MARIA MINODORA MARIN, MADALINA IGNAT, MIHAELA VIOLETA GHICA, MADALINA ALBU KAYA, CRISTINA DINU PIRVU, VALENTINA ANUTA, LACRAMIOARA POPA COLLAGEN - LIDOCAINE MICROCAPSULES WITH CONTROLLED RELEASE FOR TOOTH EXTRACTION PAIN The pain management is therefore of paramount importance and the local anesthetic treatment has to be considered. Thus, the purpose of this study was to design and characterize some collagen microcapsules incorporating an anesthetic. The collagen hydrolysate was prepared by spray-drying forming micro sizes spheres (microcapsules) which were loaded with 1% lidocaine (anesthetic) and cross-linked with different cross-linking agent: tannic acid, glutaraldehyde and genipin, in order to obtain solution for tooth pain. The wetting behavior of dried microcapsules powders was determined by contact angle measurement. The microcapsule solutions were characterized by dynamic light scattering (DLS) and in vitro release of lidocaine was investigated. These therapeutically products, based on collagen microcapsules, a local anesthetic and three cross-linking agents, could have potential biomedical application in tooth pain healing treatment.