Biopolymers with Medical Applications Optimized method for obtaining chitosan-based delivery systems<br>

Confederat, Luminita; Motrescu, Iuliana; Constantin, Sandra; Lupascu, Florentina; Profire, Lenuta

Luminita Confederat, Iuliana Motrescu, Sandra Constantin, Florentina Lupascu, Lenuta Profire

Biopolymers with Medical Applications Optimized method for obtaining chitosan-based delivery systems

Abstract:

The aim of this study was to optimize the method used for obtaining microparticles based on chitosan - a biocompatible, biodegradable, and nontoxic polymer, and to characterize the developed systems. Chitosan microparticles, as drug delivery systems were obtained by inotropic gelation method using pentasodiumtripolyphosphate (TPP) as cross-linking agent. Chitosan with low molecular weight (CSLMW) in concentration which ranged between 0.5 and 5 %, was used while the concentration of cross-linking agent ranged between 1 and 5%. The characterization of the microparticles in terms of shape, uniformity and adhesion was performed in solution and dried state. The size of the microparticles and the degree of swelling were also determined. The structure and the morphology of the developed polymeric systems were analyzed by Fourier transform infrared spectroscopy (FTIR) and scanning electron microscopy (SEM).The average diameter of the chitosan microparticles was around 522 µm. The most stable microparticles were obtained using CSLMW 1% and TPP 2% or CSLMW 0.75%and TPP 1%. The micropaticles were spherical, uniform and without flattening. Using CSLMW in concentration of 0.5 % poorly cross-linked and crushed microparticles have been obtained at all TPP concentrations. By optimization of the method, stable chitosan-based micropaticles were obtained which will be used to develop controlled release systems for drug delivery.

Keywords:
biopolymers; chitosan; microparticles

Issue: 2018, Volume 69, Issue 7

Pages: 1756-1759

Publication date: 2018/8/15

https://doi.org/10.37358/RC.18.7.6411

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This article is published under the Creative Commons Attribution 4.0 International License

Citation Styles

Cite this article as:
CONFEDERAT, L., MOTRESCU, I., CONSTANTIN, S., LUPASCU, F., PROFIRE, L., Biopolymers with Medical Applications Optimized method for obtaining chitosan-based delivery systems
, Rev. Chim., 69(7), 2018, 1756-1759.

Vancouver
Confederat L, Motrescu I, Constantin S, Lupascu F, Profire L. Biopolymers with Medical Applications Optimized method for obtaining chitosan-based delivery systems
. Rev. Chim.[internet]. 2018 Jul;69(7):1756-1759. Available from: https://doi.org/10.37358/RC.18.7.6411

APA 6th edition
Confederat, L., Motrescu, I., Constantin, S., Lupascu, F. & Profire, L. (2018). Biopolymers with Medical Applications Optimized method for obtaining chitosan-based delivery systems
. Revista de Chimie, 69(7), 1756-1759. https://doi.org/10.37358/RC.18.7.6411

Harvard
Confederat, L., Motrescu, I., Constantin, S., Lupascu, F., Profire, L. (2018). 'Biopolymers with Medical Applications Optimized method for obtaining chitosan-based delivery systems
', Revista de Chimie, 69(7), pp. 1756-1759. https://doi.org/10.37358/RC.18.7.6411

IEEE
L. Confederat, I. Motrescu, S. Constantin, F. Lupascu, L. Profire, "Biopolymers with Medical Applications Optimized method for obtaining chitosan-based delivery systems
". Revista de Chimie, vol. 69, no. 7, pp. 1756-1759, 2018. [online]. https://doi.org/10.37358/RC.18.7.6411

Text
Luminita Confederat, Iuliana Motrescu, Sandra Constantin, Florentina Lupascu, Lenuta Profire,
Biopolymers with Medical Applications Optimized method for obtaining chitosan-based delivery systems
,
Revista de Chimie,
Volume 69, Issue 7,
2018,
Pages 1756-1759,
ISSN 2668-8212,
https://doi.org/10.37358/RC.18.7.6411.
(https://revistadechimie.ro/Articles.asp?ID=6411)
Keywords: biopolymers; chitosan; microparticles

RIS
TY - JOUR
T1 - Biopolymers with Medical Applications Optimized method for obtaining chitosan-based delivery systems

A1 - Confederat, Luminita
A2 - Motrescu, Iuliana
A3 - Constantin, Sandra
A4 - Lupascu, Florentina
A5 - Profire, Lenuta
JF - Revista de Chimie
JO - Rev. Chim.
PB - Revista de Chimie SRL
SN - 2668-8212
Y1 - 2018
VL - 69
IS - 7
SP - 1756
EP - 1759
UR - https://doi.org/10.37358/RC.18.7.6411
KW - biopolymers; chitosan; microparticles
ER -

BibTex
@article{RevCh2018P1756,
author = {Confederat Luminita and Motrescu Iuliana and Constantin Sandra and Lupascu Florentina and Profire Lenuta},
title = {Biopolymers with Medical Applications Optimized method for obtaining chitosan-based delivery systems
},
journal = {Revista de Chimie},
volume = {69},
number = {7},
pages = {1756-1759},
year = {2018},
issn = {2668-8212},
doi = {https://doi.org/10.37358/RC.18.7.6411},
url = {https://revistadechimie.ro/Articles.asp?ID=6411}
}

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