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https://doi.org/10.37358/Rev.Chim.1949

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Revista de Chimie (Rev. Chim.), Year 2018, Volume 69, Issue 5, 1134-1138

https://doi.org/10.37358/RC.18.5.6275

Veronica Calborean, Victor Gheorman, Octavian Istratoaie, Roxana Edme Mustafa, Petre Alexandru Cojocaru, Dragos Ovidiu Alexandru, Oana Galceava, Adrian Mita, Silvia Alina Miscoci, Razan Al Namat, Dan Ionut Gheonea

QT Interval Analysis in Patients with Chronic Liver Disease

Abstract:

The prevalance of QT prolongation in chronic viral liver disease is high and the risk of complications is increased. We wanted to study the QT interval prolongation at the patients diagnosed with chronic hepatic disease and also to evaluate some of clinical and biochemical variables. We studied a cohort with 126 patients diagnosed with chronic viral hepatic diseases hospitalised to Cardiology Department, to the County Hospital of Craiova, between Octomber 2016 and January 2018. We aimed to determine the occurrence of QT interval prolongation in a large series of patients with chronic hepatic disease of viral etiology. We wanted to evaluated the QT prolongation to clinical and biochemical variables. The QT interval was measured by a standard 12-lead ECG for each patient, with prolongation defined as 460 ms. Multiple clinical and biochemical variables were evaluated including sex, age, areas (rural/urban) the frequency of arrhythmic events (PACs, PVCs, Atrial fibrillation, Bradycardia, Tachycardia), NT proBNP, Hb,uric acid, creatinine, alanine aminotransferase (ALT), aspartate aminotransferase (AST) , cholesterol, triglyceride, etc. The group of patients was composed by 43 woman and 83 men. From 43 women, representing 65.06% (461.56 ±42.03) and from 83 men, means 66.67% (461.14 ± 45.10) presented interval QT prolongation. Studing the distribution of hepatic etiologies we can see that 34 patients had hepatitis B, 35 patients hepatitis C, 5 patients B and C dual virus infection and 52 patients with chronic liver disease of etiology other than viral. We registered close results about QT interval prolongation on group, sex and origine group of patients. The value of QT interval to our patients was higher compared to other values recorder in other studies, at the patients with chronic hepatic disease, despide the fact we chose a higher value of QT prolongation. The highest value of QT interval was in the group of age between 60 and 69, even if in other studies we notice a prolonged QT interval at patients over 70 years old. The biological and biochemical profile of chronic hepatic disease of the subjects included in our study showed no statistical difference between male and female patients.We found a higher incidence of arrhythmic events, at patients with chronic hepatic disease of viral etiology, especially to premature atrial contraction and atrial fibrillation.We found a couple of correlation between QT interval prolongation and the evolution of chronic hepatic disease of viral etiology. It is very important to develop a strong and complex strategies to prevent and to treat the arrhythmic event presented at the patients diagnosticated with hepatic disease, because of the higher risk of developing life-threatening arrhythmias, includen sudden cardiac death.
Keywords:
Hepatic disease; Arrhythmia; QT interval prolongation

Issue: 2018, Volume 69, Issue 5
Pages: 1134-1138
Publication date: 2018/6/15
https://doi.org/10.37358/RC.18.5.6275
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Creative Commons License
This article is published under the Creative Commons Attribution 4.0 International License
Citation Styles
Cite this article as:
CALBOREAN, V., GHEORMAN, V., ISTRATOAIE, O., MUSTAFA, R.E., COJOCARU, P.A., ALEXANDRU, D.O., GALCEAVA, O., MITA, A., MISCOCI, S.A., NAMAT, R.A., GHEONEA, D.I., QT Interval Analysis in Patients with Chronic Liver Disease, Rev. Chim., 69(5), 2018, 1134-1138.

Vancouver
Calborean V, Gheorman V, Istratoaie O, Mustafa RE, Cojocaru PA, Alexandru DO, Galceava O, Mita A, Miscoci SA, Namat RA, Gheonea DI. QT Interval Analysis in Patients with Chronic Liver Disease. Rev. Chim.[internet]. 2018 May;69(5):1134-1138. Available from: https://doi.org/10.37358/RC.18.5.6275


APA 6th edition
Calborean, V., Gheorman, V., Istratoaie, O., Mustafa, R.E., Cojocaru, P.A., Alexandru, D.O.,... Gheonea, D.I. (2018). QT Interval Analysis in Patients with Chronic Liver Disease. Revista de Chimie, 69(5), 1134-1138. https://doi.org/10.37358/RC.18.5.6275


Harvard
Calborean, V., Gheorman, V., Istratoaie, O., Mustafa, R.E., Cojocaru, P.A., Alexandru, D.O., Galceava, O., Mita, A., Miscoci, S.A., Namat, R.A., Gheonea, D.I. (2018). 'QT Interval Analysis in Patients with Chronic Liver Disease', Revista de Chimie, 69(5), pp. 1134-1138. https://doi.org/10.37358/RC.18.5.6275


IEEE
V. Calborean, V. Gheorman, O. Istratoaie, R.E. Mustafa, P.A. Cojocaru, D.O. Alexandru, O. Galceava, A. Mita, S.A. Miscoci, R.A. Namat, D.I. Gheonea, "QT Interval Analysis in Patients with Chronic Liver Disease". Revista de Chimie, vol. 69, no. 5, pp. 1134-1138, 2018. [online]. https://doi.org/10.37358/RC.18.5.6275


Text
Veronica Calborean, Victor Gheorman, Octavian Istratoaie, Roxana Edme Mustafa, Petre Alexandru Cojocaru, Dragos Ovidiu Alexandru, Oana Galceava, Adrian Mita, Silvia Alina Miscoci, Razan Al Namat, Dan Ionut Gheonea,
QT Interval Analysis in Patients with Chronic Liver Disease,
Revista de Chimie,
Volume 69, Issue 5,
2018,
Pages 1134-1138,
ISSN 2668-8212,
https://doi.org/10.37358/RC.18.5.6275.
(https://revistadechimie.ro/Articles.asp?ID=6275)
Keywords: Hepatic disease; Arrhythmia; QT interval prolongation


RIS
TY - JOUR
T1 - QT Interval Analysis in Patients with Chronic Liver Disease
A1 - Calborean, Veronica
A2 - Gheorman, Victor
A3 - Istratoaie, Octavian
A4 - Mustafa, Roxana Edme
A5 - Cojocaru, Petre Alexandru
A6 - Alexandru, Dragos Ovidiu
A7 - Galceava, Oana
A8 - Mita, Adrian
A9 - Miscoci, Silvia Alina
A10 - Namat, Razan Al
A11 - Gheonea, Dan Ionut
JF - Revista de Chimie
JO - Rev. Chim.
PB - Revista de Chimie SRL
SN - 2668-8212
Y1 - 2018
VL - 69
IS - 5
SP - 1134
EP - 1138
UR - https://doi.org/10.37358/RC.18.5.6275
KW - Hepatic disease
KW - Arrhythmia
KW - QT interval prolongation
ER -


BibTex
@article{RevCh2018P1134,
author = {Calborean Veronica and Gheorman Victor and Istratoaie Octavian and Mustafa Roxana Edme and Cojocaru Petre Alexandru and Alexandru Dragos Ovidiu and Galceava Oana and Mita Adrian and Miscoci Silvia Alina and Namat Razan Al and Gheonea Dan Ionut},
title = {QT Interval Analysis in Patients with Chronic Liver Disease},
journal = {Revista de Chimie},
volume = {69},
number = {5},
pages = {1134-1138},
year = {2018},
issn = {2668-8212},
doi = {https://doi.org/10.37358/RC.18.5.6275},
url = {https://revistadechimie.ro/Articles.asp?ID=6275}
}
 
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