Synthesis, Characterization and Biological Activities of a Novel Mannich Base 2-<(3,4-dimethoxyphenyl)(pyrrolidinyl) methyl>cyclohexanone and its Complexes with Cu(II), Ni(II), Co(II) and Fe(II) Ions

Liaqat, Muhammad; Mahmud, Tariq; Ashraf, Muhammad; Muddassar, Muhammad; Imran, Muhammad; Ahmad, Tauqeer; Mitu, Liviu

Muhammad Liaqat, Tariq Mahmud, Muhammad Ashraf, Muhammad Muddassar, Muhammad Imran, Tauqeer Ahmad, Liviu Mitu

Synthesis, Characterization and Biological Activities of a Novel Mannich Base 2-<(3,4-dimethoxyphenyl)(pyrrolidinyl) methyl>cyclohexanone and its Complexes with Cu(II), Ni(II), Co(II) and Fe(II) Ions

Abstract:

The titled Mannich base 2-[(3,4-dimethoxyphenyl)(pyrrolidin-1-yl)methyl]cyclohexanone (DPC) was synthesized by condensing 3,4-dimethoxybenzaldehyde, pyrrolidine and cyclohexanone. The synthesis was carried out by using ethanol as solvent. The development of the reaction was monitored on TLC. The complexation of synthesized Mannich base was carried out with Cu(II) chloride, Co(II) chloride, Ni(II) chloride and Fe(II) chloride. The structures of the synthesized Mannich base and its complexes were confirmed by FT-IR, UV-Vis, 1H-NMR, 13C-NMR, MS and TGA techniques. The proposed geometries of the metal complexes were established on the basis of metal/ligand ratio through AAS/ICP and electronic spectra. The synthesized compounds were evaluated for their antiurease and antibacterial activities. The complex with Co(II) show potent antiurease and antibacterial activity. The nature of SAR of Co(II) has been demonstrated using docking studies.

Keywords:
Metal complexes; antiurease; antibacterial activity

Issue: 2017, Volume 68, Issue 12

Pages: 2845-2849

Publication date: 2018/1/15

https://doi.org/10.37358/RC.17.12.5991

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This article is published under the Creative Commons Attribution 4.0 International License

Citation Styles

Cite this article as:
LIAQAT, M., MAHMUD, T., ASHRAF, M., MUDDASSAR, M., IMRAN, M., AHMAD, T., MITU, L., Synthesis, Characterization and Biological Activities of a Novel Mannich Base 2-<(3,4-dimethoxyphenyl)(pyrrolidinyl) methyl>cyclohexanone and its Complexes with Cu(II), Ni(II), Co(II) and Fe(II) Ions, Rev. Chim., 68(12), 2017, 2845-2849.

Vancouver
Liaqat M, Mahmud T, Ashraf M, Muddassar M, Imran M, Ahmad T, Mitu L. Synthesis, Characterization and Biological Activities of a Novel Mannich Base 2-<(3,4-dimethoxyphenyl)(pyrrolidinyl) methyl>cyclohexanone and its Complexes with Cu(II), Ni(II), Co(II) and Fe(II) Ions. Rev. Chim.[internet]. 2017 Dec;68(12):2845-2849. Available from: https://doi.org/10.37358/RC.17.12.5991

APA 6th edition
Liaqat, M., Mahmud, T., Ashraf, M., Muddassar, M., Imran, M., Ahmad, T. & Mitu, L. (2017). Synthesis, Characterization and Biological Activities of a Novel Mannich Base 2-<(3,4-dimethoxyphenyl)(pyrrolidinyl) methyl>cyclohexanone and its Complexes with Cu(II), Ni(II), Co(II) and Fe(II) Ions. Revista de Chimie, 68(12), 2845-2849. https://doi.org/10.37358/RC.17.12.5991

Harvard
Liaqat, M., Mahmud, T., Ashraf, M., Muddassar, M., Imran, M., Ahmad, T., Mitu, L. (2017). 'Synthesis, Characterization and Biological Activities of a Novel Mannich Base 2-<(3,4-dimethoxyphenyl)(pyrrolidinyl) methyl>cyclohexanone and its Complexes with Cu(II), Ni(II), Co(II) and Fe(II) Ions', Revista de Chimie, 68(12), pp. 2845-2849. https://doi.org/10.37358/RC.17.12.5991

IEEE
M. Liaqat, T. Mahmud, M. Ashraf, M. Muddassar, M. Imran, T. Ahmad, L. Mitu, "Synthesis, Characterization and Biological Activities of a Novel Mannich Base 2-<(3,4-dimethoxyphenyl)(pyrrolidinyl) methyl>cyclohexanone and its Complexes with Cu(II), Ni(II), Co(II) and Fe(II) Ions". Revista de Chimie, vol. 68, no. 12, pp. 2845-2849, 2017. [online]. https://doi.org/10.37358/RC.17.12.5991

Text
Muhammad Liaqat, Tariq Mahmud, Muhammad Ashraf, Muhammad Muddassar, Muhammad Imran, Tauqeer Ahmad, Liviu Mitu,
Synthesis, Characterization and Biological Activities of a Novel Mannich Base 2-<(3,4-dimethoxyphenyl)(pyrrolidinyl) methyl>cyclohexanone and its Complexes with Cu(II), Ni(II), Co(II) and Fe(II) Ions,
Revista de Chimie,
Volume 68, Issue 12,
2017,
Pages 2845-2849,
ISSN 2668-8212,
https://doi.org/10.37358/RC.17.12.5991.
(https://revistadechimie.ro/Articles.asp?ID=5991)
Keywords: Metal complexes; antiurease; antibacterial activity

RIS
TY - JOUR
T1 - Synthesis, Characterization and Biological Activities of a Novel Mannich Base 2-<(3,4-dimethoxyphenyl)(pyrrolidinyl) methyl>cyclohexanone and its Complexes with Cu(II), Ni(II), Co(II) and Fe(II) Ions
A1 - Liaqat, Muhammad
A2 - Mahmud, Tariq
A3 - Ashraf, Muhammad
A4 - Muddassar, Muhammad
A5 - Imran, Muhammad
A6 - Ahmad, Tauqeer
A7 - Mitu, Liviu
JF - Revista de Chimie
JO - Rev. Chim.
PB - Revista de Chimie SRL
SN - 2668-8212
Y1 - 2017
VL - 68
IS - 12
SP - 2845
EP - 2849
UR - https://doi.org/10.37358/RC.17.12.5991
KW - Metal complexes
KW - antiurease
KW - antibacterial activity
ER -

BibTex
@article{RevCh2017P2845,
author = {Liaqat Muhammad and Mahmud Tariq and Ashraf Muhammad and Muddassar Muhammad and Imran Muhammad and Ahmad Tauqeer and Mitu Liviu},
title = {Synthesis, Characterization and Biological Activities of a Novel Mannich Base 2-<(3,4-dimethoxyphenyl)(pyrrolidinyl) methyl>cyclohexanone and its Complexes with Cu(II), Ni(II), Co(II) and Fe(II) Ions},
journal = {Revista de Chimie},
volume = {68},
number = {12},
pages = {2845-2849},
year = {2017},
issn = {2668-8212},
doi = {https://doi.org/10.37358/RC.17.12.5991},
url = {https://revistadechimie.ro/Articles.asp?ID=5991}
}

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