OLIMPIA DUMITRIU BUZIA, VALERIA FASIE, NELA MARDARE, CAMELIA DIACONU, GABRIELA GURAU, ALIN LAURENTIU TATU FORMULATION, PREPARATION, PHYSICO-CHIMICAL ANALYSIS, MICROBIOLOGICAL PECULIARITIES AND THERAPEUTIC CHALLENGES OF EXTRACTIVE SOLUTION OF KOMBUCHA This paper aimed at the preparation and characterisation of an extractive solution of Kombucha. We have applied the method of water extraction of a species of yeast, Kombucha, grown and proliferated in the pharmaceutical technology laboratory of the Faculty of Pharmacy at Dunarea de Jos University of Galati. Samples of various sugar concentrations have been prepared, as well as samples subject to concentration, thus obtaining extracts of up to 80% concentration. The extract obtained was analysed chemically and microbiologically. The main elements highlighted in the composition of the extractive solution were: iron, zinc, magnesium, calcium and potassium. The antimicrobial activity in strains: Gram-positive: Staphylococcus aureus, Gram-negative: Pseudomonas aeruginosa, Escherichia Coli, fungi: Candida albicans.