AGRIPINA RASCU, OANA CRISTINA ARGHIR, EUGENIA NAGHI, MARINA RUXANDRA OTELEA SERUM AMINOTRANSFERASES AND THE SEVERITY OF ASTHMA The serum enzymes are ideal diagnostic or prediction markers. Aspartate aminotransferase (AST), a mitochondrial and cytoplasmic enzyme, is one of the well-known markers of hepatic, myocardial or skeletal muscle cytolysis, while alanine aminotransferase (ALT) is mainly a hepatic cytoplasmic enzyme. The normal plasmatic values of AST and of ALT reflect a physiological cell turnover. Therefore, both high and low levels of serum liver enzymes might have a clinical significance. We have conducted a retrospective study targeting the association between the serum AST and ALT levels and the lung function impairment among patients with occupational asthma but without hepatic, cardiac, renal or muscular disorders. Our data show a significant relation (R = 0.54, p <0.05) between the parameters of obstructive ventilator syndrome and AST and ALT levels, respectively (R =0.42, p <0.05). If this relation is confirmed in prospective studies, serum AST and ALT could become useful markers in monitoring asthma patients.