Collagen - Lidocaine Microcapsules with Controlled Release for Tooth Extraction Pain

Marin, Maria Minodora; Ignat, Madalina; Ghica, Mihaela Violeta; Kaya, Madalina Albu; Pirvu, Cristina Dinu; Anuta, Valentina; Popa, Lacramioara

Maria Minodora Marin, Madalina Ignat, Mihaela Violeta Ghica, Madalina Albu Kaya, Cristina Dinu Pirvu, Valentina Anuta, Lacramioara Popa

Collagen - Lidocaine Microcapsules with Controlled Release for Tooth Extraction Pain

Abstract:

The pain management is therefore of paramount importance and the local anesthetic treatment has to be considered. Thus, the purpose of this study was to design and characterize some collagen microcapsules incorporating an anesthetic. The collagen hydrolysate was prepared by spray-drying forming micro sizes spheres (microcapsules) which were loaded with 1% lidocaine (anesthetic) and cross-linked with different cross-linking agent: tannic acid, glutaraldehyde and genipin, in order to obtain solution for tooth pain. The wetting behavior of dried microcapsules powders was determined by contact angle measurement. The microcapsule solutions were characterized by dynamic light scattering (DLS) and in vitro release of lidocaine was investigated. These therapeutically products, based on collagen microcapsules, a local anesthetic and three cross-linking agents, could have potential biomedical application in tooth pain healing treatment.

Keywords:
Microcapsules; collagen; lidocaine; pain

Issue: 2018, Volume 69, Issue 5

Pages: 1213-1215

Publication date: 2018/6/15

https://doi.org/10.37358/RC.18.5.6291

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This article is published under the Creative Commons Attribution 4.0 International License

Citation Styles

Cite this article as:
MARIN, M.M., IGNAT, M., GHICA, M.V., KAYA, M.A., PIRVU, C.D., ANUTA, V., POPA, L., Collagen - Lidocaine Microcapsules with Controlled Release for Tooth Extraction Pain, Rev. Chim., 69(5), 2018, 1213-1215.

Vancouver
Marin MM, Ignat M, Ghica MV, Kaya MA, Pirvu CD, Anuta V, Popa L. Collagen - Lidocaine Microcapsules with Controlled Release for Tooth Extraction Pain. Rev. Chim.[internet]. 2018 May;69(5):1213-1215. Available from: https://doi.org/10.37358/RC.18.5.6291

APA 6th edition
Marin, M.M., Ignat, M., Ghica, M.V., Kaya, M.A., Pirvu, C.D., Anuta, V. & Popa, L. (2018). Collagen - Lidocaine Microcapsules with Controlled Release for Tooth Extraction Pain. Revista de Chimie, 69(5), 1213-1215. https://doi.org/10.37358/RC.18.5.6291

Harvard
Marin, M.M., Ignat, M., Ghica, M.V., Kaya, M.A., Pirvu, C.D., Anuta, V., Popa, L. (2018). 'Collagen - Lidocaine Microcapsules with Controlled Release for Tooth Extraction Pain', Revista de Chimie, 69(5), pp. 1213-1215. https://doi.org/10.37358/RC.18.5.6291

IEEE
M.M. Marin, M. Ignat, M.V. Ghica, M.A. Kaya, C.D. Pirvu, V. Anuta, L. Popa, "Collagen - Lidocaine Microcapsules with Controlled Release for Tooth Extraction Pain". Revista de Chimie, vol. 69, no. 5, pp. 1213-1215, 2018. [online]. https://doi.org/10.37358/RC.18.5.6291

Text
Maria Minodora Marin, Madalina Ignat, Mihaela Violeta Ghica, Madalina Albu Kaya, Cristina Dinu Pirvu, Valentina Anuta, Lacramioara Popa,
Collagen - Lidocaine Microcapsules with Controlled Release for Tooth Extraction Pain,
Revista de Chimie,
Volume 69, Issue 5,
2018,
Pages 1213-1215,
ISSN 2668-8212,
https://doi.org/10.37358/RC.18.5.6291.
(https://revistadechimie.ro/Articles.asp?ID=6291)
Keywords: Microcapsules; collagen; lidocaine; pain

RIS
TY - JOUR
T1 - Collagen - Lidocaine Microcapsules with Controlled Release for Tooth Extraction Pain
A1 - Marin, Maria Minodora
A2 - Ignat, Madalina
A3 - Ghica, Mihaela Violeta
A4 - Kaya, Madalina Albu
A5 - Pirvu, Cristina Dinu
A6 - Anuta, Valentina
A7 - Popa, Lacramioara
JF - Revista de Chimie
JO - Rev. Chim.
PB - Revista de Chimie SRL
SN - 2668-8212
Y1 - 2018
VL - 69
IS - 5
SP - 1213
EP - 1215
UR - https://doi.org/10.37358/RC.18.5.6291
KW - Microcapsules
KW - collagen
KW - lidocaine
KW - pain
ER -

BibTex
@article{RevCh2018P1213,
author = {Marin Maria Minodora and Ignat Madalina and Ghica Mihaela Violeta and Kaya Madalina Albu and Pirvu Cristina Dinu and Anuta Valentina and Popa Lacramioara},
title = {Collagen - Lidocaine Microcapsules with Controlled Release for Tooth Extraction Pain},
journal = {Revista de Chimie},
volume = {69},
number = {5},
pages = {1213-1215},
year = {2018},
issn = {2668-8212},
doi = {https://doi.org/10.37358/RC.18.5.6291},
url = {https://revistadechimie.ro/Articles.asp?ID=6291}
}

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