ABOUT INDEXING BOARD ARCHIVES AUTHOR GUIDELINES SUBMIT PAPER AUTHOR'S PAGE NEWS, EVENTS CONTACT
REVISTA DE CHIMIE
Cite as: Rev. Chim.
https://doi.org/10.37358/Rev.Chim.1949

OSIM Nr. R102355
ISSN Online 2668-8212
ISSN Print: 1582-9049
ISSN-L: 1582-9049

REVISTA DE CHIMIE Latest Issue

LATEST ISSUE >>>

   Volume 75, 2024
   Volume 74, 2023
   Volume 73, 2022
   Volume 72, 2021
   Volume 71, 2020
   Volume 70, 2019
   Volume 69, 2018
   Volume 68, 2017
   Volume 67, 2016
   Volume 66, 2015
   Volume 65, 2014
   Volume 64, 2013
   Volume 63, 2012
   Volume 62, 2011
   Volume 61, 2010
   Volume 60, 2009
   Volume 59, 2008
   Volume 58, 2007
 
<<<< back

Revista de Chimie (Rev. Chim.), Year 2018, Volume 69, Issue 5, 1099-1105

https://doi.org/10.37358/RC.18.5.6268

Violeta Bojinca, Claudiu Popescu, Andra Rodica Balanescu, Serban Mihai Balanescu, Mihai Bojinca

Osteoporosis and Bone Metabolism in Treatment-naive Primary Prostate Adenocarcinoma Patients


Abstract:

The objectives of the study were to evaluate bone metabolism in primary prostate cancer (PCa) patients prior to any treatment and to compare estrogens and anti-androgens in terms of bone metabolism. The study prospectively included consecutive patients with primary PCa who were proposed for radical prostatectomy and androgen deprivation therapy (ADT; either estrogens-group E, or anti-androgens -group A) and age-matched controls. Bone markers (osteoprotegerin -OPG; osteocalcin; deoxypyridinoline) were measured before treatment and after 6 months. Bone mineral density (BMD) was measured by dual X-ray absorptiometry before treatment and after 12 months (osteoporosis was defined as a spine or hip T score £ -2.5). Continuous variables are reported as mean ± standard deviation. The study included 30 controls (aged 70 ± 6 years), 15 patients treated with estrogens (aged 71 ± 6 years) and 15 patients with anti-androgens (aged 72 ± 5 years). At baseline, 0% of controls, 33.3% of group E (p = 0.002 versus controls) and 53.3% of group A (p = 0.0001 versus controls) had osteoporosis. In group E, compared to baseline, OPG (4.67 ± 1.38 versus 5.27 ± 1.89; p = 0.043) and DPD (6.85 ± 3.24 versus 8.63 ± 2.42; p = 0.008) increased, while spine (0.99 ± 0.32 versus 0.94 ± 0.31; p = 0.019) BMD decreased. In group A, compared to baseline, OPG (6.37 ± 3.04 versus 5.02 ± 1.12; p = 0.041), spine (1.03 ± 0.15 versus 0.89 ± 0.15; p = 0.0003) and hip (0.82 ± 0.18 versus 0.75 ± 0.17; p = 0.003) BMD decreased. Osteoporosis is prevalent among hormone-naïve PCa patients. Estrogens are associated with an increase of serum OPG, while anti-androgens with a decrease of serum OPG. Irrespective of ADT type, BMD still decreases in primary PCa patients.
Keywords:
androgen deprivation therapy; prostate cancer; osteoporosis

Issue: 2018, Volume 69, Issue 5
Pages: 1099-1105
Publication date: 2018/6/15
https://doi.org/10.37358/RC.18.5.6268
download pdf   Download Pdf Article
Creative Commons License
This article is published under the Creative Commons Attribution 4.0 International License
Citation Styles
Cite this article as:
BOJINCA, V., POPESCU, C., BALANESCU, A.R., BALANESCU, S.M., BOJINCA, M., Osteoporosis and Bone Metabolism in Treatment-naive Primary Prostate Adenocarcinoma Patients
, Rev. Chim., 69(5), 2018, 1099-1105.

Vancouver
Bojinca V, Popescu C, Balanescu AR, Balanescu SM, Bojinca M. Osteoporosis and Bone Metabolism in Treatment-naive Primary Prostate Adenocarcinoma Patients
. Rev. Chim.[internet]. 2018 May;69(5):1099-1105. Available from: https://doi.org/10.37358/RC.18.5.6268


APA 6th edition
Bojinca, V., Popescu, C., Balanescu, A.R., Balanescu, S.M. & Bojinca, M. (2018). Osteoporosis and Bone Metabolism in Treatment-naive Primary Prostate Adenocarcinoma Patients
. Revista de Chimie, 69(5), 1099-1105. https://doi.org/10.37358/RC.18.5.6268


Harvard
Bojinca, V., Popescu, C., Balanescu, A.R., Balanescu, S.M., Bojinca, M. (2018). 'Osteoporosis and Bone Metabolism in Treatment-naive Primary Prostate Adenocarcinoma Patients
', Revista de Chimie, 69(5), pp. 1099-1105. https://doi.org/10.37358/RC.18.5.6268


IEEE
V. Bojinca, C. Popescu, A.R. Balanescu, S.M. Balanescu, M. Bojinca, "Osteoporosis and Bone Metabolism in Treatment-naive Primary Prostate Adenocarcinoma Patients
". Revista de Chimie, vol. 69, no. 5, pp. 1099-1105, 2018. [online]. https://doi.org/10.37358/RC.18.5.6268


Text
Violeta Bojinca, Claudiu Popescu, Andra Rodica Balanescu, Serban Mihai Balanescu, Mihai Bojinca,
Osteoporosis and Bone Metabolism in Treatment-naive Primary Prostate Adenocarcinoma Patients
,
Revista de Chimie,
Volume 69, Issue 5,
2018,
Pages 1099-1105,
ISSN 2668-8212,
https://doi.org/10.37358/RC.18.5.6268.
(https://revistadechimie.ro/Articles.asp?ID=6268)
Keywords: androgen deprivation therapy; prostate cancer; osteoporosis


RIS
TY - JOUR
T1 - Osteoporosis and Bone Metabolism in Treatment-naive Primary Prostate Adenocarcinoma Patients

A1 - Bojinca, Violeta
A2 - Popescu, Claudiu
A3 - Balanescu, Andra Rodica
A4 - Balanescu, Serban Mihai
A5 - Bojinca, Mihai
JF - Revista de Chimie
JO - Rev. Chim.
PB - Revista de Chimie SRL
SN - 2668-8212
Y1 - 2018
VL - 69
IS - 5
SP - 1099
EP - 1105
UR - https://doi.org/10.37358/RC.18.5.6268
KW - androgen deprivation therapy
KW - prostate cancer
KW - osteoporosis
ER -


BibTex
@article{RevCh2018P1099,
author = {Bojinca Violeta and Popescu Claudiu and Balanescu Andra Rodica and Balanescu Serban Mihai and Bojinca Mihai},
title = {Osteoporosis and Bone Metabolism in Treatment-naive Primary Prostate Adenocarcinoma Patients
},
journal = {Revista de Chimie},
volume = {69},
number = {5},
pages = {1099-1105},
year = {2018},
issn = {2668-8212},
doi = {https://doi.org/10.37358/RC.18.5.6268},
url = {https://revistadechimie.ro/Articles.asp?ID=6268}
}
 
<<<< back
 
PUBLISHING SECTION
Author Guidelines
 * Paper Drafting
 * Paper Template
 * Ethical Statement
 * Paper Submission
Ghidul Autorului (ro)
Submit Paper
Author's Page
Publishing Ethics
Peer Review Process
Open Access & Archiving Policy
 Search Authors
 LATEST NEWS
REvista de Chimie NUMAR OMAGIAL PETRU PONI.. detalii
REvista de Chimie Revista de Chimie - 70 de ani de aparitie neintrerupta.. detalii
dictionar English-Romanian Dictionary for Mechanical Engineering
(download pdf)
  News, Events
Crossref Member Badge
 DOI  logo
 Gold Open Access | Source=http://www.plos.org/  | Author=art designer at PLoS
Creative Commons License
 Conferences of Contemporary
 Chemistry
 Biblioteca Chimiei
 Materiale Plastice