Metabolic Abnormalities and Spectroscopy Biochemical Cerebral Compounds Modifications in Children and Adolescents with Antipsychotic Treatment

Talpos, Cristina; Ageu, Luminita; Crisan, Simina; Zamfir, Carmen Lacramioara; Poroch, Vladimir; Anghel, Mirela

Cristina Talpos, Luminita Ageu, Simina Crisan, Carmen Lacramioara Zamfir, Vladimir Poroch, Mirela Anghel

Metabolic Abnormalities and Spectroscopy Biochemical Cerebral Compounds Modifications in Children and Adolescents with Antipsychotic Treatment

Abstract:

We approach an integrated, multidisciplinary, innovative research-action model in children and adolescents with psychosis. Our main focus was: to investigate the biochemical cerebral compounds and metabolites (NAA-N-acetylaspartate, GABA-Gama-Aminobutyric Acid, Asp-Aspartate, CR-Creatine, Gln-Glutamine, GPC-Glicerophosphocholine, PC-Phosphocholine, PCr-Phosphocreatine, Tau-Taurine, N-MDA-N-Metyl-D-Aspartate, Serine, Glicine, Cho-Choline); the neuroimagistic and neurobiological markers and the metabolic abnormalities in correlation with the molecular pharmacogenetic testing in psychoses, treated with antipsychotic medication; the dynamic evaluation of the clinical evolution for the studied groups in correlation with specific biochemical, metabolic, neurobiological and neuroimagistic variables and markers. Our research was conducted in the period 2010-2016 on 85 patients, children and adolescents with psychosis (42 took treatment after pharmacogenetic testing, 43 without). Also, the patients were evaluated through magnetic resonance (MR) spectroscopy at baseline and after pharmacotherapy. The efficacy of the chosen therapy in correlation with the pharmacogenetic testing was evaluated through the mean change in the Positive and Negative Syndrome Scale (PANSS) total scores, in the Clinical Global Impression Severity (CGI-S/I), Clinical Global Assessment of Functioning (CGAS) and through the change registered for the relevant biochemical, metabolic, neurobiological markers and MR spectroscopy metabolites, from baseline till endpoint in different timepoints. Our results, showed statistically significant differences of the clinical scores between the studied groups. Our research was a proof, that the biochemical brain metabolites register in psychoses modified values in the MR Spectroscopy, the administration of antipsychotics can determine metabolic abnormalities (changed lipid profiles, high insulin and blood sugar levels, weight gain, obesity). But on the other side, if the antipsychotic treatment is chosen properly according to the pharmacogenetic profile of the patient, then the biochemical metabolites obtained through the MR Spectroscopy, register improvement of the values correlated with the good clinical evolution.

Keywords:
biochemical metabolites; metabolic abnormalities; antipsychotics; NAA-N-acetylaspartate; GABA-Gama-Aminobutyric Acid; N-MDA

Issue: 2017, Volume 68, Issue 12

Pages: 3022-3026

Publication date: 2018/1/15

https://doi.org/10.37358/RC.17.12.6030

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Citation Styles

Cite this article as:
TALPOS, C., AGEU, L., CRISAN, S., ZAMFIR, C.L., POROCH, V., ANGHEL, M., Metabolic Abnormalities and Spectroscopy Biochemical Cerebral Compounds Modifications in Children and Adolescents with Antipsychotic Treatment, Rev. Chim., 68(12), 2017, 3022-3026.

Vancouver
Talpos C, Ageu L, Crisan S, Zamfir CL, Poroch V, Anghel M. Metabolic Abnormalities and Spectroscopy Biochemical Cerebral Compounds Modifications in Children and Adolescents with Antipsychotic Treatment. Rev. Chim.[internet]. 2017 Dec;68(12):3022-3026. Available from: https://doi.org/10.37358/RC.17.12.6030

APA 6th edition
Talpos, C., Ageu, L., Crisan, S., Zamfir, C.L., Poroch, V. & Anghel, M. (2017). Metabolic Abnormalities and Spectroscopy Biochemical Cerebral Compounds Modifications in Children and Adolescents with Antipsychotic Treatment. Revista de Chimie, 68(12), 3022-3026. https://doi.org/10.37358/RC.17.12.6030

Harvard
Talpos, C., Ageu, L., Crisan, S., Zamfir, C.L., Poroch, V., Anghel, M. (2017). 'Metabolic Abnormalities and Spectroscopy Biochemical Cerebral Compounds Modifications in Children and Adolescents with Antipsychotic Treatment', Revista de Chimie, 68(12), pp. 3022-3026. https://doi.org/10.37358/RC.17.12.6030

IEEE
C. Talpos, L. Ageu, S. Crisan, C.L. Zamfir, V. Poroch, M. Anghel, "Metabolic Abnormalities and Spectroscopy Biochemical Cerebral Compounds Modifications in Children and Adolescents with Antipsychotic Treatment". Revista de Chimie, vol. 68, no. 12, pp. 3022-3026, 2017. [online]. https://doi.org/10.37358/RC.17.12.6030

Text
Cristina Talpos, Luminita Ageu, Simina Crisan, Carmen Lacramioara Zamfir, Vladimir Poroch, Mirela Anghel,
Metabolic Abnormalities and Spectroscopy Biochemical Cerebral Compounds Modifications in Children and Adolescents with Antipsychotic Treatment,
Revista de Chimie,
Volume 68, Issue 12,
2017,
Pages 3022-3026,
ISSN 2668-8212,
https://doi.org/10.37358/RC.17.12.6030.
(https://revistadechimie.ro/Articles.asp?ID=6030)
Keywords: biochemical metabolites; metabolic abnormalities; antipsychotics; NAA-N-acetylaspartate; GABA-Gama-Aminobutyric Acid; N-MDA

RIS
TY - JOUR
T1 - Metabolic Abnormalities and Spectroscopy Biochemical Cerebral Compounds Modifications in Children and Adolescents with Antipsychotic Treatment
A1 - Talpos, Cristina
A2 - Ageu, Luminita
A3 - Crisan, Simina
A4 - Zamfir, Carmen Lacramioara
A5 - Poroch, Vladimir
A6 - Anghel, Mirela
JF - Revista de Chimie
JO - Rev. Chim.
PB - Revista de Chimie SRL
SN - 2668-8212
Y1 - 2017
VL - 68
IS - 12
SP - 3022
EP - 3026
UR - https://doi.org/10.37358/RC.17.12.6030
KW - biochemical metabolites
KW - metabolic abnormalities
KW - antipsychotics
KW - NAA-N-acetylaspartate
KW - GABA-Gama-Aminobutyric Acid
KW - N-MDA
ER -

BibTex
@article{RevCh2017P3022,
author = {Talpos Cristina and Ageu Luminita and Crisan Simina and Zamfir Carmen Lacramioara and Poroch Vladimir and Anghel Mirela},
title = {Metabolic Abnormalities and Spectroscopy Biochemical Cerebral Compounds Modifications in Children and Adolescents with Antipsychotic Treatment},
journal = {Revista de Chimie},
volume = {68},
number = {12},
pages = {3022-3026},
year = {2017},
issn = {2668-8212},
doi = {https://doi.org/10.37358/RC.17.12.6030},
url = {https://revistadechimie.ro/Articles.asp?ID=6030}
}

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