ANCA MUNTEANU, ALEXANDRU PATRASCU, DAN FERARIU THE IMPORTANCE OF IMMUNOHISTOCHEMISTRY TECHNIQUES IN ASSESSING THE PROGNOSIS OF MULTIMODALLY TREATED BREAST CANCER The identification of prognostic factors in the invasive breast cancer is particularly important for the therapeutic approach appropriate to the aggression of neoplasia. Determining the impact of multiple prognostic factors and correlating clinical and immunohistochemical factors allow the treatment to be adjusted so as to avoid the over-treatment of less aggressive neoplasms and to select the optimal multimodal neoadjuvant and adjuvant treatment in cancers with increased aggressiveness. Tissue samples obtained by breast tumor biopsy were studied by classical histopathology methods and by immunohistochemistry techniques, followed by the determination of the histological type, degree of tumor differentiation, status of estrogenic and progesterone receptors, Her2 status. Subsequently, the analysis of the particularities of the prognostic factors associated with the cases with aggressive, metastatic evolution was performed.
Key words: breast cancer, immunohistochemistry, chemotherapy, radiotherapy