The Role of Anticoagulant Therapy with Heparine in Treatment of Acute Hand Ischemia

Zeca, Cristina Elena Berbecar; Iordache, Madalina Elena; Muraru, Iulia; Muraru, Dragos; Stanciulescu, Elena Luminita; Jinescu, George; Zarnescu, Mircea Bogdan Maciuceanu; Mares, Alina Monica

Cristina Elena Berbecar Zeca, Madalina Elena Iordache, Iulia Muraru, Dragos Muraru, Elena Luminita Stanciulescu, George Jinescu, Mircea Bogdan Maciuceanu Zarnescu, Alina Monica Mares

The Role of Anticoagulant Therapy with Heparine in Treatment of Acute Hand Ischemia

Abstract:

Hand ischaemia has multiple causes. The Methadone (C21H27NO) - opioid family of drugs and Alprazolam (C17H13Cl1N4) microcrystals, available under the trade name Xanax - benzodiazepine anxiolytic, when using in case of drugs abuser, are very powerful embolic agents which can cause thrombosis of small vessels. Microvascular embolization caused by microcrystals of the injectable powder has contributed to the process of ischaemia. This paper brings into discussions a case of acute ischaemia of the right hand due to intra-arterial injection of suspended tablets of Methadone and Alprazolam microcrystals into the right radial artery, in the distal 1/3 of the forearm.The therapeutic management consisted of restoring the arterial circulation at the ischaemic segment to prevent the propagation of thromboembolic complications by using of i.v. heparine and to preserve the function of the hand by preventing delayed ischaemia and compartment syndrome followed by necrosis. Heparin is a drug widely used in the treatment and prevention of arterial and venous thrombosis. The main effect of heparins lies in their anticoagulant activity. Heparins are involved in different pathways of the coagulation cascade with anticoagulant, antithrombotic, profibrinolytic, anti-aggregative, as well as anti-inflammatory effects.This paper aims to discuss a severe case of ischaemia which demonstrates that intra-arterial injection of oral drugs can lead to limb loss with currently accepted therapy.

Keywords:
Heparin; Methadone; Alprazolam; intraarterial injection in drug abuse; hand ischaemia

Issue: 2018, Volume 69, Issue 3

Pages: 752-754

Publication date: 2018/4/15

https://doi.org/10.37358/RC.18.3.6192

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This article is published under the Creative Commons Attribution 4.0 International License

Citation Styles

Cite this article as:
ZECA, C.E.B., IORDACHE, M.E., MURARU, I., MURARU, D., STANCIULESCU, E.L., JINESCU, G., ZARNESCU, M.B.M., MARES, A.M., The Role of Anticoagulant Therapy with Heparine in Treatment of Acute Hand Ischemia, Rev. Chim., 69(3), 2018, 752-754.

Vancouver
Zeca CEB, Iordache ME, Muraru I, Muraru D, Stanciulescu EL, Jinescu G, Zarnescu MBM, Mares AM. The Role of Anticoagulant Therapy with Heparine in Treatment of Acute Hand Ischemia. Rev. Chim.[internet]. 2018 Mar;69(3):752-754. Available from: https://doi.org/10.37358/RC.18.3.6192

APA 6th edition
Zeca, C.E.B., Iordache, M.E., Muraru, I., Muraru, D., Stanciulescu, E.L., Jinescu, G., Zarnescu, M.B.M. & Mares, A.M. (2018). The Role of Anticoagulant Therapy with Heparine in Treatment of Acute Hand Ischemia. Revista de Chimie, 69(3), 752-754. https://doi.org/10.37358/RC.18.3.6192

Harvard
Zeca, C.E.B., Iordache, M.E., Muraru, I., Muraru, D., Stanciulescu, E.L., Jinescu, G., Zarnescu, M.B.M., Mares, A.M. (2018). 'The Role of Anticoagulant Therapy with Heparine in Treatment of Acute Hand Ischemia', Revista de Chimie, 69(3), pp. 752-754. https://doi.org/10.37358/RC.18.3.6192

IEEE
C.E.B. Zeca, M.E. Iordache, I. Muraru, D. Muraru, E.L. Stanciulescu, G. Jinescu, M.B.M. Zarnescu, A.M. Mares, "The Role of Anticoagulant Therapy with Heparine in Treatment of Acute Hand Ischemia". Revista de Chimie, vol. 69, no. 3, pp. 752-754, 2018. [online]. https://doi.org/10.37358/RC.18.3.6192

Text
Cristina Elena Berbecar Zeca, Madalina Elena Iordache, Iulia Muraru, Dragos Muraru, Elena Luminita Stanciulescu, George Jinescu, Mircea Bogdan Maciuceanu Zarnescu, Alina Monica Mares,
The Role of Anticoagulant Therapy with Heparine in Treatment of Acute Hand Ischemia,
Revista de Chimie,
Volume 69, Issue 3,
2018,
Pages 752-754,
ISSN 2668-8212,
https://doi.org/10.37358/RC.18.3.6192.
(https://revistadechimie.ro/Articles.asp?ID=6192)
Keywords: Heparin; Methadone; Alprazolam; intraarterial injection in drug abuse; hand ischaemia

RIS
TY - JOUR
T1 - The Role of Anticoagulant Therapy with Heparine in Treatment of Acute Hand Ischemia
A1 - Zeca, Cristina Elena Berbecar
A2 - Iordache, Madalina Elena
A3 - Muraru, Iulia
A4 - Muraru, Dragos
A5 - Stanciulescu, Elena Luminita
A6 - Jinescu, George
A7 - Zarnescu, Mircea Bogdan Maciuceanu
A8 - Mares, Alina Monica
JF - Revista de Chimie
JO - Rev. Chim.
PB - Revista de Chimie SRL
SN - 2668-8212
Y1 - 2018
VL - 69
IS - 3
SP - 752
EP - 754
UR - https://doi.org/10.37358/RC.18.3.6192
KW - Heparin
KW - Methadone
KW - Alprazolam
KW - intraarterial injection in drug abuse
KW - hand ischaemia
ER -

BibTex
@article{RevCh2018P752,
author = {Zeca Cristina Elena Berbecar and Iordache Madalina Elena and Muraru Iulia and Muraru Dragos and Stanciulescu Elena Luminita and Jinescu George and Zarnescu Mircea Bogdan Maciuceanu and Mares Alina Monica},
title = {The Role of Anticoagulant Therapy with Heparine in Treatment of Acute Hand Ischemia},
journal = {Revista de Chimie},
volume = {69},
number = {3},
pages = {752-754},
year = {2018},
issn = {2668-8212},
doi = {https://doi.org/10.37358/RC.18.3.6192},
url = {https://revistadechimie.ro/Articles.asp?ID=6192}
}

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