ELEONORA MARIAN, LAURA GRATIELA VICAS, TUNDE JURCA, MARIANA MURESAN, ANNAMARIA PALLAG, ROXANA LIANA STAN, BOGDAN SEVASTRE, ZORITA DIACONEASA, CORINA MARIA LUCIA IONESCU, ADRIANA CORINA HANGAN SALIVIA OFFICINALIS L. AND VERBASCUM PHLOMOIDES L. CHEMICAL, ANTIMICROBIAL, ANTIOXIDANT AND ANTITUMOR INVESTIGATIONS Due to the fact that the therapeutic activity of the Salvia officinalis L. is well-known, we aim to evaluate the therapeutic properties of the Verbascum phlomoides L. In the present study, we conducted extractive solutions of the both plant species after having undergone lyophilization for a better preservation of the active extracted ingredients. Lyophilized extracts were evaluated in terms of chemical composition. The polyphenolic content of the extracts was obtained using HPLC method, while the total polyphenol content (expressed in gallic acid) and total flavonoids content (expressed in quercetin) were quantified using spectrophotometric methods. The studies carried out have shown the protective effect of plant extracts against free radicals – antioxidant properties assessed by various methods (DPPH method, FRAP method, TEAC method, SOD-like activity in vivo), the antimicrobial activity and cytotoxicity assays. After evaluating the therapeutic properties of freeze-dried extracts of the two plants, they will be associated in the formulation of a mouthwash with known therapeutic properties.