Relationship Between Gamma-glutamyl Transpeptidase Activity and Inflammatory Response in Lichen Planus

Mitran, Madalina Irina; Nicolae, Ilinca; Ene, Corina Daniela; Mitran, Cristina Iulia; Matei, Clara; Ene, Cosmin; Tampa, Mircea; Georgescu, Simona Roxana

Madalina Irina Mitran, Ilinca Nicolae, Corina Daniela Ene, Cristina Iulia Mitran, Clara Matei, Cosmin Ene, Mircea Tampa, Simona Roxana Georgescu

Relationship Between Gamma-glutamyl Transpeptidase Activity and Inflammatory Response in Lichen Planus

Abstract:

Chemicals used in the manufacture of synthetic fibers have been associated with undesirable side effects such as itching or skin lesions and it seems that they are involved in the induction of pathological processes such as oxidative stress and inflammation. Lichen planus (LP) can be regarded as an inflammatory disorder, chemical and physical factors playing an important role in the perpetuation of the inflammatory process. Gamma-glutamyl transpeptidase (GGT) plays an important role in the preservation of skin architecture and modulation of skin inflammation. In this study, we found that GGT activity is increased in LP patients with mild inflammation, whilst GGT is inactivated under conditions of severe inflammation. Therefore, GGT is involved in the inflammatory process, but there is no a positive correlation between its activity and the intensity of the inflammatory response. This functional adaptation of the enzyme may be due to down-regulation of its synthesis under free radical overload conditions. Understanding the molecular mechanisms involved in the modulation of intracellular redox homeostasis is an important step in the pharmacological management of patients with LP.

Keywords:
inflammation; lichen planus; gamma-glutamyl transpeptidase; C-reactive protein; sulfhydryl groups

Issue: 2018, Volume 69, Issue 3

Pages: 739-743

Publication date: 2018/4/15

https://doi.org/10.37358/RC.18.3.6189

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This article is published under the Creative Commons Attribution 4.0 International License

Citation Styles

Cite this article as:
MITRAN, M.I., NICOLAE, I., ENE, C.D., MITRAN, C.I., MATEI, C., ENE, C., TAMPA, M., GEORGESCU, S.R., Relationship Between Gamma-glutamyl Transpeptidase Activity and Inflammatory Response in Lichen Planus, Rev. Chim., 69(3), 2018, 739-743.

Vancouver
Mitran MI, Nicolae I, Ene CD, Mitran CI, Matei C, Ene C, Tampa M, Georgescu SR. Relationship Between Gamma-glutamyl Transpeptidase Activity and Inflammatory Response in Lichen Planus. Rev. Chim.[internet]. 2018 Mar;69(3):739-743. Available from: https://doi.org/10.37358/RC.18.3.6189

APA 6th edition
Mitran, M.I., Nicolae, I., Ene, C.D., Mitran, C.I., Matei, C., Ene, C., Tampa, M. & Georgescu, S.R. (2018). Relationship Between Gamma-glutamyl Transpeptidase Activity and Inflammatory Response in Lichen Planus. Revista de Chimie, 69(3), 739-743. https://doi.org/10.37358/RC.18.3.6189

Harvard
Mitran, M.I., Nicolae, I., Ene, C.D., Mitran, C.I., Matei, C., Ene, C., Tampa, M., Georgescu, S.R. (2018). 'Relationship Between Gamma-glutamyl Transpeptidase Activity and Inflammatory Response in Lichen Planus', Revista de Chimie, 69(3), pp. 739-743. https://doi.org/10.37358/RC.18.3.6189

IEEE
M.I. Mitran, I. Nicolae, C.D. Ene, C.I. Mitran, C. Matei, C. Ene, M. Tampa, S.R. Georgescu, "Relationship Between Gamma-glutamyl Transpeptidase Activity and Inflammatory Response in Lichen Planus". Revista de Chimie, vol. 69, no. 3, pp. 739-743, 2018. [online]. https://doi.org/10.37358/RC.18.3.6189

Text
Madalina Irina Mitran, Ilinca Nicolae, Corina Daniela Ene, Cristina Iulia Mitran, Clara Matei, Cosmin Ene, Mircea Tampa, Simona Roxana Georgescu,
Relationship Between Gamma-glutamyl Transpeptidase Activity and Inflammatory Response in Lichen Planus,
Revista de Chimie,
Volume 69, Issue 3,
2018,
Pages 739-743,
ISSN 2668-8212,
https://doi.org/10.37358/RC.18.3.6189.
(https://revistadechimie.ro/Articles.asp?ID=6189)
Keywords: inflammation; lichen planus; gamma-glutamyl transpeptidase; C-reactive protein; sulfhydryl groups

RIS
TY - JOUR
T1 - Relationship Between Gamma-glutamyl Transpeptidase Activity and Inflammatory Response in Lichen Planus
A1 - Mitran, Madalina Irina
A2 - Nicolae, Ilinca
A3 - Ene, Corina Daniela
A4 - Mitran, Cristina Iulia
A5 - Matei, Clara
A6 - Ene, Cosmin
A7 - Tampa, Mircea
A8 - Georgescu, Simona Roxana
JF - Revista de Chimie
JO - Rev. Chim.
PB - Revista de Chimie SRL
SN - 2668-8212
Y1 - 2018
VL - 69
IS - 3
SP - 739
EP - 743
UR - https://doi.org/10.37358/RC.18.3.6189
KW - inflammation
KW - lichen planus
KW - gamma-glutamyl transpeptidase
KW - C-reactive protein
KW - sulfhydryl groups
ER -

BibTex
@article{RevCh2018P739,
author = {Mitran Madalina Irina and Nicolae Ilinca and Ene Corina Daniela and Mitran Cristina Iulia and Matei Clara and Ene Cosmin and Tampa Mircea and Georgescu Simona Roxana},
title = {Relationship Between Gamma-glutamyl Transpeptidase Activity and Inflammatory Response in Lichen Planus},
journal = {Revista de Chimie},
volume = {69},
number = {3},
pages = {739-743},
year = {2018},
issn = {2668-8212},
doi = {https://doi.org/10.37358/RC.18.3.6189},
url = {https://revistadechimie.ro/Articles.asp?ID=6189}
}

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