Beneficial Effects of Acetaminophen on the Chemical Mediators Involved in the Closure of Patent Ductus Arteriosus

Cinteza, Eliza; Ungureanu, Anda; Balgradean, Mihaela; Nicolescu, Alin

Eliza Cinteza, Anda Ungureanu, Mihaela Balgradean, Alin Nicolescu

Beneficial Effects of Acetaminophen on the Chemical Mediators Involved in the Closure of Patent Ductus Arteriosus

Abstract:

Paracetamol (N-acetyl- para-aminophenol) also known as acetaminophen is a chemical compound used in medical practice for analgesic and antipyretic effects. The mechanism of action is related to the cyclooxygenase (COX) activity, which is not full inhibit as for nonsteroidal anti-inflammatory. Paracetamol selectively inhibits COX activities in the brain, indirectly by reducing COX, which must be oxidized in order to function. In addition to analgesic and antipyretic effects, modulating the prostaglandin synthesis by selective inhibition of COX, a vascular modulator effect was described recently on the closure of the patent ductus arteriosus (PDA). This effect has been described in premature newborns, perhaps by decreasing the prostaglandin production. We present the case of a neonate, 39 weeks gestational age, normal birth weight who presented in the 10 th day of life with a cardiac murmur. Echocardiography evidenced a hemodynamically significant PDA, left ventricular enlargement, severe mitral regurgitation, patent foramen ovale and pulmonary hypertension. Although she was a 10-day- old full-term neonate paracetamol administration was attempted. Paracetamol was administered orally in the therapeutic dose of 15 mg/kg/dose, three times a day for three days. The effect was significant by reducing the diameter of the arterial duct (~50% of initial diameter), reducing the size of the left cardiac chambers, reducing the degree of mitral regurgitation from severe to mild, and disappearance of pulmonary hypertension. In conclusion, paracetamol use can change prognosis through the vaso-modulator on the PDA, at the age of 10 days, on a full-term neonate with a normal birth weight. This effect may also be present in full-term newborns and not only in preterm. Even if the PDA was not closed after three days, the hemodynamic impact disappeared and the child could avoid surgical ligation.

Keywords:
paracetamol; patent ductus arteriosus; heart failure; pulmonary hypertension;severe mitral regurgitation

Issue: 2018, Volume 69, Issue 6

Pages: 1537-1540

Publication date: 2018/7/15

https://doi.org/10.37358/RC.18.6.6363

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This article is published under the Creative Commons Attribution 4.0 International License

Citation Styles

Cite this article as:
CINTEZA, E., UNGUREANU, A., BALGRADEAN, M., NICOLESCU, A., Beneficial Effects of Acetaminophen on the Chemical Mediators Involved in the Closure of Patent Ductus Arteriosus, Rev. Chim., 69(6), 2018, 1537-1540.

Vancouver
Cinteza E, Ungureanu A, Balgradean M, Nicolescu A. Beneficial Effects of Acetaminophen on the Chemical Mediators Involved in the Closure of Patent Ductus Arteriosus. Rev. Chim.[internet]. 2018 Jun;69(6):1537-1540. Available from: https://doi.org/10.37358/RC.18.6.6363

APA 6th edition
Cinteza, E., Ungureanu, A., Balgradean, M. & Nicolescu, A. (2018). Beneficial Effects of Acetaminophen on the Chemical Mediators Involved in the Closure of Patent Ductus Arteriosus. Revista de Chimie, 69(6), 1537-1540. https://doi.org/10.37358/RC.18.6.6363

Harvard
Cinteza, E., Ungureanu, A., Balgradean, M., Nicolescu, A. (2018). 'Beneficial Effects of Acetaminophen on the Chemical Mediators Involved in the Closure of Patent Ductus Arteriosus', Revista de Chimie, 69(6), pp. 1537-1540. https://doi.org/10.37358/RC.18.6.6363

IEEE
E. Cinteza, A. Ungureanu, M. Balgradean, A. Nicolescu, "Beneficial Effects of Acetaminophen on the Chemical Mediators Involved in the Closure of Patent Ductus Arteriosus". Revista de Chimie, vol. 69, no. 6, pp. 1537-1540, 2018. [online]. https://doi.org/10.37358/RC.18.6.6363

Text
Eliza Cinteza, Anda Ungureanu, Mihaela Balgradean, Alin Nicolescu,
Beneficial Effects of Acetaminophen on the Chemical Mediators Involved in the Closure of Patent Ductus Arteriosus,
Revista de Chimie,
Volume 69, Issue 6,
2018,
Pages 1537-1540,
ISSN 2668-8212,
https://doi.org/10.37358/RC.18.6.6363.
(https://revistadechimie.ro/Articles.asp?ID=6363)
Keywords: paracetamol; patent ductus arteriosus; heart failure; pulmonary hypertension;severe mitral regurgitation

RIS
TY - JOUR
T1 - Beneficial Effects of Acetaminophen on the Chemical Mediators Involved in the Closure of Patent Ductus Arteriosus
A1 - Cinteza, Eliza
A2 - Ungureanu, Anda
A3 - Balgradean, Mihaela
A4 - Nicolescu, Alin
JF - Revista de Chimie
JO - Rev. Chim.
PB - Revista de Chimie SRL
SN - 2668-8212
Y1 - 2018
VL - 69
IS - 6
SP - 1537
EP - 1540
UR - https://doi.org/10.37358/RC.18.6.6363
KW - paracetamol
KW - patent ductus arteriosus
KW - heart failure
KW - pulmonary hypertension
KW - severe mitral regurgitation
ER -

BibTex
@article{RevCh2018P1537,
author = {Cinteza Eliza and Ungureanu Anda and Balgradean Mihaela and Nicolescu Alin},
title = {Beneficial Effects of Acetaminophen on the Chemical Mediators Involved in the Closure of Patent Ductus Arteriosus},
journal = {Revista de Chimie},
volume = {69},
number = {6},
pages = {1537-1540},
year = {2018},
issn = {2668-8212},
doi = {https://doi.org/10.37358/RC.18.6.6363},
url = {https://revistadechimie.ro/Articles.asp?ID=6363}
}

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