MUHAMMAD LIAQAT, TARIQ MAHMUD, MUHAMMAD ASHRAF, MUHAMMAD MUDDASSAR, MUHAMMAD IMRAN, TAUQEER AHMAD, LIVIU MITU SYNTHESIS, CHARACTERIZATION AND BIOLOGICAL ACTIVITIES OF A NOVEL MANNICH BASE 2-<(3,4-DIMETHOXYPHENYL)(PYRROLIDINYL) METHYL>CYCLOHEXANONE AND ITS COMPLEXES WITH CU(II), NI(II), CO(II) AND FE(II) IONS The titled Mannich base 2-<(3,4-dimethoxyphenyl)(pyrrolidin-1-yl)methyl>cyclohexanone (DPC) was synthesized by condensing 3,4-dimethoxybenzaldehyde, pyrrolidine and cyclohexanone. The synthesis was carried out by using ethanol as solvent. The development of the reaction was monitored on TLC. The complexation of synthesized Mannich base was carried out with Cu(II) chloride, Co(II) chloride, Ni(II) chloride and Fe(II) chloride. The structures of the synthesized Mannich base and its complexes were confirmed by FT-IR, UV-Vis, 1H-NMR, 13C-NMR, MS and TGA techniques. The proposed geometries of the metal complexes were established on the basis of metal/ligand ratio through AAS/ICP and electronic spectra. The synthesized compounds were evaluated for their antiurease and antibacterial activities. The complex with Co(II) show potent antiurease and antibacterial activity. The nature of SAR of Co(II) has been demonstrated using docking studies.
Keywords: Metal complexes, antiurease, antibacterial activity