ABOUT INDEXING BOARD ARCHIVES AUTHOR GUIDELINES SUBMIT PAPER AUTHOR'S PAGE NEWS, EVENTS CONTACT
REVISTA DE CHIMIE
Cite as: Rev. Chim.
https://doi.org/10.37358/Rev.Chim.1949

OSIM Nr. R102355
ISSN Online 2668-8212
ISSN Print: 1582-9049
ISSN-L: 1582-9049

REVISTA DE CHIMIE Latest Issue

LATEST ISSUE >>>

   Volume 75, 2024
   Volume 74, 2023
   Volume 73, 2022
   Volume 72, 2021
   Volume 71, 2020
   Volume 70, 2019
   Volume 69, 2018
   Volume 68, 2017
   Volume 67, 2016
   Volume 66, 2015
   Volume 65, 2014
   Volume 64, 2013
   Volume 63, 2012
   Volume 62, 2011
   Volume 61, 2010
   Volume 60, 2009
   Volume 59, 2008
   Volume 58, 2007
 
<<<< back

Revista de Chimie (Rev. Chim.), Year 2017, Volume 68, Issue 12, 2978-2983

https://doi.org/10.37358/RC.17.12.6021

Tiberiu Paul Neagu, Ion Cocolos, Cristian Cobilinschi, Mirela Tiglis, Ioan Petre Florescu, Elisabeta Badila, Ruxandra Diana Sinescu

The Benefits of Botulinum Neurotoxin Treatment in a Multitude of Medical Conditions

Abstract:

Botulinum neurotoxins (BoNTs) are responsible for botulism in humans and vertebrates, being one of the six most catastrophic potential bioterrorism agents. This are ~150 kDa proteins, assembled as a ~50 kDa light chain (LC) and a ~100 kDa heavy chain (HC). The LC acts like a zinc metalloproteinase that cleaves three proteins in neurons, members of the SNARE (Soluble N-ethylmaleimide sensitive fusion attachment protein receptors) family: VAMP (vesicle-associated membrane protein) / synaptobrevin, SNAP-25 (synaptosomal-associated protein 25) and syntaxin. After cleavage of any of this proteins, neurotransmission is blocked and flaccid paralysis of the muscle is installed. This extraordinary restricted tropism for the cholinergic presynaptic membrane makes this drug unique regarding its toxicity, pharmacological and therapeutic use. Taking into consideration the potential of this substance, this paper aims to summarize the most relevant data regarding the mechanism of actions and its main clinical applications, in order to improve medical practice. Therefore, we presented the mechanism of action in order to understand its usage in different pathologies, such as dystonias, spasticity, nephrologic and urologic conditions, cosmetic use, depression, gastroenterologic and proctologic diseases, dermatologic conditions, pathologies specific to plastic surgery and also the role of BoNT therapy in pain management. It is well documented in the literature that important discoveries have been made through recent experimental and clinical studies. Even so, there is still much to learn about the therapeutic action of this drug in terms of molecular and pathophysiological mechanisms, in order to benefit of the whole healing potential of this amazing toxin.
Keywords:
botulinum toxin; movement disorders; pain management; neurotransmission blockage; zinc metalloproteinase

Issue: 2017, Volume 68, Issue 12
Pages: 2978-2983
Publication date: 2018/1/15
https://doi.org/10.37358/RC.17.12.6021
download pdf   Download Pdf Article
Creative Commons License
This article is published under the Creative Commons Attribution 4.0 International License
Citation Styles
Cite this article as:
NEAGU, T.P., COCOLOS, I., COBILINSCHI, C., TIGLIS, M., FLORESCU, I.P., BADILA, E., SINESCU, R.D., The Benefits of Botulinum Neurotoxin Treatment in a Multitude of Medical Conditions, Rev. Chim., 68(12), 2017, 2978-2983.

Vancouver
Neagu TP, Cocolos I, Cobilinschi C, Tiglis M, Florescu IP, Badila E, Sinescu RD. The Benefits of Botulinum Neurotoxin Treatment in a Multitude of Medical Conditions. Rev. Chim.[internet]. 2017 Dec;68(12):2978-2983. Available from: https://doi.org/10.37358/RC.17.12.6021


APA 6th edition
Neagu, T.P., Cocolos, I., Cobilinschi, C., Tiglis, M., Florescu, I.P., Badila, E. & Sinescu, R.D. (2017). The Benefits of Botulinum Neurotoxin Treatment in a Multitude of Medical Conditions. Revista de Chimie, 68(12), 2978-2983. https://doi.org/10.37358/RC.17.12.6021


Harvard
Neagu, T.P., Cocolos, I., Cobilinschi, C., Tiglis, M., Florescu, I.P., Badila, E., Sinescu, R.D. (2017). 'The Benefits of Botulinum Neurotoxin Treatment in a Multitude of Medical Conditions', Revista de Chimie, 68(12), pp. 2978-2983. https://doi.org/10.37358/RC.17.12.6021


IEEE
T.P. Neagu, I. Cocolos, C. Cobilinschi, M. Tiglis, I.P. Florescu, E. Badila, R.D. Sinescu, "The Benefits of Botulinum Neurotoxin Treatment in a Multitude of Medical Conditions". Revista de Chimie, vol. 68, no. 12, pp. 2978-2983, 2017. [online]. https://doi.org/10.37358/RC.17.12.6021


Text
Tiberiu Paul Neagu, Ion Cocolos, Cristian Cobilinschi, Mirela Tiglis, Ioan Petre Florescu, Elisabeta Badila, Ruxandra Diana Sinescu,
The Benefits of Botulinum Neurotoxin Treatment in a Multitude of Medical Conditions,
Revista de Chimie,
Volume 68, Issue 12,
2017,
Pages 2978-2983,
ISSN 2668-8212,
https://doi.org/10.37358/RC.17.12.6021.
(https://revistadechimie.ro/Articles.asp?ID=6021)
Keywords: botulinum toxin; movement disorders; pain management; neurotransmission blockage; zinc metalloproteinase


RIS
TY - JOUR
T1 - The Benefits of Botulinum Neurotoxin Treatment in a Multitude of Medical Conditions
A1 - Neagu, Tiberiu Paul
A2 - Cocolos, Ion
A3 - Cobilinschi, Cristian
A4 - Tiglis, Mirela
A5 - Florescu, Ioan Petre
A6 - Badila, Elisabeta
A7 - Sinescu, Ruxandra Diana
JF - Revista de Chimie
JO - Rev. Chim.
PB - Revista de Chimie SRL
SN - 2668-8212
Y1 - 2017
VL - 68
IS - 12
SP - 2978
EP - 2983
UR - https://doi.org/10.37358/RC.17.12.6021
KW - botulinum toxin
KW - movement disorders
KW - pain management
KW - neurotransmission blockage
KW - zinc metalloproteinase
ER -


BibTex
@article{RevCh2017P2978,
author = {Neagu Tiberiu Paul and Cocolos Ion and Cobilinschi Cristian and Tiglis Mirela and Florescu Ioan Petre and Badila Elisabeta and Sinescu Ruxandra Diana},
title = {The Benefits of Botulinum Neurotoxin Treatment in a Multitude of Medical Conditions},
journal = {Revista de Chimie},
volume = {68},
number = {12},
pages = {2978-2983},
year = {2017},
issn = {2668-8212},
doi = {https://doi.org/10.37358/RC.17.12.6021},
url = {https://revistadechimie.ro/Articles.asp?ID=6021}
}
 
<<<< back
 
PUBLISHING SECTION
Author Guidelines
 * Paper Drafting
 * Paper Template
 * Ethical Statement
 * Paper Submission
Ghidul Autorului (ro)
Submit Paper
Author's Page
Publishing Ethics
Peer Review Process
Open Access & Archiving Policy
 Search Authors
 LATEST NEWS
REvista de Chimie NUMAR OMAGIAL PETRU PONI.. detalii
REvista de Chimie Revista de Chimie - 70 de ani de aparitie neintrerupta.. detalii
dictionar English-Romanian Dictionary for Mechanical Engineering
(download pdf)
  News, Events
Crossref Member Badge
 DOI  logo
 Gold Open Access | Source=http://www.plos.org/  | Author=art designer at PLoS
Creative Commons License
 Conferences of Contemporary
 Chemistry
 Biblioteca Chimiei
 Materiale Plastice