The Role of Low Molecular Weight Heparin in Pregnancies of Patients with Inherited Thrombophilia that Have Presented (and) Thrombotic Complications During Previous Pregnancies

Mitranovici, Melinda Ildiko; Puscasiu, Lucian; Craina, Marius; Iacob, Daniela; Chiriac, Veronica Daniela; Ionita, Ioana; Moleriu, Radu Dumitru; Furau, Gheorghe; Sisu, Alina; Petre, Izabella

Melinda Ildiko Mitranovici, Lucian Puscasiu, Marius Craina, Daniela Iacob, Veronica Daniela Chiriac, Ioana Ionita, Radu Dumitru Moleriu, Gheorghe Furau, Alina Sisu, Izabella Petre

The Role of Low Molecular Weight Heparin in Pregnancies of Patients with Inherited Thrombophilia that Have Presented (and) Thrombotic Complications During Previous Pregnancies

Abstract:

What is presently known is that thromboembolic disease represents a major cause of morbidity and mortality during pregnancy. To this we add a rare but not negligible pathology, acquired and inherited thrombophilia, which increases the predisposition for thrombotic events during pregnancy. In this article, what has been studied is the impact that LMWH has on patients with inherited thrombophilia, both the conventional FV, FII and the newly introduced MTHFR, PAI, FXII, factors which are often combined.81 patients have been taken into consideration / included in study, with the following anterior results, before the patients discovered their illnesses, thus before following treatment: first trimester or advanced pregnancy loss, IUGR, premature birth or secondary placental thrombotic complications such as: preeclampsia, DPPNI or dead fetuses, as well as maternal thrombotic accidents. The administration of LMWH decreased the rate of pregnancy loss compared to untreated pregnancies is statistical significant (p= 0.004), there were fewer DPPNI (p= 0.006), and no intrauterine deaths. We also compared the occurrence of thrombotic events during treated and untreated pregnancies and we observed significant differences in this groups (p= 0.001). There was also a sufficient number of patients with new types of thrombophilia included in the study to demonstrate the impact it has on pregnancy. LMWH improves the situation of women with thrombophilia during pregnancy.

Keywords:
Inherited thrombophilia; LMWH; pregnancy complications

Issue: 2017, Volume 68, Issue 12

Pages: 2970-2973

Publication date: 2018/1/15

https://doi.org/10.37358/RC.17.12.6019

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This article is published under the Creative Commons Attribution 4.0 International License

Citation Styles

Cite this article as:
MITRANOVICI, M.I., PUSCASIU, L., CRAINA, M., IACOB, D., CHIRIAC, V.D., IONITA, I., MOLERIU, R.D., FURAU, G., SISU, A., PETRE, I., The Role of Low Molecular Weight Heparin in Pregnancies of Patients with Inherited Thrombophilia that Have Presented (and) Thrombotic Complications During Previous Pregnancies, Rev. Chim., 68(12), 2017, 2970-2973.

Vancouver
Mitranovici MI, Puscasiu L, Craina M, Iacob D, Chiriac VD, Ionita I, Moleriu RD, Furau G, Sisu A, Petre I. The Role of Low Molecular Weight Heparin in Pregnancies of Patients with Inherited Thrombophilia that Have Presented (and) Thrombotic Complications During Previous Pregnancies. Rev. Chim.[internet]. 2017 Dec;68(12):2970-2973. Available from: https://doi.org/10.37358/RC.17.12.6019

APA 6th edition
Mitranovici, M.I., Puscasiu, L., Craina, M., Iacob, D., Chiriac, V.D., Ionita, I.,... Petre, I. (2017). The Role of Low Molecular Weight Heparin in Pregnancies of Patients with Inherited Thrombophilia that Have Presented (and) Thrombotic Complications During Previous Pregnancies. Revista de Chimie, 68(12), 2970-2973. https://doi.org/10.37358/RC.17.12.6019

Harvard
Mitranovici, M.I., Puscasiu, L., Craina, M., Iacob, D., Chiriac, V.D., Ionita, I., Moleriu, R.D., Furau, G., Sisu, A., Petre, I. (2017). 'The Role of Low Molecular Weight Heparin in Pregnancies of Patients with Inherited Thrombophilia that Have Presented (and) Thrombotic Complications During Previous Pregnancies', Revista de Chimie, 68(12), pp. 2970-2973. https://doi.org/10.37358/RC.17.12.6019

IEEE
M.I. Mitranovici, L. Puscasiu, M. Craina, D. Iacob, V.D. Chiriac, I. Ionita, R.D. Moleriu, G. Furau, A. Sisu, I. Petre, "The Role of Low Molecular Weight Heparin in Pregnancies of Patients with Inherited Thrombophilia that Have Presented (and) Thrombotic Complications During Previous Pregnancies". Revista de Chimie, vol. 68, no. 12, pp. 2970-2973, 2017. [online]. https://doi.org/10.37358/RC.17.12.6019

Text
Melinda Ildiko Mitranovici, Lucian Puscasiu, Marius Craina, Daniela Iacob, Veronica Daniela Chiriac, Ioana Ionita, Radu Dumitru Moleriu, Gheorghe Furau, Alina Sisu, Izabella Petre,
The Role of Low Molecular Weight Heparin in Pregnancies of Patients with Inherited Thrombophilia that Have Presented (and) Thrombotic Complications During Previous Pregnancies,
Revista de Chimie,
Volume 68, Issue 12,
2017,
Pages 2970-2973,
ISSN 2668-8212,
https://doi.org/10.37358/RC.17.12.6019.
(https://revistadechimie.ro/Articles.asp?ID=6019)
Keywords: Inherited thrombophilia; LMWH; pregnancy complications

RIS
TY - JOUR
T1 - The Role of Low Molecular Weight Heparin in Pregnancies of Patients with Inherited Thrombophilia that Have Presented (and) Thrombotic Complications During Previous Pregnancies
A1 - Mitranovici, Melinda Ildiko
A2 - Puscasiu, Lucian
A3 - Craina, Marius
A4 - Iacob, Daniela
A5 - Chiriac, Veronica Daniela
A6 - Ionita, Ioana
A7 - Moleriu, Radu Dumitru
A8 - Furau, Gheorghe
A9 - Sisu, Alina
A10 - Petre, Izabella
JF - Revista de Chimie
JO - Rev. Chim.
PB - Revista de Chimie SRL
SN - 2668-8212
Y1 - 2017
VL - 68
IS - 12
SP - 2970
EP - 2973
UR - https://doi.org/10.37358/RC.17.12.6019
KW - Inherited thrombophilia
KW - LMWH
KW - pregnancy complications
ER -

BibTex
@article{RevCh2017P2970,
author = {Mitranovici Melinda Ildiko and Puscasiu Lucian and Craina Marius and Iacob Daniela and Chiriac Veronica Daniela and Ionita Ioana and Moleriu Radu Dumitru and Furau Gheorghe and Sisu Alina and Petre Izabella},
title = {The Role of Low Molecular Weight Heparin in Pregnancies of Patients with Inherited Thrombophilia that Have Presented (and) Thrombotic Complications During Previous Pregnancies},
journal = {Revista de Chimie},
volume = {68},
number = {12},
pages = {2970-2973},
year = {2017},
issn = {2668-8212},
doi = {https://doi.org/10.37358/RC.17.12.6019},
url = {https://revistadechimie.ro/Articles.asp?ID=6019}
}

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