MAGDALENA BIRSAN, NELA BIBIRE, MADALINA VIERIU, ALINA DIANA PANAINTE, ILEANA COJOCARU INFLUENCE OF HYDROXYPROPYL METHYLCELLULOSE ON FLOWING AND SWELLING PARAMETERS IN BIOMUCOADHESIVE TABLETS WITH MICONAZOLE NITRATE Original pharmaceutical formulations have been produced as oral biomucoadhesive tablets for antifungal medication. They have been obtained through direct compression using as matrix forming polymers various sorts of hydroxypropyl methylcellulose. The main goal of the study was determining the swelling index of the new mucobioadhesive formulations with miconazole nitrate in order to correctly evaluate the time of contact with mucosa, and the prolongation of drug release. For each formulation, the flowing parameters have been determined: flowing time, friction coefficient, repose angle, Haussner ratio, Carr index, and the swelling index for 6 formulations containing various sorts of hydroxypropyl methylcellulose as matrix molders, while the formulation variables studied were time and association ratio between those polymers. Though results analysis, we noticed that the values of the swelling index depended on the type and quantity of polymer, results that could also be explained by the proportionality relationship to flowing and compressibility parameters.