The Evaluation of the Role of the Cytokines TNF- alfa and IL 6 in the Production of Hypoalbuminemia in Patients Undergoing Major Surgical Interventions

Nicolescu, Cristian; Pop, Alaxendru; Mihu, Alin; Pilat, Luminita; Bedreag, Ovidiu; Nicolescu, Laura

Cristian Nicolescu, Alaxendru Pop, Alin Mihu, Luminita Pilat, Ovidiu Bedreag, Laura Nicolescu

The Evaluation of the Role of the Cytokines TNF- alfa and IL 6 in the Production of Hypoalbuminemia in Patients Undergoing Major Surgical Interventions

Abstract:

This article presents an observational randomized prospective study done on 65 patients, who underwent major surgical interventions in the field of orthopedic surgery-total hip replacement or general surgery - total colectomy. The level of albuminemia in these cases were determined before the surgical intervention, after 6 hours of the intervention and after 24 h of the intervention. The measurements of the plasmatic concentration of the pro-inflammatory cytokines Tumor Necrosis factor -alpha (TNF-alpha) and interleukin 6 (IL6) were simultaneously done with the determination of the plasmatic levels of albumin. Values of hemoglobin and hematocrit were determined 24 h after the surgical procedure in order to exclude hemodilution, which could lead to a possible drop in the levels of plasmatic albumin. After the collection of the data, the statistical work was done and it consisted of descriptive statistics, correlation and comparison tests as well as statistical validation tests. Obtained results indicate that IL-6 plays a major role comparatively with that of TNF-alfa, regarding the decrease of the plasmatic level of albumin, and due to this, the primordial cause for hypoalbuminemia is an acute hepatic phase reaction. Supplemental permeability of the capillary wall under the action of TNF alpha has a secondary role, but could lead to a faster decrease in plasmatic albumin in the first hours after the surgical procedure.

Keywords:
hypoalbuminemia; TNF-alpha; plasmatic protein; hemoglobin; hematocrit; albuminemia; IL 6

Issue: 2018, Volume 69, Issue 7

Pages: 1830-1837

Publication date: 2018/8/15

https://doi.org/10.37358/RC.18.7.6426

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Citation Styles

Cite this article as:
NICOLESCU, C., POP, A., MIHU, A., PILAT, L., BEDREAG, O., NICOLESCU, L., The Evaluation of the Role of the Cytokines TNF- alfa and IL 6 in the Production of Hypoalbuminemia in Patients Undergoing Major Surgical Interventions, Rev. Chim., 69(7), 2018, 1830-1837.

Vancouver
Nicolescu C, Pop A, Mihu A, Pilat L, Bedreag O, Nicolescu L. The Evaluation of the Role of the Cytokines TNF- alfa and IL 6 in the Production of Hypoalbuminemia in Patients Undergoing Major Surgical Interventions. Rev. Chim.[internet]. 2018 Jul;69(7):1830-1837. Available from: https://doi.org/10.37358/RC.18.7.6426

APA 6th edition
Nicolescu, C., Pop, A., Mihu, A., Pilat, L., Bedreag, O. & Nicolescu, L. (2018). The Evaluation of the Role of the Cytokines TNF- alfa and IL 6 in the Production of Hypoalbuminemia in Patients Undergoing Major Surgical Interventions. Revista de Chimie, 69(7), 1830-1837. https://doi.org/10.37358/RC.18.7.6426

Harvard
Nicolescu, C., Pop, A., Mihu, A., Pilat, L., Bedreag, O., Nicolescu, L. (2018). 'The Evaluation of the Role of the Cytokines TNF- alfa and IL 6 in the Production of Hypoalbuminemia in Patients Undergoing Major Surgical Interventions', Revista de Chimie, 69(7), pp. 1830-1837. https://doi.org/10.37358/RC.18.7.6426

IEEE
C. Nicolescu, A. Pop, A. Mihu, L. Pilat, O. Bedreag, L. Nicolescu, "The Evaluation of the Role of the Cytokines TNF- alfa and IL 6 in the Production of Hypoalbuminemia in Patients Undergoing Major Surgical Interventions". Revista de Chimie, vol. 69, no. 7, pp. 1830-1837, 2018. [online]. https://doi.org/10.37358/RC.18.7.6426

Text
Cristian Nicolescu, Alaxendru Pop, Alin Mihu, Luminita Pilat, Ovidiu Bedreag, Laura Nicolescu,
The Evaluation of the Role of the Cytokines TNF- alfa and IL 6 in the Production of Hypoalbuminemia in Patients Undergoing Major Surgical Interventions,
Revista de Chimie,
Volume 69, Issue 7,
2018,
Pages 1830-1837,
ISSN 2668-8212,
https://doi.org/10.37358/RC.18.7.6426.
(https://revistadechimie.ro/Articles.asp?ID=6426)
Keywords: hypoalbuminemia; TNF-alpha; plasmatic protein; hemoglobin; hematocrit; albuminemia; IL 6

RIS
TY - JOUR
T1 - The Evaluation of the Role of the Cytokines TNF- alfa and IL 6 in the Production of Hypoalbuminemia in Patients Undergoing Major Surgical Interventions
A1 - Nicolescu, Cristian
A2 - Pop, Alaxendru
A3 - Mihu, Alin
A4 - Pilat, Luminita
A5 - Bedreag, Ovidiu
A6 - Nicolescu, Laura
JF - Revista de Chimie
JO - Rev. Chim.
PB - Revista de Chimie SRL
SN - 2668-8212
Y1 - 2018
VL - 69
IS - 7
SP - 1830
EP - 1837
UR - https://doi.org/10.37358/RC.18.7.6426
KW - hypoalbuminemia
KW - TNF-alpha
KW - plasmatic protein
KW - hemoglobin
KW - hematocrit
KW - albuminemia
KW - IL 6
ER -

BibTex
@article{RevCh2018P1830,
author = {Nicolescu Cristian and Pop Alaxendru and Mihu Alin and Pilat Luminita and Bedreag Ovidiu and Nicolescu Laura},
title = {The Evaluation of the Role of the Cytokines TNF- alfa and IL 6 in the Production of Hypoalbuminemia in Patients Undergoing Major Surgical Interventions},
journal = {Revista de Chimie},
volume = {69},
number = {7},
pages = {1830-1837},
year = {2018},
issn = {2668-8212},
doi = {https://doi.org/10.37358/RC.18.7.6426},
url = {https://revistadechimie.ro/Articles.asp?ID=6426}
}

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