Long Term Efficacy of the Treatment with Olanzapine Pamoate, Risperidone and Aripiprazole Monohydrate

Fodor, Ana Aliana; Pascu, Alina Mihaela; Poroch, Vladimir; Ifteni, Petru Iulian; Burtea, Victoria; Toma, Sebastian; Baracan, Adrian; Gavris, Claudia; Teodorescu, Andreea

Ana Aliana Fodor, Alina Mihaela Pascu, Vladimir Poroch, Petru Iulian Ifteni, Victoria Burtea, Sebastian Toma, Adrian Baracan, Claudia Gavris, Andreea Teodorescu

Long Term Efficacy of the Treatment with Olanzapine Pamoate, Risperidone and Aripiprazole Monohydrate

Abstract:

The use of long-acting injectable antipsychotics (LAIs) is considered to be an important treatment option, especially in early stages of schizophrenia. The aim of this study was to evaluate the efficacy, safety and sustained remission in schizophrenia patients treated with three of the available LAIs substances: olanzapine pamoate, risperidone microspheres and aripiprazole monohydrate. A retrospective chart review study evaluating the efficacy of LAIs compared to oral antispychotics during a five years period was performed. Of the 102 patients included in the study, 52 (50.9%) continued LAIs: olanzapine pamoate (n = 20, 38.4%), risperidone microsphere (n = 22, 42.3%), aripiprazole monohydrate (n = 10, 19.3%). In the LAIs group the number of relapses was smaller than in the oral antipsychotics group (12 vs. 23, P [ 0.05) as well as the number of admissions (15 vs. 30, P [ 0.05). In conclusion, relapse in schizophrenia is strongly related to nonadherence. LAIs prescription overall was underutilized despite their efficacy. Future randomized studies are needed to evaluate the long term efficacy of LAIs compared to oral treatment.

Keywords:
LAIs substances; olanzapine pamoate; risperidone; aripiprazole monohydrate; oral antipsychotic; relapse

Issue: 2018, Volume 69, Issue 3

Pages: 650-653

Publication date: 2018/4/15

https://doi.org/10.37358/RC.18.3.6168

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This article is published under the Creative Commons Attribution 4.0 International License

Citation Styles

Cite this article as:
FODOR, A.A., PASCU, A.M., POROCH, V., IFTENI, P.I., BURTEA, V., TOMA, S., BARACAN, A., GAVRIS, C., TEODORESCU, A., Long Term Efficacy of the Treatment with Olanzapine Pamoate, Risperidone and Aripiprazole Monohydrate, Rev. Chim., 69(3), 2018, 650-653.

Vancouver
Fodor AA, Pascu AM, Poroch V, Ifteni PI, Burtea V, Toma S, Baracan A, Gavris C, Teodorescu A. Long Term Efficacy of the Treatment with Olanzapine Pamoate, Risperidone and Aripiprazole Monohydrate. Rev. Chim.[internet]. 2018 Mar;69(3):650-653. Available from: https://doi.org/10.37358/RC.18.3.6168

APA 6th edition
Fodor, A.A., Pascu, A.M., Poroch, V., Ifteni, P.I., Burtea, V., Toma, S.,... Teodorescu, A. (2018). Long Term Efficacy of the Treatment with Olanzapine Pamoate, Risperidone and Aripiprazole Monohydrate. Revista de Chimie, 69(3), 650-653. https://doi.org/10.37358/RC.18.3.6168

Harvard
Fodor, A.A., Pascu, A.M., Poroch, V., Ifteni, P.I., Burtea, V., Toma, S., Baracan, A., Gavris, C., Teodorescu, A. (2018). 'Long Term Efficacy of the Treatment with Olanzapine Pamoate, Risperidone and Aripiprazole Monohydrate', Revista de Chimie, 69(3), pp. 650-653. https://doi.org/10.37358/RC.18.3.6168

IEEE
A.A. Fodor, A.M. Pascu, V. Poroch, P.I. Ifteni, V. Burtea, S. Toma, A. Baracan, C. Gavris, A. Teodorescu, "Long Term Efficacy of the Treatment with Olanzapine Pamoate, Risperidone and Aripiprazole Monohydrate". Revista de Chimie, vol. 69, no. 3, pp. 650-653, 2018. [online]. https://doi.org/10.37358/RC.18.3.6168

Text
Ana Aliana Fodor, Alina Mihaela Pascu, Vladimir Poroch, Petru Iulian Ifteni, Victoria Burtea, Sebastian Toma, Adrian Baracan, Claudia Gavris, Andreea Teodorescu,
Long Term Efficacy of the Treatment with Olanzapine Pamoate, Risperidone and Aripiprazole Monohydrate,
Revista de Chimie,
Volume 69, Issue 3,
2018,
Pages 650-653,
ISSN 2668-8212,
https://doi.org/10.37358/RC.18.3.6168.
(https://revistadechimie.ro/Articles.asp?ID=6168)
Keywords: LAIs substances; olanzapine pamoate; risperidone; aripiprazole monohydrate; oral antipsychotic; relapse

RIS
TY - JOUR
T1 - Long Term Efficacy of the Treatment with Olanzapine Pamoate, Risperidone and Aripiprazole Monohydrate
A1 - Fodor, Ana Aliana
A2 - Pascu, Alina Mihaela
A3 - Poroch, Vladimir
A4 - Ifteni, Petru Iulian
A5 - Burtea, Victoria
A6 - Toma, Sebastian
A7 - Baracan, Adrian
A8 - Gavris, Claudia
A9 - Teodorescu, Andreea
JF - Revista de Chimie
JO - Rev. Chim.
PB - Revista de Chimie SRL
SN - 2668-8212
Y1 - 2018
VL - 69
IS - 3
SP - 650
EP - 653
UR - https://doi.org/10.37358/RC.18.3.6168
KW - LAIs substances
KW - olanzapine pamoate
KW - risperidone
KW - aripiprazole monohydrate
KW - oral antipsychotic
KW - relapse
ER -

BibTex
@article{RevCh2018P650,
author = {Fodor Ana Aliana and Pascu Alina Mihaela and Poroch Vladimir and Ifteni Petru Iulian and Burtea Victoria and Toma Sebastian and Baracan Adrian and Gavris Claudia and Teodorescu Andreea},
title = {Long Term Efficacy of the Treatment with Olanzapine Pamoate, Risperidone and Aripiprazole Monohydrate},
journal = {Revista de Chimie},
volume = {69},
number = {3},
pages = {650-653},
year = {2018},
issn = {2668-8212},
doi = {https://doi.org/10.37358/RC.18.3.6168},
url = {https://revistadechimie.ro/Articles.asp?ID=6168}
}

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