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REVISTA DE CHIMIE
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https://doi.org/10.37358/Rev.Chim.1949

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Revista de Chimie (Rev. Chim.), Year 2018, Volume 69, Issue 7, 1744-1748

https://doi.org/10.37358/RC.18.7.6408

Rashad Dmour, Liliana Mititelu Tartau, Allia Sindilar, Sorin Aurelian Pasca, Alin Horatiu Nedelcu, Dragos Valentin Crauciuc, Cristian Ilie Drochioi, Raluca Ecaterina Haliga, Loredana Hilitanu, Alin Constantin Pinzariu, Roxana Gabriela Cobzaru, Catalina Elena Lupusoru, Raoul Vasile Lupusoru

Experimental Researches on the Effects of Some Antibiotics on Carrageenan-induced Rat Paw Inflamation

Abstract:

The aim of our study was to evaluate the effects of some antibiotics on hepatic and renal integrity in rats with acute paw inflammation. Acute inflammation was induced after sub-plantar administration of carrageenan in rats. The substances: prednisone (PDN), indomethacin (IND), cefotaxime (CEF), gentamicin (GEN) and sulfamethoxazole (SMT) were injected intraperitoneally, 30 min before carrageenan administration. Saline was intra-paw administered in control group. Prednisone and indomethacin were injected in a single daily dose, and the antibiotics every 12 hours, during 3 days. Specific biochemical parameters, liver and kidney tissues were examined after 3, 24 and 72 hours. Experimental protocol was conducted according to the recommendation of our University Committee for Research and Ethical Issues. The use of GEN, SMT and CEF resulted in exacerbation of hepatic enzymes activity, increasing in serum creatinine, blood urea and uric acid levels, statistically significant comparing with control group. Histopathological examination revealed the alteration of liver and kidney architecture in groups treated with GEN and SMT. The effects of GEN were more accentuated than those of SMT and CEF. The treatment with GEN and SMT manifested hepatic and renal toxicity in rats with experimental carrageenan-induced acute paw inflammation.
Keywords:
cefotaxime; gentamicin; sulfamethoxazole; hepatic; real; toxicity

Issue: 2018, Volume 69, Issue 7
Pages: 1744-1748
Publication date: 2018/8/15
https://doi.org/10.37358/RC.18.7.6408
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Creative Commons License
This article is published under the Creative Commons Attribution 4.0 International License
Citation Styles
Cite this article as:
DMOUR, R., TARTAU, L.M., SINDILAR, A., PASCA, S.A., NEDELCU, A.H., CRAUCIUC, D.V., DROCHIOI, C.I., HALIGA, R.E., HILITANU, L., PINZARIU, A.C., COBZARU, R.G., LUPUSORU, C.E., LUPUSORU, R.V., Experimental Researches on the Effects of Some Antibiotics on Carrageenan-induced Rat Paw Inflamation, Rev. Chim., 69(7), 2018, 1744-1748.

Vancouver
Dmour R, Tartau LM, Sindilar A, Pasca SA, Nedelcu AH, Crauciuc DV, Drochioi CI, Haliga RE, Hilitanu L, Pinzariu AC, Cobzaru RG, Lupusoru CE, Lupusoru RV. Experimental Researches on the Effects of Some Antibiotics on Carrageenan-induced Rat Paw Inflamation. Rev. Chim.[internet]. 2018 Jul;69(7):1744-1748. Available from: https://doi.org/10.37358/RC.18.7.6408


APA 6th edition
Dmour, R., Tartau, L.M., Sindilar, A., Pasca, S.A., Nedelcu, A.H., Crauciuc, D.V.,... Lupusoru, R.V. (2018). Experimental Researches on the Effects of Some Antibiotics on Carrageenan-induced Rat Paw Inflamation. Revista de Chimie, 69(7), 1744-1748. https://doi.org/10.37358/RC.18.7.6408


Harvard
Dmour, R., Tartau, L.M., Sindilar, A., Pasca, S.A., Nedelcu, A.H., Crauciuc, D.V., Drochioi, C.I., Haliga, R.E., Hilitanu, L., Pinzariu, A.C., Cobzaru, R.G., Lupusoru, C.E., Lupusoru, R.V. (2018). 'Experimental Researches on the Effects of Some Antibiotics on Carrageenan-induced Rat Paw Inflamation', Revista de Chimie, 69(7), pp. 1744-1748. https://doi.org/10.37358/RC.18.7.6408


IEEE
R. Dmour, L.M. Tartau, A. Sindilar, S.A. Pasca, A.H. Nedelcu, D.V. Crauciuc, C.I. Drochioi, R.E. Haliga, L. Hilitanu, A.C. Pinzariu, R.G. Cobzaru, C.E. Lupusoru, R.V. Lupusoru, "Experimental Researches on the Effects of Some Antibiotics on Carrageenan-induced Rat Paw Inflamation". Revista de Chimie, vol. 69, no. 7, pp. 1744-1748, 2018. [online]. https://doi.org/10.37358/RC.18.7.6408


Text
Rashad Dmour, Liliana Mititelu Tartau, Allia Sindilar, Sorin Aurelian Pasca, Alin Horatiu Nedelcu, Dragos Valentin Crauciuc, Cristian Ilie Drochioi, Raluca Ecaterina Haliga, Loredana Hilitanu, Alin Constantin Pinzariu, Roxana Gabriela Cobzaru, Catalina Elena Lupusoru, Raoul Vasile Lupusoru,
Experimental Researches on the Effects of Some Antibiotics on Carrageenan-induced Rat Paw Inflamation,
Revista de Chimie,
Volume 69, Issue 7,
2018,
Pages 1744-1748,
ISSN 2668-8212,
https://doi.org/10.37358/RC.18.7.6408.
(https://revistadechimie.ro/Articles.asp?ID=6408)
Keywords: cefotaxime; gentamicin; sulfamethoxazole; hepatic; real; toxicity


RIS
TY - JOUR
T1 - Experimental Researches on the Effects of Some Antibiotics on Carrageenan-induced Rat Paw Inflamation
A1 - Dmour, Rashad
A2 - Tartau, Liliana Mititelu
A3 - Sindilar, Allia
A4 - Pasca, Sorin Aurelian
A5 - Nedelcu, Alin Horatiu
A6 - Crauciuc, Dragos Valentin
A7 - Drochioi, Cristian Ilie
A8 - Haliga, Raluca Ecaterina
A9 - Hilitanu, Loredana
A10 - Pinzariu, Alin Constantin
A11 - Cobzaru, Roxana Gabriela
A12 - Lupusoru, Catalina Elena
A13 - Lupusoru, Raoul Vasile
JF - Revista de Chimie
JO - Rev. Chim.
PB - Revista de Chimie SRL
SN - 2668-8212
Y1 - 2018
VL - 69
IS - 7
SP - 1744
EP - 1748
UR - https://doi.org/10.37358/RC.18.7.6408
KW - cefotaxime
KW - gentamicin
KW - sulfamethoxazole
KW - hepatic
KW - real
KW - toxicity
ER -


BibTex
@article{RevCh2018P1744,
author = {Dmour Rashad and Tartau Liliana Mititelu and Sindilar Allia and Pasca Sorin Aurelian and Nedelcu Alin Horatiu and Crauciuc Dragos Valentin and Drochioi Cristian Ilie and Haliga Raluca Ecaterina and Hilitanu Loredana and Pinzariu Alin Constantin and Cobzaru Roxana Gabriela and Lupusoru Catalina Elena and Lupusoru Raoul Vasile},
title = {Experimental Researches on the Effects of Some Antibiotics on Carrageenan-induced Rat Paw Inflamation},
journal = {Revista de Chimie},
volume = {69},
number = {7},
pages = {1744-1748},
year = {2018},
issn = {2668-8212},
doi = {https://doi.org/10.37358/RC.18.7.6408},
url = {https://revistadechimie.ro/Articles.asp?ID=6408}
}
 
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