OVIDIU MIHAIL STEFANESCU, RALUCA DRAGOMIR, OANAELENA CIURCANU, CRISTIAN CONSTANTIN BUDACU RISK FACTORS AND THE MECHANISM OF INDUCED ORAL CANCER BY THE CHEMICAL SUBSTANCES At this end of the millennium we witness an impressive increase in cancer frequency. According to WHO reports, cancer is the second cause of death, being overpriced by cardiovascular disease only. The oral cavity cancer is part of the ENT sphere malignant tumor group. It may appear at the level of any component structure: mobile tongue, mouth floor, retromolar trine (behind the last molar teeth in the lower arch), tough palate, internal cheek, lips, mouth vestibule or alveolar rebord. Salivary glands, although opening into the oral cavity, can not be included in this category, due to histological and enlargement features. Oral cancer is very easy to be noted because it causes a mouthstroke that does not heal over several weeks. This is the main symptom of the disease, but not the only one. Other signs are: whitish spots in the mouth, unexplained bleeding, difficulty in moving the jaw or chewing; hoarseness or considerable change in voice, loss of sensation or pain in the mouth, face or neck area, undue ear pain. The study includes 544 cases, and the statistical data collected over a 5-year period, 2013-2017, and: age, environment, sex, risk factors involved, location, tumor study and treatment are of interest. Combined therapy was reserved for patients with a low healing rate. The most common form of treatment was tumor removal within the limits of tumor safety, followed by another type of intervention: tumor extirpation and ganglion recording, whether or not associated with radiotherapy. An important role is also played by patients who come late, either due to a lack of health education or because of the fear of illness, or in most cases due to the oligosymptomatic character of the disease at the onset of onset.