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https://doi.org/10.37358/Rev.Chim.1949

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Revista de Chimie (Rev. Chim.), Year 2018, Volume 69, Issue 7, 1802-1807

https://doi.org/10.37358/RC.18.7.6420

Ioana Aurita Albu Stan, Cecilia Petrovan, Diana Cerghizan, Daniel Emil Albu, Adriana Elena Craciun, Constantin Copotoiu

Chemical Features of Bisphosphonates and Histopathological Outcomes in Rat Jaw Treated with Zoledronic Acid Combined with Dexamethasone

Abstract:

Bisphosphonate related osteonecrosis of the jaws (BRONJ) is a pathological entity described for the first time in 2003; three criteria are mandatory: no radiotion therapy,exposed bone in oral cavities for at least eight weeks with no signs of healing, bisphosphonate therapy in present or in the past,in patients with bisphosphonate therapy in present or in the past. Bisphosphonates (BPs) are stable analogues of natural inorganic pyrophosphate, which inhibit bone resorption. In literature, most patients diagnosed with BRONJ were suffering from multiple myeloma and they had a treatment with nitrogen containing BPs and steroids such as dexamethasone intravenously. With this study we have aimed to achieve a rat model of BRONJ and to evaluate histopathological findings how concurrent use of BPs and steroids can affect emergence of BRONJ in this study.
Keywords:
bisphosphonates; dexamethasone; osteonecrosis; jaw; zoledronic acid

Issue: 2018, Volume 69, Issue 7
Pages: 1802-1807
Publication date: 2018/8/15
https://doi.org/10.37358/RC.18.7.6420
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Creative Commons License
This article is published under the Creative Commons Attribution 4.0 International License
Citation Styles
Cite this article as:
STAN, I.A.A., PETROVAN, C., CERGHIZAN, D., ALBU, D.E., CRACIUN, A.E., COPOTOIU, C., Chemical Features of Bisphosphonates and Histopathological Outcomes in Rat Jaw Treated with Zoledronic Acid Combined with Dexamethasone, Rev. Chim., 69(7), 2018, 1802-1807.

Vancouver
Stan IAA, Petrovan C, Cerghizan D, Albu DE, Craciun AE, Copotoiu C. Chemical Features of Bisphosphonates and Histopathological Outcomes in Rat Jaw Treated with Zoledronic Acid Combined with Dexamethasone. Rev. Chim.[internet]. 2018 Jul;69(7):1802-1807. Available from: https://doi.org/10.37358/RC.18.7.6420


APA 6th edition
Stan, I.A.A., Petrovan, C., Cerghizan, D., Albu, D.E., Craciun, A.E. & Copotoiu, C. (2018). Chemical Features of Bisphosphonates and Histopathological Outcomes in Rat Jaw Treated with Zoledronic Acid Combined with Dexamethasone. Revista de Chimie, 69(7), 1802-1807. https://doi.org/10.37358/RC.18.7.6420


Harvard
Stan, I.A.A., Petrovan, C., Cerghizan, D., Albu, D.E., Craciun, A.E., Copotoiu, C. (2018). 'Chemical Features of Bisphosphonates and Histopathological Outcomes in Rat Jaw Treated with Zoledronic Acid Combined with Dexamethasone', Revista de Chimie, 69(7), pp. 1802-1807. https://doi.org/10.37358/RC.18.7.6420


IEEE
I.A.A. Stan, C. Petrovan, D. Cerghizan, D.E. Albu, A.E. Craciun, C. Copotoiu, "Chemical Features of Bisphosphonates and Histopathological Outcomes in Rat Jaw Treated with Zoledronic Acid Combined with Dexamethasone". Revista de Chimie, vol. 69, no. 7, pp. 1802-1807, 2018. [online]. https://doi.org/10.37358/RC.18.7.6420


Text
Ioana Aurita Albu Stan, Cecilia Petrovan, Diana Cerghizan, Daniel Emil Albu, Adriana Elena Craciun, Constantin Copotoiu,
Chemical Features of Bisphosphonates and Histopathological Outcomes in Rat Jaw Treated with Zoledronic Acid Combined with Dexamethasone,
Revista de Chimie,
Volume 69, Issue 7,
2018,
Pages 1802-1807,
ISSN 2668-8212,
https://doi.org/10.37358/RC.18.7.6420.
(https://revistadechimie.ro/Articles.asp?ID=6420)
Keywords: bisphosphonates; dexamethasone; osteonecrosis; jaw; zoledronic acid


RIS
TY - JOUR
T1 - Chemical Features of Bisphosphonates and Histopathological Outcomes in Rat Jaw Treated with Zoledronic Acid Combined with Dexamethasone
A1 - Stan, Ioana Aurita Albu
A2 - Petrovan, Cecilia
A3 - Cerghizan, Diana
A4 - Albu, Daniel Emil
A5 - Craciun, Adriana Elena
A6 - Copotoiu, Constantin
JF - Revista de Chimie
JO - Rev. Chim.
PB - Revista de Chimie SRL
SN - 2668-8212
Y1 - 2018
VL - 69
IS - 7
SP - 1802
EP - 1807
UR - https://doi.org/10.37358/RC.18.7.6420
KW - bisphosphonates
KW - dexamethasone
KW - osteonecrosis
KW - jaw
KW - zoledronic acid
ER -


BibTex
@article{RevCh2018P1802,
author = {Stan Ioana Aurita Albu and Petrovan Cecilia and Cerghizan Diana and Albu Daniel Emil and Craciun Adriana Elena and Copotoiu Constantin},
title = {Chemical Features of Bisphosphonates and Histopathological Outcomes in Rat Jaw Treated with Zoledronic Acid Combined with Dexamethasone},
journal = {Revista de Chimie},
volume = {69},
number = {7},
pages = {1802-1807},
year = {2018},
issn = {2668-8212},
doi = {https://doi.org/10.37358/RC.18.7.6420},
url = {https://revistadechimie.ro/Articles.asp?ID=6420}
}
 
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