MARIUS DABIJA, OTILIA BOISTEANU, VICTOR DOROBAT, RALUCA DARGOMIR, VIOREL IBRIC, VICTOR VLAD COSTAN RECONSTRUCTION OF SKULL AND SKULL BASE DEFECTS USING TITANIUM, COLLAGEN, POLYESTERURETHANE AND OTHER ALLOPLASTIC, ALLOGENEIC, XENOGENEIC AND AUTOGENIC MATERIALS We present our experience in the reconstruction of 12 defects of the skull and lateral skull base following the resection of advanced stage malignant tumors. The reconstruction was performed using three pectoralis major flaps and six temporalis muscle flaps, local skin flaps in two cases and one skin graft. For three dural defects, the plasty was performed using synthetic substitutes. In two cases titanium mesh was utilized for protection of the soft tissues. In one patient a gold plate was used to counteract the effects of facial nerve paralysis on eyelid closure. The advantages and disadvantages of the reconstructive methods are discussed, together with a literature review listing frequently used methods of skull base defect restoration, including autogenous tissues in the form of local, regional or distant flaps, as well as allogeneic, xenogeneic and alloplastic materials.