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https://doi.org/10.37358/Rev.Chim.1949

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Revista de Chimie (Rev. Chim.), Year 2018, Volume 69, Issue 5, 1173-1178

https://doi.org/10.37358/RC.18.5.6283

Laurentiu Pirtea, Dorin Grigoras, Cristina Secosan, Ioan Sas, Razvan Ilina, Adriana Andreea Jitariu, Ovidiu Alexandru Mederle

Clinical and Histopathological Parameters Correlate with Microvessel Density but Not with Vascular Endothelial Growth Factor Expression in Ovarian Cancer

Abstract:

Ovarian cancer malignancies have the worst prognosis among all gynecological malignancies. As angiogenesis represents a key step for tumor progression, vascular endothelial growth factor (VEGF) is one of the most discussed pro-angiogenic factors. VEGF expression was investigated in 62 cases of ovarian carcinomas. Microvessel density (MVD) was evaluated by correlating the results with clinical and histopathological parameters. Because of the controversial results reported in other studies, VEGF was assessed together with MVD. Our results suggest a more complex angiogenic mechanism in ovarian cancer based on the discrepancies between VEGF expression, microvessel density and their correlation with clinical parameters. The conflicting data arising from this study supports the implications of different growth factors, others than VEGF in ovarian cancer. This hypothesis is sustained by the lack of correlation between VEGF and clinical parameters, and by the significant correlation between microvessel density and clinicopathological parameters. Thus, further studies are needed for a complete evaluation of angiogenesis in ovarian cancer.
Keywords:
VEGF; MVD; ovarian cancer; angiogenesis; growth factors

Issue: 2018, Volume 69, Issue 5
Pages: 1173-1178
Publication date: 2018/6/15
https://doi.org/10.37358/RC.18.5.6283
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Creative Commons License
This article is published under the Creative Commons Attribution 4.0 International License
Citation Styles
Cite this article as:
PIRTEA, L., GRIGORAS, D., SECOSAN, C., SAS, I., ILINA, R., JITARIU, A.A., MEDERLE, O.A., Clinical and Histopathological Parameters Correlate with Microvessel Density but Not with Vascular Endothelial Growth Factor Expression in Ovarian Cancer, Rev. Chim., 69(5), 2018, 1173-1178.

Vancouver
Pirtea L, Grigoras D, Secosan C, Sas I, Ilina R, Jitariu AA, Mederle OA. Clinical and Histopathological Parameters Correlate with Microvessel Density but Not with Vascular Endothelial Growth Factor Expression in Ovarian Cancer. Rev. Chim.[internet]. 2018 May;69(5):1173-1178. Available from: https://doi.org/10.37358/RC.18.5.6283


APA 6th edition
Pirtea, L., Grigoras, D., Secosan, C., Sas, I., Ilina, R., Jitariu, A.A. & Mederle, O.A. (2018). Clinical and Histopathological Parameters Correlate with Microvessel Density but Not with Vascular Endothelial Growth Factor Expression in Ovarian Cancer. Revista de Chimie, 69(5), 1173-1178. https://doi.org/10.37358/RC.18.5.6283


Harvard
Pirtea, L., Grigoras, D., Secosan, C., Sas, I., Ilina, R., Jitariu, A.A., Mederle, O.A. (2018). 'Clinical and Histopathological Parameters Correlate with Microvessel Density but Not with Vascular Endothelial Growth Factor Expression in Ovarian Cancer', Revista de Chimie, 69(5), pp. 1173-1178. https://doi.org/10.37358/RC.18.5.6283


IEEE
L. Pirtea, D. Grigoras, C. Secosan, I. Sas, R. Ilina, A.A. Jitariu, O.A. Mederle, "Clinical and Histopathological Parameters Correlate with Microvessel Density but Not with Vascular Endothelial Growth Factor Expression in Ovarian Cancer". Revista de Chimie, vol. 69, no. 5, pp. 1173-1178, 2018. [online]. https://doi.org/10.37358/RC.18.5.6283


Text
Laurentiu Pirtea, Dorin Grigoras, Cristina Secosan, Ioan Sas, Razvan Ilina, Adriana Andreea Jitariu, Ovidiu Alexandru Mederle,
Clinical and Histopathological Parameters Correlate with Microvessel Density but Not with Vascular Endothelial Growth Factor Expression in Ovarian Cancer,
Revista de Chimie,
Volume 69, Issue 5,
2018,
Pages 1173-1178,
ISSN 2668-8212,
https://doi.org/10.37358/RC.18.5.6283.
(https://revistadechimie.ro/Articles.asp?ID=6283)
Keywords: VEGF; MVD; ovarian cancer; angiogenesis; growth factors


RIS
TY - JOUR
T1 - Clinical and Histopathological Parameters Correlate with Microvessel Density but Not with Vascular Endothelial Growth Factor Expression in Ovarian Cancer
A1 - Pirtea, Laurentiu
A2 - Grigoras, Dorin
A3 - Secosan, Cristina
A4 - Sas, Ioan
A5 - Ilina, Razvan
A6 - Jitariu, Adriana Andreea
A7 - Mederle, Ovidiu Alexandru
JF - Revista de Chimie
JO - Rev. Chim.
PB - Revista de Chimie SRL
SN - 2668-8212
Y1 - 2018
VL - 69
IS - 5
SP - 1173
EP - 1178
UR - https://doi.org/10.37358/RC.18.5.6283
KW - VEGF
KW - MVD
KW - ovarian cancer
KW - angiogenesis
KW - growth factors
ER -


BibTex
@article{RevCh2018P1173,
author = {Pirtea Laurentiu and Grigoras Dorin and Secosan Cristina and Sas Ioan and Ilina Razvan and Jitariu Adriana Andreea and Mederle Ovidiu Alexandru},
title = {Clinical and Histopathological Parameters Correlate with Microvessel Density but Not with Vascular Endothelial Growth Factor Expression in Ovarian Cancer},
journal = {Revista de Chimie},
volume = {69},
number = {5},
pages = {1173-1178},
year = {2018},
issn = {2668-8212},
doi = {https://doi.org/10.37358/RC.18.5.6283},
url = {https://revistadechimie.ro/Articles.asp?ID=6283}
}
 
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