Biochemical Effects of Retinoid Derivatives on Mesenchymal Stem Cells In Vitro

Vasincu, Decebal; Iancu, Roxana Irina; Cazan, Ionut; Stoleriu, Gabriela; Costuleanu, Marcel

Decebal Vasincu, Roxana Irina Iancu, Ionut Cazan, Gabriela Stoleriu, Marcel Costuleanu

Biochemical Effects of Retinoid Derivatives on Mesenchymal Stem Cells In Vitro

Abstract:

The studies we performed targeted the effects of all-trans retinol (vitamin A) and some retinoid derivatives (including tretinoin or all-trans retinoic acid, retinyl propionate, 9-cis retinoic acid, 13-cis retinoic acid), as well as of tazarotenic acid on apoptosis of rat mesenchymal stem cells, cultured after isolation. Tazarotenic acid is considered to be relatively selective and a potent agonist for RARb and RARg and less for RARa. The same time, tazarotenic acid is not binding to RXRs (retinoid X receptors). The relevant analysis of our experimental results demonstrated that 13-cis retinoic acid was the most potent inducer of apoptosis of cultured mesenchymal stem cells of rat origin when compared to other retinoid derivatives, as follows: 13-cis retinoic acid ] 9-cis retinoic acid ] tazarotenic acid ] all-trans retinoic acid ] retinyl propionate ] retinol (or vitamin A). Very interesting and unexpected were the apoptotic effects of 1 µM tazarotenic acid for 24 hours in our experiments, very close to those induced by all-trans retinoic acid (tretinoin). The apoptosis induced by 13-cis retinoic acid, a principal activator of RARb and RARg, and that induced by 9-cis retinoic acid, a major activator of RXRs, suggests different pathways activated by these retinoid derivatives.

Keywords:
mesenchymal stem cell; rat; apoptosis; 13-cis retinoic acid; 9-cis retinoic acid

Issue: 2018, Volume 69, Issue 7

Pages: 1817-1820

Publication date: 2018/8/15

https://doi.org/10.37358/RC.18.7.6423

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This article is published under the Creative Commons Attribution 4.0 International License

Citation Styles

Cite this article as:
VASINCU, D., IANCU, R.I., CAZAN, I., STOLERIU, G., COSTULEANU, M., Biochemical Effects of Retinoid Derivatives on Mesenchymal Stem Cells In Vitro, Rev. Chim., 69(7), 2018, 1817-1820.

Vancouver
Vasincu D, Iancu RI, Cazan I, Stoleriu G, Costuleanu M. Biochemical Effects of Retinoid Derivatives on Mesenchymal Stem Cells In Vitro. Rev. Chim.[internet]. 2018 Jul;69(7):1817-1820. Available from: https://doi.org/10.37358/RC.18.7.6423

APA 6th edition
Vasincu, D., Iancu, R.I., Cazan, I., Stoleriu, G. & Costuleanu, M. (2018). Biochemical Effects of Retinoid Derivatives on Mesenchymal Stem Cells In Vitro. Revista de Chimie, 69(7), 1817-1820. https://doi.org/10.37358/RC.18.7.6423

Harvard
Vasincu, D., Iancu, R.I., Cazan, I., Stoleriu, G., Costuleanu, M. (2018). 'Biochemical Effects of Retinoid Derivatives on Mesenchymal Stem Cells In Vitro', Revista de Chimie, 69(7), pp. 1817-1820. https://doi.org/10.37358/RC.18.7.6423

IEEE
D. Vasincu, R.I. Iancu, I. Cazan, G. Stoleriu, M. Costuleanu, "Biochemical Effects of Retinoid Derivatives on Mesenchymal Stem Cells In Vitro". Revista de Chimie, vol. 69, no. 7, pp. 1817-1820, 2018. [online]. https://doi.org/10.37358/RC.18.7.6423

Text
Decebal Vasincu, Roxana Irina Iancu, Ionut Cazan, Gabriela Stoleriu, Marcel Costuleanu,
Biochemical Effects of Retinoid Derivatives on Mesenchymal Stem Cells In Vitro,
Revista de Chimie,
Volume 69, Issue 7,
2018,
Pages 1817-1820,
ISSN 2668-8212,
https://doi.org/10.37358/RC.18.7.6423.
(https://revistadechimie.ro/Articles.asp?ID=6423)
Keywords: mesenchymal stem cell; rat; apoptosis; 13-cis retinoic acid; 9-cis retinoic acid

RIS
TY - JOUR
T1 - Biochemical Effects of Retinoid Derivatives on Mesenchymal Stem Cells In Vitro
A1 - Vasincu, Decebal
A2 - Iancu, Roxana Irina
A3 - Cazan, Ionut
A4 - Stoleriu, Gabriela
A5 - Costuleanu, Marcel
JF - Revista de Chimie
JO - Rev. Chim.
PB - Revista de Chimie SRL
SN - 2668-8212
Y1 - 2018
VL - 69
IS - 7
SP - 1817
EP - 1820
UR - https://doi.org/10.37358/RC.18.7.6423
KW - mesenchymal stem cell
KW - rat
KW - apoptosis
KW - 13-cis retinoic acid
KW - 9-cis retinoic acid
ER -

BibTex
@article{RevCh2018P1817,
author = {Vasincu Decebal and Iancu Roxana Irina and Cazan Ionut and Stoleriu Gabriela and Costuleanu Marcel},
title = {Biochemical Effects of Retinoid Derivatives on Mesenchymal Stem Cells In Vitro},
journal = {Revista de Chimie},
volume = {69},
number = {7},
pages = {1817-1820},
year = {2018},
issn = {2668-8212},
doi = {https://doi.org/10.37358/RC.18.7.6423},
url = {https://revistadechimie.ro/Articles.asp?ID=6423}
}

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