DANIELA G. BALAN, DAN PIPEREA SIANU, IULIA I. STANESCU, DORIN IONESCU, ANDRA ELENA STROESCU BALCANGIU, LAURA RADUCU, SILVIA MARIA STOICESCU, ADELA M. CEAU, CATALIN TILISCAN, VANDA ROXANA NIMIGEAN, VIORICA TARMURE, ALEXANDRU G. CROITORU A COMPARATIVE EVALUATION OF SERUM AND SALIVARY TOTAL PROTEINS AND IMMUNOGLOBULINS IN PATIENTS WITH HEPATITIS A AND HEALTHY SUBJECTS Assessment of changes in total proteins level, serum and saliva IgG and IgA levels, serum IgM level, serum and saliva IgA/IgG ratio. The study was conducted on a group of 40 subjects, divided into 2 lots: the first lot consisting of 20 healthy individuals and the second consisting of 20 patients with hepatitis with hepatitis A virus (HAV). The levels of total proteins, serum and saliva IgG and IgA, serum IgM and serum and saliva IgA/IgG ratio have higher values in patients with hepatitis A, in comparison to healthy subjects, without necessarily exceeding the maximum admitted value. The results are significant from a statistical point of view. Due to the sensitivity and specificity of salivary anti-HAV IgM and IgG in patients with acute hepatitis A, compared with healthy subjects, there is a possibility of using salivary immunological tests instead of serum tests for the diagnosis and epidemiological study of HAV infection.
Keywords: hepatitis A, immunoglobulins, total proteins, saliva, serum