ABOUT INDEXING BOARD ARCHIVES AUTHOR GUIDELINES SUBMIT PAPER AUTHOR'S PAGE NEWS, EVENTS CONTACT
REVISTA DE CHIMIE
Cite as: Rev. Chim.
https://doi.org/10.37358/Rev.Chim.1949

OSIM Nr. R102355
ISSN Online 2668-8212
ISSN Print: 1582-9049
ISSN-L: 1582-9049

REVISTA DE CHIMIE Latest Issue

LATEST ISSUE >>>

   Volume 75, 2024
   Volume 74, 2023
   Volume 73, 2022
   Volume 72, 2021
   Volume 71, 2020
   Volume 70, 2019
   Volume 69, 2018
   Volume 68, 2017
   Volume 67, 2016
   Volume 66, 2015
   Volume 65, 2014
   Volume 64, 2013
   Volume 63, 2012
   Volume 62, 2011
   Volume 61, 2010
   Volume 60, 2009
   Volume 59, 2008
   Volume 58, 2007
 
<<<< back

Revista de Chimie (Rev. Chim.), Year 2017, Volume 68, Issue 10, 2346-2349

https://doi.org/10.37358/RC.17.10.5883

Magdalena Birsan, Nela Bibire, Madalina Vieriu, Alina Diana Panainte, Ileana Cojocaru

Influence of Hydroxypropyl Methylcellulose on Flowing and Swelling Parameters in Biomucoadhesive Tablets with Miconazole Nitrate

Abstract:

Original pharmaceutical formulations have been produced as oral biomucoadhesive tablets for antifungal medication. They have been obtained through direct compression using as matrix forming polymers various sorts of hydroxypropyl methylcellulose. The main goal of the study was determining the swelling index of the new mucobioadhesive formulations with miconazole nitrate in order to correctly evaluate the time of contact with mucosa, and the prolongation of drug release. For each formulation, the flowing parameters have been determined: flowing time, friction coefficient, repose angle, Haussner ratio, Carr index, and the swelling index for 6 formulations containing various sorts of hydroxypropyl methylcellulose as matrix molders, while the formulation variables studied were time and association ratio between those polymers. Though results analysis, we noticed that the values of the swelling index depended on the type and quantity of polymer, results that could also be explained by the proportionality relationship to flowing and compressibility parameters.
Keywords:
hydroxypropyl methylcellulose; swelling index; mucobioadhesive tablets; miconazole nitrate

Issue: 2017, Volume 68, Issue 10
Pages: 2346-2349
Publication date: 2017/11/15
https://doi.org/10.37358/RC.17.10.5883
download pdf   Download Pdf Article
Creative Commons License
This article is published under the Creative Commons Attribution 4.0 International License
Citation Styles
Cite this article as:
BIRSAN, M., BIBIRE, N., VIERIU, M., PANAINTE, A.D., COJOCARU, I., Influence of Hydroxypropyl Methylcellulose on Flowing and Swelling Parameters in Biomucoadhesive Tablets with Miconazole Nitrate, Rev. Chim., 68(10), 2017, 2346-2349.

Vancouver
Birsan M, Bibire N, Vieriu M, Panainte AD, Cojocaru I. Influence of Hydroxypropyl Methylcellulose on Flowing and Swelling Parameters in Biomucoadhesive Tablets with Miconazole Nitrate. Rev. Chim.[internet]. 2017 Oct;68(10):2346-2349. Available from: https://doi.org/10.37358/RC.17.10.5883


APA 6th edition
Birsan, M., Bibire, N., Vieriu, M., Panainte, A.D. & Cojocaru, I. (2017). Influence of Hydroxypropyl Methylcellulose on Flowing and Swelling Parameters in Biomucoadhesive Tablets with Miconazole Nitrate. Revista de Chimie, 68(10), 2346-2349. https://doi.org/10.37358/RC.17.10.5883


Harvard
Birsan, M., Bibire, N., Vieriu, M., Panainte, A.D., Cojocaru, I. (2017). 'Influence of Hydroxypropyl Methylcellulose on Flowing and Swelling Parameters in Biomucoadhesive Tablets with Miconazole Nitrate', Revista de Chimie, 68(10), pp. 2346-2349. https://doi.org/10.37358/RC.17.10.5883


IEEE
M. Birsan, N. Bibire, M. Vieriu, A.D. Panainte, I. Cojocaru, "Influence of Hydroxypropyl Methylcellulose on Flowing and Swelling Parameters in Biomucoadhesive Tablets with Miconazole Nitrate". Revista de Chimie, vol. 68, no. 10, pp. 2346-2349, 2017. [online]. https://doi.org/10.37358/RC.17.10.5883


Text
Magdalena Birsan, Nela Bibire, Madalina Vieriu, Alina Diana Panainte, Ileana Cojocaru,
Influence of Hydroxypropyl Methylcellulose on Flowing and Swelling Parameters in Biomucoadhesive Tablets with Miconazole Nitrate,
Revista de Chimie,
Volume 68, Issue 10,
2017,
Pages 2346-2349,
ISSN 2668-8212,
https://doi.org/10.37358/RC.17.10.5883.
(https://revistadechimie.ro/Articles.asp?ID=5883)
Keywords: hydroxypropyl methylcellulose; swelling index; mucobioadhesive tablets; miconazole nitrate


RIS
TY - JOUR
T1 - Influence of Hydroxypropyl Methylcellulose on Flowing and Swelling Parameters in Biomucoadhesive Tablets with Miconazole Nitrate
A1 - Birsan, Magdalena
A2 - Bibire, Nela
A3 - Vieriu, Madalina
A4 - Panainte, Alina Diana
A5 - Cojocaru, Ileana
JF - Revista de Chimie
JO - Rev. Chim.
PB - Revista de Chimie SRL
SN - 2668-8212
Y1 - 2017
VL - 68
IS - 10
SP - 2346
EP - 2349
UR - https://doi.org/10.37358/RC.17.10.5883
KW - hydroxypropyl methylcellulose
KW - swelling index
KW - mucobioadhesive tablets
KW - miconazole nitrate
ER -


BibTex
@article{RevCh2017P2346,
author = {Birsan Magdalena and Bibire Nela and Vieriu Madalina and Panainte Alina Diana and Cojocaru Ileana},
title = {Influence of Hydroxypropyl Methylcellulose on Flowing and Swelling Parameters in Biomucoadhesive Tablets with Miconazole Nitrate},
journal = {Revista de Chimie},
volume = {68},
number = {10},
pages = {2346-2349},
year = {2017},
issn = {2668-8212},
doi = {https://doi.org/10.37358/RC.17.10.5883},
url = {https://revistadechimie.ro/Articles.asp?ID=5883}
}
 
<<<< back
 
PUBLISHING SECTION
Author Guidelines
 * Paper Drafting
 * Paper Template
 * Ethical Statement
 * Paper Submission
Ghidul Autorului (ro)
Submit Paper
Author's Page
Publishing Ethics
Peer Review Process
Open Access & Archiving Policy
 Search Authors
 LATEST NEWS
REvista de Chimie NUMAR OMAGIAL PETRU PONI.. detalii
REvista de Chimie Revista de Chimie - 70 de ani de aparitie neintrerupta.. detalii
dictionar English-Romanian Dictionary for Mechanical Engineering
(download pdf)
  News, Events
Crossref Member Badge
 DOI  logo
 Gold Open Access | Source=http://www.plos.org/  | Author=art designer at PLoS
Creative Commons License
 Conferences of Contemporary
 Chemistry
 Biblioteca Chimiei
 Materiale Plastice