ANDREEA GABRIELA MOCANU, ADINA TURCU STIOLICA, IONELA BELU, MARIA VIORICA CIOCILTEU, VALENTIN COSTEL MANDA, CLAUDIU NICOLICESCU, JOHNY NEAMTU QUALITY BY DESIGN FOR CIPROFLOXACIN ENCAPSULATION IN PLGA FACTORS ASSESSMENT FOLLOWED BY SCREENING AND OPTIMIZATION The objective of this study is to formulate and characterize ciprofloxacin-PLGA nanoparticles in laboratory. Ciprofloxacin-PLGA nanoparticles were obtained with Ciprofloxacin and PLGA as raw materials at the room temperature. The optimum set of process parameters were determined using Design of Experiments (DoE) with the factors: PLGA concentration, Ciprofloxacin concentration, Agitation Rate and the responses: Particles Size, Ciprofloxacin Encapsulation. The optimized formulation had 36.83% Ciprofloxacin Encapsulation and 87.58nm Particles Size in the conditions of 10% PLGA Concentration, 24.8 mg Ciprofloxacin Concentration and 1500 Rpm.
Keywords: Design of Experiments, Ciprofloxacin, PLGA