In Vivo Pilot Study Regarding the Effects of Amoxicillin on Blood Glucose Levels, Body Weight and Water Intake

Mihalas, Eugeniu; Balan, Adriana; Petcu (Sirghe), Ana; Gavrila, Laura; Savin, Carmen

Eugeniu Mihalas, Adriana Balan, Ana Petcu (Sirghe), Laura Gavrila, Carmen Savin

In Vivo Pilot Study Regarding the Effects of Amoxicillin on Blood Glucose Levels, Body Weight and Water Intake

Abstract:

Amoxicillin it is the most commonly prescribed antibiotic agent and the first intention in the short-term treatment of infections in children. The aim of this study was to assess the effects of amoxicillin/clavulanic acid (AMC) chronic administration on the laboratory mice’s body weight (BW), water intake and values of non-fasting blood glucose levels (n-FBG). Thus, twenty-eight C57BL/6 male mice, of similar age, randomly divided into a control and 3 treatment groups (n = 7) received subcutaneous injection, once per day, for 60 days. During the experiment the n-FBG, daily water intake, and BW changes were recorded every 10 days. The results of our study revealed that the chronic administration of AMC, at a concentration of 100 and 150 mg/kg BW/day, increased capillary n-FGB, and can be associated with a significant increase in the BW and daily water intake in mice.

Keywords:
mice; amoxicillin; clavulanic acid; blood glucose; water intake; body weight

Issue: 2018, Volume 69, Issue 5

Pages: 1229-1232

Publication date: 2018/6/15

https://doi.org/10.37358/RC.18.5.6296

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This article is published under the Creative Commons Attribution 4.0 International License

Citation Styles

Cite this article as:
MIHALAS, E., BALAN, A., PETCU (SIRGHE), A., GAVRILA, L., SAVIN, C., In Vivo Pilot Study Regarding the Effects of Amoxicillin on Blood Glucose Levels, Body Weight and Water Intake, Rev. Chim., 69(5), 2018, 1229-1232.

Vancouver
Mihalas E, Balan A, Petcu (Sirghe) A, Gavrila L, Savin C. In Vivo Pilot Study Regarding the Effects of Amoxicillin on Blood Glucose Levels, Body Weight and Water Intake. Rev. Chim.[internet]. 2018 May;69(5):1229-1232. Available from: https://doi.org/10.37358/RC.18.5.6296

APA 6th edition
Mihalas, E., Balan, A., Petcu (Sirghe), A., Gavrila, L. & Savin, C. (2018). In Vivo Pilot Study Regarding the Effects of Amoxicillin on Blood Glucose Levels, Body Weight and Water Intake. Revista de Chimie, 69(5), 1229-1232. https://doi.org/10.37358/RC.18.5.6296

Harvard
Mihalas, E., Balan, A., Petcu (Sirghe), A., Gavrila, L., Savin, C. (2018). 'In Vivo Pilot Study Regarding the Effects of Amoxicillin on Blood Glucose Levels, Body Weight and Water Intake', Revista de Chimie, 69(5), pp. 1229-1232. https://doi.org/10.37358/RC.18.5.6296

IEEE
E. Mihalas, A. Balan, A. Petcu(Sirghe), L. Gavrila, C. Savin, "In Vivo Pilot Study Regarding the Effects of Amoxicillin on Blood Glucose Levels, Body Weight and Water Intake". Revista de Chimie, vol. 69, no. 5, pp. 1229-1232, 2018. [online]. https://doi.org/10.37358/RC.18.5.6296

Text
Eugeniu Mihalas, Adriana Balan, Ana Petcu(Sirghe), Laura Gavrila, Carmen Savin,
In Vivo Pilot Study Regarding the Effects of Amoxicillin on Blood Glucose Levels, Body Weight and Water Intake,
Revista de Chimie,
Volume 69, Issue 5,
2018,
Pages 1229-1232,
ISSN 2668-8212,
https://doi.org/10.37358/RC.18.5.6296.
(https://revistadechimie.ro/Articles.asp?ID=6296)
Keywords: mice; amoxicillin; clavulanic acid; blood glucose; water intake; body weight

RIS
TY - JOUR
T1 - In Vivo Pilot Study Regarding the Effects of Amoxicillin on Blood Glucose Levels, Body Weight and Water Intake
A1 - Mihalas, Eugeniu
A2 - Balan, Adriana
A3 - Petcu (Sirghe), Ana
A4 - Gavrila, Laura
A5 - Savin, Carmen
JF - Revista de Chimie
JO - Rev. Chim.
PB - Revista de Chimie SRL
SN - 2668-8212
Y1 - 2018
VL - 69
IS - 5
SP - 1229
EP - 1232
UR - https://doi.org/10.37358/RC.18.5.6296
KW - mice
KW - amoxicillin
KW - clavulanic acid
KW - blood glucose
KW - water intake
KW - body weight
ER -

BibTex
@article{RevCh2018P1229,
author = {Mihalas Eugeniu and Balan Adriana and Petcu (Sirghe) Ana and Gavrila Laura and Savin Carmen},
title = {In Vivo Pilot Study Regarding the Effects of Amoxicillin on Blood Glucose Levels, Body Weight and Water Intake},
journal = {Revista de Chimie},
volume = {69},
number = {5},
pages = {1229-1232},
year = {2018},
issn = {2668-8212},
doi = {https://doi.org/10.37358/RC.18.5.6296},
url = {https://revistadechimie.ro/Articles.asp?ID=6296}
}

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