The Role of Combining Biochemical Markers in Assessing the Endoscopic Activity in Ulcerative Colitis

Dranga, Mihaela; Mihai, Catalina; Gavrilescu, Otilia; Cardoneanu, Anca; Floria, Mariana; Mihai, Bogdan; Prelipcean, Cristina Cijevschi

Mihaela Dranga, Catalina Mihai, Otilia Gavrilescu, Anca Cardoneanu, Mariana Floria, Bogdan Mihai, Cristina Cijevschi Prelipcean

The Role of Combining Biochemical Markers in Assessing the Endoscopic Activity in Ulcerative Colitis

Abstract:

Ulcerative colitis (UC) isa chronic, idiopathic and recurrent inflammatory bowel disease (IBD), characterized by periods of activity and remissionwhose monitoring requires invasive explorations associated with discomfort for the patient and important costs. Mucosal healing became one of the most important therapeutic targets in UC. The aim of our study was to identify a score, made up of noninvasive, available, used in current clinical practice biochemical markers, which should correlate with endoscopic activity in UC. We conducted a prospective study on 114 patients with UC. All patients were assessed both for biological inflammatory markers: erythrocyte sedimentation rate (ESR),C- reactive protein (CRP), fibrinogen, platelets, albumin, fecal calprotectin (FC) and by colonoscopy to estimate the endoscopic activity using Mayo score. By linear regression, we tried to identify a biochemical score correlated with endoscopic activity. Out of the serological markers,ESR (p=0.014), CRP(p= 0.021) and fibrinogen (p=0.035) correlated with the endoscopic activity of the disease. The best sensitivity to determine the endoscopic activity was given by FC (96.05%) with a predictable negative value of 91.1% (p=0.001). The score determined by linear regression: 1 (ESR]15mm/1h) x 0.305 + 1(fibrinogen]340.5mg/dL) x 0.309+1 (CRP] 5 mg/L) + 1 (calprotectin]200 μg/g) had an increased positive predictive value compared to each and one biomarker, nevertheless, with a sensitivity and specificity inferior to that of FC. Up to now, it is the first attempt to achieve a score made up exclusively of biological markers. The obtained score, although with an increased accuracy, has proven to have a lower predictability in comparison with FC used individually and cannot entirely replace colonoscopy.

Keywords:
inflammatory biomarkers; score; fecal calprotectin; ulcerative colitis; Mayo score

Issue: 2018, Volume 69, Issue 5

Pages: 1268-1271

Publication date: 2018/6/15

https://doi.org/10.37358/RC.18.5.6305

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This article is published under the Creative Commons Attribution 4.0 International License

Citation Styles

Cite this article as:
DRANGA, M., MIHAI, C., GAVRILESCU, O., CARDONEANU, A., FLORIA, M., MIHAI, B., PRELIPCEAN, C.C., The Role of Combining Biochemical Markers in Assessing the Endoscopic Activity in Ulcerative Colitis, Rev. Chim., 69(5), 2018, 1268-1271.

Vancouver
Dranga M, Mihai C, Gavrilescu O, Cardoneanu A, Floria M, Mihai B, Prelipcean CC. The Role of Combining Biochemical Markers in Assessing the Endoscopic Activity in Ulcerative Colitis. Rev. Chim.[internet]. 2018 May;69(5):1268-1271. Available from: https://doi.org/10.37358/RC.18.5.6305

APA 6th edition
Dranga, M., Mihai, C., Gavrilescu, O., Cardoneanu, A., Floria, M., Mihai, B. & Prelipcean, C.C. (2018). The Role of Combining Biochemical Markers in Assessing the Endoscopic Activity in Ulcerative Colitis. Revista de Chimie, 69(5), 1268-1271. https://doi.org/10.37358/RC.18.5.6305

Harvard
Dranga, M., Mihai, C., Gavrilescu, O., Cardoneanu, A., Floria, M., Mihai, B., Prelipcean, C.C. (2018). 'The Role of Combining Biochemical Markers in Assessing the Endoscopic Activity in Ulcerative Colitis', Revista de Chimie, 69(5), pp. 1268-1271. https://doi.org/10.37358/RC.18.5.6305

IEEE
M. Dranga, C. Mihai, O. Gavrilescu, A. Cardoneanu, M. Floria, B. Mihai, C.C. Prelipcean, "The Role of Combining Biochemical Markers in Assessing the Endoscopic Activity in Ulcerative Colitis". Revista de Chimie, vol. 69, no. 5, pp. 1268-1271, 2018. [online]. https://doi.org/10.37358/RC.18.5.6305

Text
Mihaela Dranga, Catalina Mihai, Otilia Gavrilescu, Anca Cardoneanu, Mariana Floria, Bogdan Mihai, Cristina Cijevschi Prelipcean,
The Role of Combining Biochemical Markers in Assessing the Endoscopic Activity in Ulcerative Colitis,
Revista de Chimie,
Volume 69, Issue 5,
2018,
Pages 1268-1271,
ISSN 2668-8212,
https://doi.org/10.37358/RC.18.5.6305.
(https://revistadechimie.ro/Articles.asp?ID=6305)
Keywords: inflammatory biomarkers; score; fecal calprotectin; ulcerative colitis; Mayo score

RIS
TY - JOUR
T1 - The Role of Combining Biochemical Markers in Assessing the Endoscopic Activity in Ulcerative Colitis
A1 - Dranga, Mihaela
A2 - Mihai, Catalina
A3 - Gavrilescu, Otilia
A4 - Cardoneanu, Anca
A5 - Floria, Mariana
A6 - Mihai, Bogdan
A7 - Prelipcean, Cristina Cijevschi
JF - Revista de Chimie
JO - Rev. Chim.
PB - Revista de Chimie SRL
SN - 2668-8212
Y1 - 2018
VL - 69
IS - 5
SP - 1268
EP - 1271
UR - https://doi.org/10.37358/RC.18.5.6305
KW - inflammatory biomarkers
KW - score
KW - fecal calprotectin
KW - ulcerative colitis
KW - Mayo score
ER -

BibTex
@article{RevCh2018P1268,
author = {Dranga Mihaela and Mihai Catalina and Gavrilescu Otilia and Cardoneanu Anca and Floria Mariana and Mihai Bogdan and Prelipcean Cristina Cijevschi},
title = {The Role of Combining Biochemical Markers in Assessing the Endoscopic Activity in Ulcerative Colitis},
journal = {Revista de Chimie},
volume = {69},
number = {5},
pages = {1268-1271},
year = {2018},
issn = {2668-8212},
doi = {https://doi.org/10.37358/RC.18.5.6305},
url = {https://revistadechimie.ro/Articles.asp?ID=6305}
}

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