ANDREEA GHERASIM, PETRU CIANGA, ECATERINA ANISIE, LIDIA IULIANA ARHIRE, LAURA MIHALACHE, OTILIA NITA, RADU SEBASTIAN GAVRIL, MARIANA GRAUR EVALUATION OF SERUM VITAMIN B12 LEVELS IN TYPE 2 DIABETES PATIENTS METFORMIN TREATED Vitamin B12 deficiency is a condition characterized by neurological or haematological abnormalities, and may occur after treatment with metformin in patients with type 2 diabetes. We evaluated 119 patients with type 2 diabetes mellitus, treated with oral antidiabetic agents. The parameters evaluated were: vitamin B12 intake, anthropometric data, disease history, neuropathic complications evaluation (using MNSI), serum vitamin B12, glycated hemoglobin, erythrocyte indices. Vitamin B12 deficiency was defined at values below 194 pg/mL. We have found a prevalence of vitamin B12 deficiency of 13.9% in the patients treated with metformin (10.9% in all participants). B12 levels were not correlated with age, metformin dose or duration of treatment. Patients using B12 supplements had higher B12 serum levels (472.50 vs. 329.22, p £ 0.05).
Keywords: B12 deficiency, type 2 diabetes mellitus, metformin