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https://doi.org/10.37358/Rev.Chim.1949

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Revista de Chimie (Rev. Chim.), Year 2018, Volume 69, Issue 4, 965-970

https://doi.org/10.37358/RC.18.4.6238

Laura Alexandra Nussbaum, Lavinia Maria Hogea, Roxana Folescu, Mirela Loredana Grigoras, Carmen Lacramioara Zamfir, Mihaela Boanca, Dragos Erdelean, Elena Cecilia Ildiko Rosca, Liliana Nussbaum, Mihaela Adriana Simu, Viorel Lupu

Biochemical Modifications Study of Cerebral Metabolites by Spectroscopy in Epilepsy Treatment

Abstract:

Through this research, our main focus was: to investigate the biochemical brain metabolites (NAA-N-acetylaspartate, GABA-Gama-Aminobutyric Acid, Asp-Aspartate, CR-Creatine, Gln-Glutamine, GPC-Glicerophosphocholine, PC-Phosphocholine, PCr-Phosphocreatine, Tau-Taurine, N-MDA-N-Metyl-D-Aspartate, Serine, Glicine, Cho-Choline); the neuroimagistic, the brain biochemical and metabolic abnormalities in children and adolescents with epilepsy before and after treatment; to review the main antiepileptic medication administered to these patients; and to make some correlations with the results obtained through Magnetic Resonance (MR) Spectroscopy, for further proper early detection and intervention in children and adolescents with epilepsy. Our research was performed between 2010-2017, involving 45 children and adolescents with epilepsy. Also, the patients were evaluated through MR Spectroscopy at baseline and after pharmacotherapy. Through the MR Spectroscopy, we investigated key aspects of the brain function and metabolism. The antiepileptic medication was chosen according to the guides and the type of epileptic seizures. The efficacy of the chosen therapy was evaluated through the change of the relevant MR spectroscopy biochemical brain metabolites. Our results, showed statistically significant modified values and concentrations of the biochemical cerebral metabolites. Our research was a proof, which the evaluation of the biochemical brain metabolites through MR Spectroscopy is of high clinical utility in prevention, early detection and intervention in epilepsy in children and adolescents.
Keywords:
biochemical metabolites; NAA-N-acetylaspartate; GABA-Gama-Aminobutyric Acid; glutamate; epilepsy; antiepileptic medication

Issue: 2018, Volume 69, Issue 4
Pages: 965-970
Publication date: 2018/5/15
https://doi.org/10.37358/RC.18.4.6238
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Creative Commons License
This article is published under the Creative Commons Attribution 4.0 International License
Citation Styles
Cite this article as:
NUSSBAUM, L.A., HOGEA, L.M., FOLESCU, R., GRIGORAS, M.L., ZAMFIR, C.L., BOANCA, M., ERDELEAN, D., ROSCA, E.C.I., NUSSBAUM, L., SIMU, M.A., LUPU, V., Biochemical Modifications Study of Cerebral Metabolites by Spectroscopy in Epilepsy Treatment, Rev. Chim., 69(4), 2018, 965-970.

Vancouver
Nussbaum LA, Hogea LM, Folescu R, Grigoras ML, Zamfir CL, Boanca M, Erdelean D, Rosca ECI, Nussbaum L, Simu MA, Lupu V. Biochemical Modifications Study of Cerebral Metabolites by Spectroscopy in Epilepsy Treatment. Rev. Chim.[internet]. 2018 Apr;69(4):965-970. Available from: https://doi.org/10.37358/RC.18.4.6238


APA 6th edition
Nussbaum, L.A., Hogea, L.M., Folescu, R., Grigoras, M.L., Zamfir, C.L., Boanca, M.,... Lupu, V. (2018). Biochemical Modifications Study of Cerebral Metabolites by Spectroscopy in Epilepsy Treatment. Revista de Chimie, 69(4), 965-970. https://doi.org/10.37358/RC.18.4.6238


Harvard
Nussbaum, L.A., Hogea, L.M., Folescu, R., Grigoras, M.L., Zamfir, C.L., Boanca, M., Erdelean, D., Rosca, E.C.I., Nussbaum, L., Simu, M.A., Lupu, V. (2018). 'Biochemical Modifications Study of Cerebral Metabolites by Spectroscopy in Epilepsy Treatment', Revista de Chimie, 69(4), pp. 965-970. https://doi.org/10.37358/RC.18.4.6238


IEEE
L.A. Nussbaum, L.M. Hogea, R. Folescu, M.L. Grigoras, C.L. Zamfir, M. Boanca, D. Erdelean, E.C.I. Rosca, L. Nussbaum, M.A. Simu, V. Lupu, "Biochemical Modifications Study of Cerebral Metabolites by Spectroscopy in Epilepsy Treatment". Revista de Chimie, vol. 69, no. 4, pp. 965-970, 2018. [online]. https://doi.org/10.37358/RC.18.4.6238


Text
Laura Alexandra Nussbaum, Lavinia Maria Hogea, Roxana Folescu, Mirela Loredana Grigoras, Carmen Lacramioara Zamfir, Mihaela Boanca, Dragos Erdelean, Elena Cecilia Ildiko Rosca, Liliana Nussbaum, Mihaela Adriana Simu, Viorel Lupu,
Biochemical Modifications Study of Cerebral Metabolites by Spectroscopy in Epilepsy Treatment,
Revista de Chimie,
Volume 69, Issue 4,
2018,
Pages 965-970,
ISSN 2668-8212,
https://doi.org/10.37358/RC.18.4.6238.
(https://revistadechimie.ro/Articles.asp?ID=6238)
Keywords: biochemical metabolites; NAA-N-acetylaspartate; GABA-Gama-Aminobutyric Acid; glutamate; epilepsy; antiepileptic medication


RIS
TY - JOUR
T1 - Biochemical Modifications Study of Cerebral Metabolites by Spectroscopy in Epilepsy Treatment
A1 - Nussbaum, Laura Alexandra
A2 - Hogea, Lavinia Maria
A3 - Folescu, Roxana
A4 - Grigoras, Mirela Loredana
A5 - Zamfir, Carmen Lacramioara
A6 - Boanca, Mihaela
A7 - Erdelean, Dragos
A8 - Rosca, Elena Cecilia Ildiko
A9 - Nussbaum, Liliana
A10 - Simu, Mihaela Adriana
A11 - Lupu, Viorel
JF - Revista de Chimie
JO - Rev. Chim.
PB - Revista de Chimie SRL
SN - 2668-8212
Y1 - 2018
VL - 69
IS - 4
SP - 965
EP - 970
UR - https://doi.org/10.37358/RC.18.4.6238
KW - biochemical metabolites
KW - NAA-N-acetylaspartate
KW - GABA-Gama-Aminobutyric Acid
KW - glutamate
KW - epilepsy
KW - antiepileptic medication
ER -


BibTex
@article{RevCh2018P965,
author = {Nussbaum Laura Alexandra and Hogea Lavinia Maria and Folescu Roxana and Grigoras Mirela Loredana and Zamfir Carmen Lacramioara and Boanca Mihaela and Erdelean Dragos and Rosca Elena Cecilia Ildiko and Nussbaum Liliana and Simu Mihaela Adriana and Lupu Viorel},
title = {Biochemical Modifications Study of Cerebral Metabolites by Spectroscopy in Epilepsy Treatment},
journal = {Revista de Chimie},
volume = {69},
number = {4},
pages = {965-970},
year = {2018},
issn = {2668-8212},
doi = {https://doi.org/10.37358/RC.18.4.6238},
url = {https://revistadechimie.ro/Articles.asp?ID=6238}
}
 
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