Evaluation of Serum Vitamin B12 Levels in Type 2 Diabetes Patients Metformin Treated

Gherasim, Andreea; Cianga, Petru; Anisie, Ecaterina; Arhire, Lidia Iuliana; Mihalache, Laura; Nita, Otilia; Gavril, Radu Sebastian; Graur, Mariana

Andreea Gherasim, Petru Cianga, Ecaterina Anisie, Lidia Iuliana Arhire, Laura Mihalache, Otilia Nita, Radu Sebastian Gavril, Mariana Graur

Evaluation of Serum Vitamin B12 Levels in Type 2 Diabetes Patients Metformin Treated

Abstract:

Vitamin B12 deficiency is a condition characterized by neurological or haematological abnormalities, and may occur after treatment with metformin in patients with type 2 diabetes. We evaluated 119 patients with type 2 diabetes mellitus, treated with oral antidiabetic agents. The parameters evaluated were: vitamin B12 intake, anthropometric data, disease history, neuropathic complications evaluation (using MNSI), serum vitamin B12, glycated hemoglobin, erythrocyte indices. Vitamin B12 deficiency was defined at values below 194 pg/mL. We have found a prevalence of vitamin B12 deficiency of 13.9% in the patients treated with metformin (10.9% in all participants). B12 levels were not correlated with age, metformin dose or duration of treatment. Patients using B12 supplements had higher B12 serum levels (472.50 vs. 329.22, p £ 0.05).

Keywords:
B12 deficiency; type 2 diabetes mellitus; metformin

Issue: 2018, Volume 69, Issue 5

Pages: 1207-1211

Publication date: 2018/6/15

https://doi.org/10.37358/RC.18.5.6290

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This article is published under the Creative Commons Attribution 4.0 International License

Citation Styles

Cite this article as:
GHERASIM, A., CIANGA, P., ANISIE, E., ARHIRE, L.I., MIHALACHE, L., NITA, O., GAVRIL, R.S., GRAUR, M., Evaluation of Serum Vitamin B12 Levels in Type 2 Diabetes Patients Metformin Treated, Rev. Chim., 69(5), 2018, 1207-1211.

Vancouver
Gherasim A, Cianga P, Anisie E, Arhire LI, Mihalache L, Nita O, Gavril RS, Graur M. Evaluation of Serum Vitamin B12 Levels in Type 2 Diabetes Patients Metformin Treated. Rev. Chim.[internet]. 2018 May;69(5):1207-1211. Available from: https://doi.org/10.37358/RC.18.5.6290

APA 6th edition
Gherasim, A., Cianga, P., Anisie, E., Arhire, L.I., Mihalache, L., Nita, O., Gavril, R.S. & Graur, M. (2018). Evaluation of Serum Vitamin B12 Levels in Type 2 Diabetes Patients Metformin Treated. Revista de Chimie, 69(5), 1207-1211. https://doi.org/10.37358/RC.18.5.6290

Harvard
Gherasim, A., Cianga, P., Anisie, E., Arhire, L.I., Mihalache, L., Nita, O., Gavril, R.S., Graur, M. (2018). 'Evaluation of Serum Vitamin B12 Levels in Type 2 Diabetes Patients Metformin Treated', Revista de Chimie, 69(5), pp. 1207-1211. https://doi.org/10.37358/RC.18.5.6290

IEEE
A. Gherasim, P. Cianga, E. Anisie, L.I. Arhire, L. Mihalache, O. Nita, R.S. Gavril, M. Graur, "Evaluation of Serum Vitamin B12 Levels in Type 2 Diabetes Patients Metformin Treated". Revista de Chimie, vol. 69, no. 5, pp. 1207-1211, 2018. [online]. https://doi.org/10.37358/RC.18.5.6290

Text
Andreea Gherasim, Petru Cianga, Ecaterina Anisie, Lidia Iuliana Arhire, Laura Mihalache, Otilia Nita, Radu Sebastian Gavril, Mariana Graur,
Evaluation of Serum Vitamin B12 Levels in Type 2 Diabetes Patients Metformin Treated,
Revista de Chimie,
Volume 69, Issue 5,
2018,
Pages 1207-1211,
ISSN 2668-8212,
https://doi.org/10.37358/RC.18.5.6290.
(https://revistadechimie.ro/Articles.asp?ID=6290)
Keywords: B12 deficiency; type 2 diabetes mellitus; metformin

RIS
TY - JOUR
T1 - Evaluation of Serum Vitamin B12 Levels in Type 2 Diabetes Patients Metformin Treated
A1 - Gherasim, Andreea
A2 - Cianga, Petru
A3 - Anisie, Ecaterina
A4 - Arhire, Lidia Iuliana
A5 - Mihalache, Laura
A6 - Nita, Otilia
A7 - Gavril, Radu Sebastian
A8 - Graur, Mariana
JF - Revista de Chimie
JO - Rev. Chim.
PB - Revista de Chimie SRL
SN - 2668-8212
Y1 - 2018
VL - 69
IS - 5
SP - 1207
EP - 1211
UR - https://doi.org/10.37358/RC.18.5.6290
KW - B12 deficiency
KW - type 2 diabetes mellitus
KW - metformin
ER -

BibTex
@article{RevCh2018P1207,
author = {Gherasim Andreea and Cianga Petru and Anisie Ecaterina and Arhire Lidia Iuliana and Mihalache Laura and Nita Otilia and Gavril Radu Sebastian and Graur Mariana},
title = {Evaluation of Serum Vitamin B12 Levels in Type 2 Diabetes Patients Metformin Treated},
journal = {Revista de Chimie},
volume = {69},
number = {5},
pages = {1207-1211},
year = {2018},
issn = {2668-8212},
doi = {https://doi.org/10.37358/RC.18.5.6290},
url = {https://revistadechimie.ro/Articles.asp?ID=6290}
}

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