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REVISTA DE CHIMIE
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https://doi.org/10.37358/Rev.Chim.1949

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Revista de Chimie (Rev. Chim.), Year 2018, Volume 69, Issue 3, 581-584

https://doi.org/10.37358/RC.18.3.6153

Claudia Mehedintu, Marina Antonovici, Lacramioara Brinduse, Elvira Bratila, Ruxandra Stanculescu, Costin Berceanu, Ovidiu Bratu, Silviu Pituru, Mircea Onofriescu, Daniela Roxana Matasariu

The Influence of Progesterone on Immunohystochemical Markers in Endometriosis

Abstract:

Endometriosis, one of the most common gynecologic pathologies, is defined as an inflammatory, estrogen-dependent disease characterized by the growth of endometrial stroma and glands outside the uterine cavity. It is a multifactorial disease, conditioned by genetic and immune factors and triggered by hormonal and environmental factors. Estrogen receptors (ER) and progesterone receptors (PR) expression is significantly modified in endometriotic tissue, compared to normal endometrium. We performed a prospective study that included 16 patients with endometriosis: 9 patients that underwent progesterone treatment with 0.075 mg desogestrel, daily for 24 weeks prior to the surgical procedure, and 7 patients that did not follow any kind of treatment. The purpose of the study was to evaluate the changes that occurred in the expression of ER, PR, B-cell lymphoma 2 (Bcl-2) and Ki-67 from the endometriotic tissue. Oral 0.075 mg desogestrel administration proved its benefits in the management of endometriomas.
Keywords:
endometriosis; progesterone receptor; estrogen receptor; Bcl-2; Ki-67

Issue: 2018, Volume 69, Issue 3
Pages: 581-584
Publication date: 2018/4/15
https://doi.org/10.37358/RC.18.3.6153
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Creative Commons License
This article is published under the Creative Commons Attribution 4.0 International License
Citation Styles
Cite this article as:
MEHEDINTU, C., ANTONOVICI, M., BRINDUSE, L., BRATILA, E., STANCULESCU, R., BERCEANU, C., BRATU, O., PITURU, S., ONOFRIESCU, M., MATASARIU, D.R., The Influence of Progesterone on Immunohystochemical Markers in Endometriosis, Rev. Chim., 69(3), 2018, 581-584.

Vancouver
Mehedintu C, Antonovici M, Brinduse L, Bratila E, Stanculescu R, Berceanu C, Bratu O, Pituru S, Onofriescu M, Matasariu DR. The Influence of Progesterone on Immunohystochemical Markers in Endometriosis. Rev. Chim.[internet]. 2018 Mar;69(3):581-584. Available from: https://doi.org/10.37358/RC.18.3.6153


APA 6th edition
Mehedintu, C., Antonovici, M., Brinduse, L., Bratila, E., Stanculescu, R., Berceanu, C.,... Matasariu, D.R. (2018). The Influence of Progesterone on Immunohystochemical Markers in Endometriosis. Revista de Chimie, 69(3), 581-584. https://doi.org/10.37358/RC.18.3.6153


Harvard
Mehedintu, C., Antonovici, M., Brinduse, L., Bratila, E., Stanculescu, R., Berceanu, C., Bratu, O., Pituru, S., Onofriescu, M., Matasariu, D.R. (2018). 'The Influence of Progesterone on Immunohystochemical Markers in Endometriosis', Revista de Chimie, 69(3), pp. 581-584. https://doi.org/10.37358/RC.18.3.6153


IEEE
C. Mehedintu, M. Antonovici, L. Brinduse, E. Bratila, R. Stanculescu, C. Berceanu, O. Bratu, S. Pituru, M. Onofriescu, D.R. Matasariu, "The Influence of Progesterone on Immunohystochemical Markers in Endometriosis". Revista de Chimie, vol. 69, no. 3, pp. 581-584, 2018. [online]. https://doi.org/10.37358/RC.18.3.6153


Text
Claudia Mehedintu, Marina Antonovici, Lacramioara Brinduse, Elvira Bratila, Ruxandra Stanculescu, Costin Berceanu, Ovidiu Bratu, Silviu Pituru, Mircea Onofriescu, Daniela Roxana Matasariu,
The Influence of Progesterone on Immunohystochemical Markers in Endometriosis,
Revista de Chimie,
Volume 69, Issue 3,
2018,
Pages 581-584,
ISSN 2668-8212,
https://doi.org/10.37358/RC.18.3.6153.
(https://revistadechimie.ro/Articles.asp?ID=6153)
Keywords: endometriosis; progesterone receptor; estrogen receptor; Bcl-2; Ki-67


RIS
TY - JOUR
T1 - The Influence of Progesterone on Immunohystochemical Markers in Endometriosis
A1 - Mehedintu, Claudia
A2 - Antonovici, Marina
A3 - Brinduse, Lacramioara
A4 - Bratila, Elvira
A5 - Stanculescu, Ruxandra
A6 - Berceanu, Costin
A7 - Bratu, Ovidiu
A8 - Pituru, Silviu
A9 - Onofriescu, Mircea
A10 - Matasariu, Daniela Roxana
JF - Revista de Chimie
JO - Rev. Chim.
PB - Revista de Chimie SRL
SN - 2668-8212
Y1 - 2018
VL - 69
IS - 3
SP - 581
EP - 584
UR - https://doi.org/10.37358/RC.18.3.6153
KW - endometriosis
KW - progesterone receptor
KW - estrogen receptor
KW - Bcl-2
KW - Ki-67
ER -


BibTex
@article{RevCh2018P581,
author = {Mehedintu Claudia and Antonovici Marina and Brinduse Lacramioara and Bratila Elvira and Stanculescu Ruxandra and Berceanu Costin and Bratu Ovidiu and Pituru Silviu and Onofriescu Mircea and Matasariu Daniela Roxana},
title = {The Influence of Progesterone on Immunohystochemical Markers in Endometriosis},
journal = {Revista de Chimie},
volume = {69},
number = {3},
pages = {581-584},
year = {2018},
issn = {2668-8212},
doi = {https://doi.org/10.37358/RC.18.3.6153},
url = {https://revistadechimie.ro/Articles.asp?ID=6153}
}
 
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