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REVISTA DE CHIMIE
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https://doi.org/10.37358/Rev.Chim.1949

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Revista de Chimie (Rev. Chim.), Year 2018, Volume 69, Issue 6, 1441-1446

https://doi.org/10.37358/RC.18.6.6342

Mariana Cornelia Tilinca, Tudor Sorin Pop, Orsolya Zsuzsa Szasz, Stefan Barbu, Kinga Nyulas, Eniko Nemes Nagy

Dynamics of Metabolic and Inflammatory Parameters in Overweight Patients Undergoing Knee or hip Arthroplasty

Abstract:

Osteoarthritis is a common problem in overweight and obese individuals and may lead to severe forms located especially at the knee and hip joints. Arthroplasty in these cases represents the appropriate treatment to solve the pain and to improve joint mobility. This intervention influences the laboratory parameters in different ways. The aim of the study was to compare pre- and postoperative values of metabolic and inflammatory parameters related to joint replacement surgery in patients suffering from advanced stages of knee and hip osteoarthritis, and to assess the relationship between different laboratory findings, taking into consideration the main cardio-metabolic comorbidities. The study was conducted at the Clinic of Orthopaedics and Traumatology of the Clinical County Hospital Mures between 2016-2017 on 57 overweight patients having severe knee or hip osteoarthritis undergoing total knee or hip arthroplasty. Plasma metabolic tests (uricemia, glycemia, triglycerides, cholesterol) and inflammatory markers (fibrinogen, high sensitive C-reactive protein - hsCRP) were followed in the studied overweight patients in the morning just before arthroplasty and 24 h after surgery. Dynamics of the measured laboratory tests and the relationship between them were assessed. Body mass index, waist circumference and cardio-metabolic associated diseases have also been evaluated. Significant decrease of uricemia, cholesterolemia, plasma triglyceride concentration and significant increase of hsCRP could be observed after joint replacement surgery compared to the previous values measured before the intervention. Glycemia was slightly higher after the arthroplasty, but the difference is not quite significant. Negative correlation could be found between preoperative HDL-cholesterol and plasma triglyceride level, while triglyceride concentration showed positive correlation with LDL-cholesterol and uricemia. BMI showed positive correlation with postoperative fibrinogen values. Hypertension was the most frequent cardio-metabolic comorbidity in the studied group. Significant difference occured in the level of a sensitive inflammatory marker and several biochemical laboratory tests suffered notable changes before and after arthroplasty in the studied group. Metabolic status was deeply affected by such an intervention during the first day after surgery. Laboratory components of the metabolic syndrome were present in close relationship in several patients. Further studies need to be performed for the dynamic assessment of more complex metabolic and inflammatory parameters in patients with similar pathology in order to evaluate the postoperative evolution and to provide appropriate support for these patients in the recovery process.
Keywords:
arthroplasty; overweight; inflammation; metabolism

Issue: 2018, Volume 69, Issue 6
Pages: 1441-1446
Publication date: 2018/7/15
https://doi.org/10.37358/RC.18.6.6342
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Creative Commons License
This article is published under the Creative Commons Attribution 4.0 International License
Citation Styles
Cite this article as:
TILINCA, M.C., POP, T.S., SZASZ, O.Z., BARBU, S., NYULAS, K., NAGY, E.N., Dynamics of Metabolic and Inflammatory Parameters in Overweight Patients Undergoing Knee or hip Arthroplasty, Rev. Chim., 69(6), 2018, 1441-1446.

Vancouver
Tilinca MC, Pop TS, Szasz OZ, Barbu S, Nyulas K, Nagy EN. Dynamics of Metabolic and Inflammatory Parameters in Overweight Patients Undergoing Knee or hip Arthroplasty. Rev. Chim.[internet]. 2018 Jun;69(6):1441-1446. Available from: https://doi.org/10.37358/RC.18.6.6342


APA 6th edition
Tilinca, M.C., Pop, T.S., Szasz, O.Z., Barbu, S., Nyulas, K. & Nagy, E.N. (2018). Dynamics of Metabolic and Inflammatory Parameters in Overweight Patients Undergoing Knee or hip Arthroplasty. Revista de Chimie, 69(6), 1441-1446. https://doi.org/10.37358/RC.18.6.6342


Harvard
Tilinca, M.C., Pop, T.S., Szasz, O.Z., Barbu, S., Nyulas, K., Nagy, E.N. (2018). 'Dynamics of Metabolic and Inflammatory Parameters in Overweight Patients Undergoing Knee or hip Arthroplasty', Revista de Chimie, 69(6), pp. 1441-1446. https://doi.org/10.37358/RC.18.6.6342


IEEE
M.C. Tilinca, T.S. Pop, O.Z. Szasz, S. Barbu, K. Nyulas, E.N. Nagy, "Dynamics of Metabolic and Inflammatory Parameters in Overweight Patients Undergoing Knee or hip Arthroplasty". Revista de Chimie, vol. 69, no. 6, pp. 1441-1446, 2018. [online]. https://doi.org/10.37358/RC.18.6.6342


Text
Mariana Cornelia Tilinca, Tudor Sorin Pop, Orsolya Zsuzsa Szasz, Stefan Barbu, Kinga Nyulas, Eniko Nemes Nagy,
Dynamics of Metabolic and Inflammatory Parameters in Overweight Patients Undergoing Knee or hip Arthroplasty,
Revista de Chimie,
Volume 69, Issue 6,
2018,
Pages 1441-1446,
ISSN 2668-8212,
https://doi.org/10.37358/RC.18.6.6342.
(https://revistadechimie.ro/Articles.asp?ID=6342)
Keywords: arthroplasty; overweight; inflammation; metabolism


RIS
TY - JOUR
T1 - Dynamics of Metabolic and Inflammatory Parameters in Overweight Patients Undergoing Knee or hip Arthroplasty
A1 - Tilinca, Mariana Cornelia
A2 - Pop, Tudor Sorin
A3 - Szasz, Orsolya Zsuzsa
A4 - Barbu, Stefan
A5 - Nyulas, Kinga
A6 - Nagy, Eniko Nemes
JF - Revista de Chimie
JO - Rev. Chim.
PB - Revista de Chimie SRL
SN - 2668-8212
Y1 - 2018
VL - 69
IS - 6
SP - 1441
EP - 1446
UR - https://doi.org/10.37358/RC.18.6.6342
KW - arthroplasty
KW - overweight
KW - inflammation
KW - metabolism
ER -


BibTex
@article{RevCh2018P1441,
author = {Tilinca Mariana Cornelia and Pop Tudor Sorin and Szasz Orsolya Zsuzsa and Barbu Stefan and Nyulas Kinga and Nagy Eniko Nemes},
title = {Dynamics of Metabolic and Inflammatory Parameters in Overweight Patients Undergoing Knee or hip Arthroplasty},
journal = {Revista de Chimie},
volume = {69},
number = {6},
pages = {1441-1446},
year = {2018},
issn = {2668-8212},
doi = {https://doi.org/10.37358/RC.18.6.6342},
url = {https://revistadechimie.ro/Articles.asp?ID=6342}
}
 
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