VASILE SIRBU, ANNAMARIA PALLAG, ANA HONIGES, VLADIMIR POROCH, SABINA IOANA COJOCARU CORRELATIONS BETWEEN OXIDATIVE STRESS AND APOPTOSIS DURING ANURAN METAMORPHOSIS The living organisms can trigger the defense mechanisms against free radicals, by synthesizing different antioxidant enzymes. The present study is focused on establishing some correlation between oxidative stress and the structural changes in cell death at the intestinal larval epithelium level during anuran metamorphosis. Cell death in such conditions may be regarded as the result of an interaction activity in which takes place apoptosis, autophagy, and necrosis, the cell choosing one or more. The amphibian metamorphosis is a complex process, divided into three major periods: prometamorphosis, premetamorphosis and climax. The process ensures the passage of the organism from aquatic to terrestrial life, with dramatic changes in the morphology and structure of some organs. In the climax stages of metamorphosis, a variety of free radicals are produced, starting a numerous cellular oxidation reactions.