in Urine. Applications for athlete monitoring and pharmacological screening. Revista de Chimie, 68(10), 2284-2288. https://doi.org/10.37358/RC.17.10.5871


Harvard
Vescan, A.T., Osz, B.E., Maier, A., Imre, S., Ormenisan, A., Hancu, V., Vari, C.E. (2017). 'Concomitant Quantification of Caffeine, Cotinine and N-methyl Uric Acid in Urine. Applications for athlete monitoring and pharmacological screening', Revista de Chimie, 68(10), pp. 2284-2288. https://doi.org/10.37358/RC.17.10.5871


IEEE
A.T. Vescan, B.E. Osz, A. Maier, S. Imre, A. Ormenisan, V. Hancu, C.E. Vari, "Concomitant Quantification of Caffeine, Cotinine and N-methyl Uric Acid in Urine. Applications for athlete monitoring and pharmacological screening". Revista de Chimie, vol. 68, no. 10, pp. 2284-2288, 2017. [online]. https://doi.org/10.37358/RC.17.10.5871


Text
Amelia Tero Vescan, Bianca Eugenia Osz, Anca Maier, Silvia Imre, Alina Ormenisan, Violeta Hancu, Camil Eugen Vari,
Concomitant Quantification of Caffeine, Cotinine and N-methyl Uric Acid in Urine. Applications for athlete monitoring and pharmacological screening,
Revista de Chimie,
Volume 68, Issue 10,
2017,
Pages 2284-2288,
ISSN 2668-8212,
https://doi.org/10.37358/RC.17.10.5871.
(https://revistadechimie.ro/Articles.asp?ID=5871)
Keywords: caffeine; cotinine; smoking; CYP1A2-mediated metabolism; sport monitoring


RIS
TY - JOUR
T1 - Concomitant Quantification of Caffeine, Cotinine and N-methyl Uric Acid in Urine. Applications for athlete monitoring and pharmacological screening
A1 - Vescan, Amelia Tero
A2 - Osz, Bianca Eugenia
A3 - Maier, Anca
A4 - Imre, Silvia
A5 - Ormenisan, Alina
A6 - Hancu, Violeta
A7 - Vari, Camil Eugen
JF - Revista de Chimie
JO - Rev. Chim.
PB - Revista de Chimie SRL
SN - 2668-8212
Y1 - 2017
VL - 68
IS - 10
SP - 2284
EP - 2288
UR - https://doi.org/10.37358/RC.17.10.5871
KW - caffeine
KW - cotinine
KW - smoking
KW - CYP1A2-mediated metabolism
KW - sport monitoring
ER -


BibTex
@article{RevCh2017P2284,
author = {Vescan Amelia Tero and Osz Bianca Eugenia and Maier Anca and Imre Silvia and Ormenisan Alina and Hancu Violeta and Vari Camil Eugen},
title = {Concomitant Quantification of Caffeine, Cotinine and N-methyl Uric Acid in Urine. Applications for athlete monitoring and pharmacological screening},
journal = {Revista de Chimie},
volume = {68},
number = {10},
pages = {2284-2288},
year = {2017},
issn = {2668-8212},
doi = {https://doi.org/10.37358/RC.17.10.5871},
url = {https://revistadechimie.ro/Articles.asp?ID=5871}
}
 
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