GEORGETA ZEGAN, ELENA MIHAELA CARAUSU, LOREDANA GOLOVCENCU, ALINA SODOR BOTEZATU, EDUARD RADU CERNEI, DANIELA ANISTOROAEI ANTIBIOTIC-ANIONIC CLAY MATRIX USED FOR DRUG CONTROLLED RELEASE Anionic clay matrix acting as drug controlled release system have shown in last years a great potential for delivery of bioactive molecules and chemical therapeutics. This organic-inorganic nanohybrid system is high efficient offering an excellent protection of intercalated compounds from degradation. Compared to other nanoparticles used in medical area, anionic clays type layered double hydroxides have found to be biocompatible according to toxicological studies. Ampicillin containing MgAlLDHs and ZnAlLDH samples have been prepared following two routes: anion-exchange procedure and reconstruction from calcined layered double hydroxides. Solid samples have been characterized by FTIR and SEM-EDX highlighting the alteration of pristine LDHs structure when the antibiotic is introduced in the interlayer gallery.
Keywords: anionic clay, drug release, SEM-EDX, FTIR, orthodontics, public health dentistry